Clinical trials: Clinical Sepsis
Carbapenem Resistant Bacteria Infection
European Prospective Cohort Study on Enterobacteriaceae Showing Resistance to Carbapenems
Among antibiotic-resistant organisms, the Gram-negative bacteria are now the most important challenge because of the rapid worldwide spread of mechanisms conferring resistance to multiple drugs.
- Trial name
- EURECA (NCT02709408)
- Where
- 50 sites in Albania, Bulgaria and 9 more
- Volunteers
- 2,515 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sepsis
A Multicenter Clinical Study of Romiplostim N01 in the Treatment of Sepsis-related Thrombocytopenia
This study intends to randomly divide the SAT patients admitted to the ICU into the ropivacaine N01 treatment group and the recombinant human thrombopoietin control group.
- Trial name
- ITJ(QN)2510 (NCT07595133)
- Testing
- Administer Romiplostim treatment., Administer recombinant human thrombopoietin therapy
- Volunteers
- 280 people
- Sponsor
- Shanghai 10th People's Hospital
Septic Shock, Arterial Pressure
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak.
- Conditions
- Septic Shock, Arterial Pressure, Hemodynamics, Mortality
- Trial name
- SEPSISPAM (NCT01149278)
- Testing
- maintain mean arterial pressure between 80-85 mm Hg, maintain mean arterial pressure between 65-70 mm Hg
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Angers
Clinical Sepsis
Improving Morbidity During Post-Acute Care Transitions for Sepsis
The purpose of this study is to improve transitions of care for the highest risk, complex patients with suspected sepsis. Atrium Health has developed a nurse-navigator facilitated care transition strategy, called the Sepsis…
- Trial name
- IMPACTS (NCT03865602)
- Testing
- Sepsis Transition And Recovery (STAR), Usual care
- Where
- United States
- Volunteers
- 712 people
- Sponsor
- Wake Forest University Health Sciences
Sepsis
Preliminary Study on the Clinical Effect of Recombinant Human Brain Natriuretic Peptide on Sepsis Complicated With Heart Failure
The investigators intend to conduct clinical studies to determine the efficacy of rhBNP in the treatment of septic related dysfunction and kidney dysfunction
- Trial name
- NCT05111769
- Testing
- Recombinant human brain natriuretic peptide
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Sepsis
Risk Factors for Adverse Outcomes in Sepsis
This multi-phase prospective study utilized Data-Independent Acquisition proteomics on a nested subset (15 SIC vs. 15 matched sepsis) to map early molecular alterations.
- Trial name
- NCT06541600
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 567 people
- Sponsor
- Qin Zhang
Pneumonia - Bacterial, Urinary Tract Infection Bacterial
Clinical Impact of a Machine Learning Decision Support System for Empirical Antibiotic Therapy
The goal of this quasi-experimental study is to analyze if a Machine Learning Clinical Decision Support System can improve the empirical antibiotic treatment in patients with pneumonia, urinary tract infection and / or sepsis.
- Conditions
- Pneumonia - Bacterial, Urinary Tract Infection Bacterial, Bloodstream Infection
- Trial name
- NCT07762378
- Testing
- Machine Learning Decision Support System
- Volunteers
- 486 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón
Sepsis and Septic Shock
HOPE-Sepsis: Hemoadsorption Therapy for Sepsis
This is a single-center, prospective, single-arm, open-label study that will enroll 30 adult patients with sepsis at Zhongshan Hospital, Fudan University.
- Trial name
- NCT07865585
- Testing
- Hemoperfusion with CA330 Cytokine Adsorption Column
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Septic Shock, Acute Kidney Injury
Early Endotoxin Burden Reduction With oXiris in Septic Shock Patients Requiring CRRT
The goal of this clinical trial is to learn whether continuous renal replacement therapy (CRRT) using the oXiris filter can lower the amount of endotoxin in the blood of adults with septic shock who need CRRT.
- Trial name
- NCT07807410
- Testing
- oXiris Hemofilter
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Acute Kidney Injury, Sepsis
Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT
Brief Summary: Evaluating a New Phosphate-Containing Fluid for Blood Purification (CRRT) Why is this study being done? Patients in the Intensive Care Unit (ICU) often need a treatment called Continuous Renal Replacement Therapy…
- Conditions
- Acute Kidney Injury, Sepsis, Critically Ill Patients Requiring Continuous Renal Replacement Therapy
- Trial name
- PHOS-CRRT (NCT07550894)
- Testing
- Phosphate-containing Replacement Fluid, Standard Phosphate-free Replacement Fluid
- Where
- 15 sites in China
- Volunteers
- 220 people
- Sponsor
- Sun Yat-sen University
Shock, Hemorrhagic, Shock, Traumatic
Polydatin Injectable (HW6) for Shock Treatment
HW6 can prolong animal's survival time and increase the survival rate. HW6 enhances cardiac function, improves microcirculation, and increases blood pressure and pulse pressure, and improves blood perfusion of important organs…
- Conditions
- Shock, Hemorrhagic, Shock, Traumatic, Shock, Septic
- Trial name
- PIST (NCT01780129)
- Testing
- Polydatin Injectable
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Neptunus Pharmaceuticals Inc.
Sepsis, Deterioration, Clinical
Hospital-Onset Sepsis Systematic Detection and Structured Interventions
Sepsis is a life-threatening reaction to an infection. It can begin while a person is already in the hospital for some other reason. Sepsis that starts in the hospital is often recognized late, and treatment can be delayed.
- Conditions
- Sepsis, Deterioration, Clinical, Critical Illness, Early Warning Score
- Trial name
- CATCH SEPSIS (NCT07804251)
- Testing
- Algorithm-triggered sepsis alert with structured critical care team activation
- Where
- United States
- Volunteers
- 3,700 people
- Sponsor
- Patricks Lyons
Staphylococcal Sepsis
Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity Study in VLBW Neonates of BSYX-A110
The purpose of this study is to evaluate the safety (including tolerability), pharmacokinetics, pharmacodynamics and clinical activity of BSYX-A110 administered in a 3-dose regimen on Study Days 0, 7, and 14.
- Trial name
- N003 (NCT00631800)
- Testing
- Pagibaximab (formerly BSYX-A110)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Biosynexus Incorporated
Sepsis
Study of Multiple-dose Kukoamine B Mesilate in Sepsis Patients
Phase I study of multiple-dose Kukoamine B Mesilate in Sepsis Patients
- Trial name
- NCT03237728
- Testing
- 0.06mg/kg,KB, 0.12mg/kg,KB, 0.24mg/,KB
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Tianjin Chasesun Pharmaceutical Co., LTD
Septic Shock, Multiple Organ Dysfunction Syndrome
Therapeutic Plasma Exchange Adsorption Diafiltration
The purpose of this study is to evaluate the efficacy of coupled therapeutic plasma exchange adsorption diafiltration (PEAF )for treating septic shock with multiple organ dysfunction syndrome patients in ICU.
- Trial name
- PEAF (NCT03589378)
- Testing
- PEAF
- Where
- 12 sites in China
- Volunteers
- 168 people
- Sponsor
- Shenzhen Second People's Hospital
Nosocomial Infections, Sepsis
Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants
The purpose of this study is to show whether Veronate, a donor-selected staphylococcal human immune globulin intravenous (IGIV), can prevent an infection in the blood caused by staphylococcal bacteria in premature babies weighing…
- Conditions
- Nosocomial Infections, Sepsis, Staphylococcal Infections, Candidemia
- Trial name
- NCT00113191
- Testing
- Veronate
- Where
- 93 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Bristol-Myers Squibb
Inflamatory Markers
Inflammatory Markers and Clinical Score in Predicting Mortality
To evaluate the prognostic value of inflammatory markers; specifically neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and systemic inflammation immune index (SII) in…
- Trial name
- NCT07464054
- Testing
- Blood samples for aboratory test
- Volunteers
- 61 people
- Sponsor
- Assiut University
Bacteremia, Fungemia
Clinical Performance of the Accelerate ID/AST System for Positive Blood Culture
The "Evaluation of Clinical Performance of the Accelerate ID/AST System for Positive Blood Culture Identification \& Antimicrobial Susceptibility Testing" is designed to validate the clinical performance of the Accelerate ID/AST…
- Trial name
- NCT02719769
- Where
- 14 sites in United States
- Volunteers
- 4,009 people
- Sponsor
- Accelerate Diagnostics, Inc.
Sepsis, Systemic Inflammatory Response Syndrome
Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?
The aim of this project is to test the utility of The Gene Z device (as of 2018 Gene Z no longer being used), now using In-Dx and other rapid identification techniques that the investigators have developed in the lab on…
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome, Infection Mixed, Infection, Bacterial
- Trial name
- NCT01904188
- Testing
- Gene Z or other rapid diagnostic techniques developed in our lab (as of 2018 not using Gene Z - now using In-Dx along with other developed techniquesregularly)
- Where
- 2 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Michigan State University
Elbow Joint Destruction, Post-traumatic Lesions
Clinical Outcomes Study of the Nexel Total Elbow
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
- Conditions
- Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
- Trial name
- NCT02469662
- Testing
- Nexel Total Elbow
- Where
- 11 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Zimmer Biomet