Clinical trials: Clinical Research
Dermatitis, Atopic, Eczema
Skin Effects of a Topical Amino Acid Moisturizing Cream and Desonide in Atopic Dermatitis
The purpose of this study is to compare the effects of an amino acid moisturizing cream and desonide cream in reducing skin symptoms associated with AD/eczema in subjects with mild to moderate atopic dermatitis/eczema.
- Trial name
- NCT02286700
- Testing
- Desonide Cream, Amino Acid Moisturizing Cream
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- NeoStrata Company, Inc.
Arthritis, Rheumatoid
A Study Of The Taste Of Different Oral Liquid Preparations Of CP-690,550 In Trained Adult Product Testers
This study will test the palatability of several different CP-690,550 oral preparations in trained product tester healthy volunteers.
- Trial name
- NCT01023100
- Testing
- CP 690,550 oral solutions
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Pfizer
Advanced Solid Tumors
First in Human Trial of TAS266 in Patients With Advanced Solid Tumors
This study will assess safety, tolerability, maximum tolerated dose or recommended dose for expansion of TAS266 administered by IV infusion to patients with advanced solid tumors.
- Trial name
- NCT01529307
- Testing
- TAS266
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Novartis Pharmaceuticals
Melanoma
A Study to Assess APO866 for the Treatment of Advanced Melanoma
This phase II study is designed to determine the efficacy and safety of APO866 for the treatment of patients with advanced cutaneous melanoma.
- Trial name
- NCT00432107
- Testing
- APO866
- Where
- 6 sites in Austria, France and 2 more
- Volunteers
- 25 people
- Sponsor
- Valerio Therapeutics
Celiac Disease
Study to Evaluate the Efficacy and Safety of Larazotide Acetate for the Relief of CeD Symptoms
To assess the efficacy and safety of larazotide acetate versus placebo for the relief of persistent symptoms in adult celiac disease patients.
- Trial name
- NCT03569007
- Testing
- Larazotide
- Where
- 160 sites in United States
- Volunteers
- 307 people
- Sponsor
- 9 Meters Biopharma, Inc.
Advanced Malignant Tumors
A Clinical Study to Evaluate the Tolerability and Pharmacokinetics of TQB3617 Capsule in Patients With Advanced Malignant Tumors
TQB3617 is a bromodomain and extra-terminal (BET) inhibitor that can competitively bind to bromodomains (BRDs) with Acetylated lysine(Kac) and block or partially block the role of KAc in subsequent gene transcription and…
- Trial name
- NCT05110807
- Testing
- TQB3617
- Where
- 2 sites in China
- Volunteers
- 38 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Advanced Cancer
A Phase 1 Study of LY2874455 in Participants With Advanced Cancer
The study is to determine the recommended Phase 2 regimen of study drug that may be safely administered to participants with advanced and or metastatic cancer.
- Trial name
- NCT01212107
- Testing
- FGF Receptor, Phosphate Binders
- Where
- 3 sites in Australia, South Korea
- Volunteers
- 94 people
- Sponsor
- Eli Lilly and Company
Primary Breast Augmentation, Primary Breast Reconstruction
Memory Gel and Shape Combined Cohort
The purpose of this study is to collect additional post-approval clinical data on the long-term performance of MemoryShape and MemoryGel Breast Implants, as indicated for primary or revisional breast augmentation and primary or…
- Conditions
- Primary Breast Augmentation, Primary Breast Reconstruction, Revision Breast Augmentation, Revision Breast Reconstruction
- Trial name
- Glow (NCT02919592)
- Testing
- MemoryShape® Breast Implants, MemoryGel® Breast Implants, Other Aesthetic Surgery
- Where
- 78 sites in United States
- Volunteers
- 3,603 people
- Sponsor
- Mentor Worldwide, LLC
Jaw, Edentulous
Multicenter Study to Evaluate the Clinical Outcome of the OmniTaper EV Implant in Single Tooth Restorations
This clinical study, funded by the company Dentsply Sirona, is being carried out to see if the newly developed tooth implant "OmniTaper EV" is safe, effective and functions as intended when replacing a lost or removed tooth.
- Trial name
- NCT05355792
- Testing
- OmniTaper EV implants
- Where
- 6 sites in Germany, Switzerland and 1 more
- Volunteers
- 139 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Heart Failure With Reduced Ejection Fraction
RECOVER-HF Pilot Study of SDS in Heart Failure
The RECOVER HF pilot is a feasibility study for evaluating a randomized, doubled-blinded study design to determine the benefits and risks of chronically delivering Synchronized Diaphragmatic Stimulation (SDS) in Heart Failure…
- Trial name
- NCT05592392
- Testing
- Synchronized Diaphragmatic Stimulation
- Where
- 2 sites in Georgia, Uzbekistan
- Volunteers
- 35 people
- Sponsor
- VisCardia Inc.
Anemia
TRANSFORM - Observational Cohort Study of Darbepoetin Alfa Use in European Union (EU) Hemodialysis Patients Switched From PEG Epoetin Beta
To describe the time course of hemoglobin concentration in EU hemodialysis patients switched from methoxy polyethylene glycol-epoetin beta (PEG epoetin beta; Mircera) to darbepoetin alfa (Aranesp).
- Trial name
- TRANSFORM (NCT01997892)
- Where
- 32 sites in Belgium, France and 5 more
- Volunteers
- 1,027 people
- Sponsor
- Amgen
Menstruation
In-use Study of Four Different Tampons
This study will evaluate the impact on vaginal health of four different tampons using gynecologic assessment and subjective assessment of comfort during in-use conditions
- Trial name
- NCT03478371
- Testing
- tampon D, tampon M, tampon T
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Depth of Anesthesia (DOA)
Effectiveness of the NeuroSENSE for Monitoring the Hypnotic Depth of Anesthesia
The objective of this clinical study is to investigate whether the NeuroSENSE is an adequate monitor of hypnotic depth-of-anesthesia (DOA).
- Trial name
- NCT02088671
- Testing
- Propofol induction followed by randomized doses of desflurane, Recording of EEG using NeuroSENSE, Data collection
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- NeuroWave Systems Inc.
Colorectal Cancer
A Study of Avastin (Bevacizumab) and Oxaliplatin Plus Xeloda (Capecitabine) in Patients With Advanced Colorectal Cancer.
This study will assess the efficacy and safety of treatment with the combination Avastin (bevacizumab) 5mg/kg iv every 2 weeks, Xeloda (capecitabine) 1000 mg po b.i.d.
- Trial name
- NCT01159171
- Testing
- bevacizumab [Avastin], capecitabine [Xeloda], oxaliplatin
- Where
- 6 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Gaucher Disease
A Study of Eliglustat Tartrate (Genz-112638) in Patients With Gaucher Disease to Evaluate Once Daily Versus Twice Daily Dosing (EDGE)
The primary objective of this study was to evaluate the efficacy and safety of once daily (QD) versus twice daily (BID) dosing of eliglustat tartrate (Genz-112638) in participants with Gaucher disease type 1 who had demonstrated…
- Trial name
- NCT01074944
- Testing
- Eliglustat tartrate
- Where
- 46 sites in United States, Australia and 15 more
- Volunteers
- 170 people
- Sponsor
- Genzyme, a Sanofi Company
Schizophrenia
A Study to Evaluate Iloperidone Long-acting Injection (LAI) for the Treatment of Schizophrenia
This is a multicenter, open-label, adaptive, repeat-dose study to evaluate the safety, tolerability, and pharmacokinetics of iloperidone long-acting injection (LAI) in patients with schizophrenia.
- Trial name
- NCT04712734
- Testing
- Iloperidone
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Vanda Pharmaceuticals
Chronic Rhinosinusitis (CRS), Exacerbations
Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis
The goal of this clinical research is to learn if Imunoglukan P4H® as an add-on therapy to the standard of care treatment according to the EPOS guidelines (intranasal corticosteroids and saline irrigation) can help to prevent CRS…
- Conditions
- Chronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic Prophylaxis
- Trial name
- EPCCOR (NCT07460934)
- Testing
- Imunoglukan P4H® capsules
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 85 people
- Sponsor
- Pleuran, s.r.o.
Diabetes Mellitus, Type 1
Smart MDI Study (CIP343)
The purpose of the study is to evaluate the effectiveness of the Smart MDI system with InPen™ and Simplera™ in comparison with Multiple Daily Injection (MDI) therapy with intermittent scanning or real-time Continuous Glucose…
- Trial name
- NCT06645834
- Testing
- Smart MDI System
- Where
- 18 sites in Belgium, Czechia and 4 more
- Volunteers
- 179 people
- Sponsor
- Medtronic MiniMed, Inc.
Uveitis
Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis
This study will provide patients who have completed the AIN457 Phase II and Phase III clinical trials in non-infectious uveitis continued access to treatment with AIN457 while collecting safety data and information on long term…
- Trial name
- SUPPORT (NCT01327664)
- Testing
- AIN457
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers (HV), Parkinson's Disease (PD)
Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease
This is a first-in-human (FIH) study of orally administered VT-5006 (also known as AX-5006) in healthy adult volunteers (HVs) and adult participants with Parkinson's disease (PD).
- Trial name
- NCT07310264
- Testing
- VT-5006
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Vertero Therapeutics
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