Clinical trials: Clinical Pain
Neuropathy, Paraneoplastic
MC-5A for Chemotherapy Induced Peripheral Neuropathy
Painful chemotherapy induced peripheral neuropathy (CIPN) is a common complication of cancer therapy with few treatment options.
- Trial name
- NCT01261780
- Testing
- MC-5A
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Cancer, Pain
An Efficacy and Safety Study of Hydromorphone Hydrochloride (HCl) Oral Osmotic System (OROS) in the Reduction of Breakthrough Pain Medication Frequency in Participants With Cancer
The purpose of this study is to evaluate the clinical efficacy of hydromorphone hydrochloride (HCl) Oral Osmotic System (OROS) by assessing the extent of reduction of medication frequency for the management of breakthrough pain…
- Trial name
- NCT01006356
- Testing
- Hydromorphone HCl OROS
- Volunteers
- 141 people
- Sponsor
- Janssen Korea, Ltd., Korea
Aging, Pain
RHA® 4 With New Anesthetic - Nasolabial Folds
This is a randomized, controlled, double-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA® 4 with New Anesthetic Agent is non-inferior to RHA® 4 (with lidocaine) in terms of…
- Trial name
- NCT04087395
- Testing
- RHA®4 with new anesthetic agent, RHA®4-Lidocaine
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Carpal Tunnel Syndrome
Comparison of Two Techniques for the Treatment of Carpal Tunnel Syndrome
The main objective of this study is to compare the complete section of the transverse carpal ligament with another median nerve release technique and to determine if the incidence of post-surgical pillar pain is lower for either…
- Trial name
- STCCOT (NCT05468814)
- Testing
- Z-plasty, Conventional
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitario Reina Sofia de Cordoba
Interstitial Cystitis, Bladder Pain Syndrome
Clinical Trial Comparing Two Bladder Instillations for IC/BPS
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a condition that results in long-term bladder and pelvic pain. IC/BPS affects women more often than men. How the disorder develops is not completely known.
- Trial name
- NCT03463915
- Testing
- Bladder instillation WITH triamcinolone acetonide, Bladder instillation WITHOUT triamcinolone acetonide
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Olivia Cardenas-Trowers, M.D.
Atrophic Vaginitis
A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis
The purpose of this study is to determine the therapeutic equivalence of Mylan's estradiol vaginal cream to Estrace® cream and superiority of both products to placebo.
- Trial name
- NCT02195986
- Testing
- Estradiol Vaginal Cream, 0.01%, Estrace® 0.01% cream
- Where
- 21 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Inflammation, Cancer
NSAID Effects on Clinical and Imaging Breast Biomarkers
This study has two purposes. One is to determine if daily sulindac decreases breast density; a risk factor for breast cancer development.
- Conditions
- Inflammation, Cancer, Pain, Hypertension
- Trial name
- NCT01761877
- Testing
- Sulindac
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Stony Brook University
Low Back Pain
Translation of Robotic Apparel for Alleviating Low Back Pain
This is a NIAMS-sponsored clinical trial being conducted through the NIH Helping to End Addition Long-term (HEAL) Initiative's Back Pain Consortium (BACPAC) Research Program.
- Trial name
- NCT05736393
- Testing
- Back Exosuit
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Boston University Charles River Campus
Chronic Coronary Syndrome, Hypertension
Benidipine in Hypertensive and/or Chronic Coronary Syndrome Patients
Evaluation of the clinical outcomes of Benidipine initiated by physician's preference in patients with hypertension and/or angina pectoris (chronic coronary syndrome) presenting to cardiology outpatient clinics in Türkiye.
- Conditions
- Chronic Coronary Syndrome, Hypertension, Angina Pectoris
- Trial name
- BenidipineTR (NCT06808321)
- Testing
- Benidipine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 1,659 people
- Sponsor
- The Society of Prevention and Awareness of Cardiovascular Diseases
Metastatic Prostate Cancer, Pain
Non-Randomized Trial Assessing Pain Efficacy With Radium-223 in Symptomatic Metastatic Castration-Resistant Prostate Cancer
The purpose of this study is to find out if Radium-223 is effective in reducing cancer pain within 12 weeks of treatment. In order to see if Radium-223 is effective, the patient's level of pain will be followed throughout the…
- Trial name
- NCT02278055
- Testing
- Radium-223
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pain
Chronic Pain OneSheet Clinical Trial
The purpose of the study is to determine whether and how having access to the Chronic Pain OneSheet clinical decision support tool in Epic affects the ordering, prescribing, goal-setting, risk monitoring, and outcome measuring…
- Trial name
- NCT04295135
- Testing
- Chronic Pain OneSheet
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Indiana University
Headache
The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus Ketamine
Investigators are comparing Ketamine to prochlorperazinecompazine for benign headaches in the ED. Subjects will be randomized into 1 of 2 groups.
- Trial name
- Check (NCT02735343)
- Testing
- Compazine, Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mike O'Callaghan Military Hospital
Kidney Cancer, Prostate Cancer
Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic Surgery
Controlling pain is fundamental during and after surgical procedures. This study examines pain associated with robotic assisted surgery on prostate cancer or a kidney mass.
- Trial name
- NCT03824808
- Testing
- Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution, 0.9% Sodium Chloride Injection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Missouri-Columbia
Posttraumatic Stress Disorder, Sexual Assault
RCT for Innovating Stress-related eHealth
The Randomized Control Trial for Innovating Stress-related eHealth (RISE) Study tests the hypotheses that a highly promising digital therapeutic (RISE Guide) targeting anxiety sensitivity (AS) will be acceptable to women sexual…
- Conditions
- Posttraumatic Stress Disorder, Sexual Assault, Pain
- Trial name
- RISE (NCT05305235)
- Testing
- RISE Guide, Relaxation Control
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Musculoskeletal Complications, Pain
Prevention of Pegfilgrastim-Induced Bone Pain (PIBP)
RATIONALE: Naproxen may help prevent or lessen bone pain caused by pegfilgrastim. It is not yet known whether naproxen is more effective than a placebo in preventing bone pain caused by pegfilgrastim in patients with…
- Conditions
- Musculoskeletal Complications, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00602420
- Testing
- naproxen
- Where
- 16 sites in United States
- Volunteers
- 510 people
- Sponsor
- Gary Morrow
Pain, Osteo Arthritis Knee
Clinical Trial to Evaluate the Efficacy and Safety of LEVI-04 in Patients With Osteoarthritis of the Knee
This is a phase 2, randomized, double-blind, placebo-controlled trial of multiple doses and multiple administrations of LEVI-04 for the treatment of pain due to osteoarthritis of the knee.
- Conditions
- Pain, Osteo Arthritis Knee, Knee Osteoarthritis, Arthritis
- Trial name
- NCT05618782
- Testing
- LEVI-04
- Where
- 13 sites in Czechia, Denmark and 3 more
- Volunteers
- 518 people
- Sponsor
- Levicept
Myofascial Dysfunction
Quantifying Myofascial Dysfunction in Post-Stroke Pain
The purpose of this study is to quantify the extent of GlycosAminoGlycan/Hyaluronic Acid (GAG/HA) accumulation using T1rho (T1ρ) MRI in the paretic versus non-paretic shoulder rotator muscles, and correlate the T1ρ Magnetic…
- Trial name
- Myofascial (NCT05762679)
- Testing
- Imaging
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Johns Hopkins University
Total Shoulder Arthroplasty
Exparel for Total Shoulder Arthroplasty
The primary objective of this study is to determine if Exparel leads to better pain scores at 24, 48 and 72 hours after Total Shoulder Arthroplasty (TSA) compared to a pain pump.
- Trial name
- NCT04364867
- Testing
- Exparel, Pain Pump
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Norton Healthcare
Headache
Intravenous Fluids in Benign Headaches Trial
Migraine headache has a 1-year period prevalence in the US of 11.7% and accounts for approximately 1.2 million migraine visits to US emergency departments per year .
- Trial name
- I-FiBH (NCT03185130)
- Testing
- Normal Saline 5mL, Normal Saline 20mL/kg, Prochlorperazine 0.15 mg/kg up to 10 mg IV
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University Medical Center of Southern Nevada
Functional Bowel Disorder
Efficacy and Safety of Mebeverine + Simethicone in Patients With Functional Bowel Disorders
The parallel three-group study of efficacy and safety was planned to investigate the reduction in abdominal pain and bloating during treatment with the fixed-dose combination of Mebeverine + Simethicone versus Duspatalin® and…
- Trial name
- NCT05175131
- Testing
- Mebeverine+Simethicone, Mebeverine, Simethicone
- Where
- Russia
- Volunteers
- 465 people
- Sponsor
- Abbott