Clinical trials: Clinical Sepsis
Critical Illness
Infusion Set Replacement Intervals for Critically Ill Patients
This study aimed to evaluate the efficacy of 24-hour versus 96-hour infusion set replacement to prevent central line-associated bloodstream infection (CLABSI) in critically ill adults with central venous access devices.
- Trial name
- NCT05359601
- Testing
- Infusion set replacement intervals
- Where
- China
- Volunteers
- 1,240 people
- Sponsor
- Zhongnan Hospital
Sepsis, Severe Sepsis
Vitamin D Status in Patients With Severe Sepsis
Sepsis is a clinical entity that complicates infection. Without early recognition and timely management, it can rapidly progress to severe sepsis, septic shock, and culminate in multiple organ dysfunction syndrome.
- Conditions
- Sepsis, Severe Sepsis, End Organ Damage, Multi Organ Failure
- Trial name
- ViDISS (NCT02684487)
- Testing
- vitamin D3
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Neonatal Sepsis
Neonatal Sepsis and GBS Carriage Study
In the proposed study, the investigators plan to establish the burden of early onset (EO) neonatal sepsis in the newborn population born at Maela Refugee Camp over a two year period. Aims 1.
- Trial name
- NSS (NCT00861055)
- Where
- Thailand
- Volunteers
- 849 people
- Sponsor
- University of Oxford
Kidney Failure, Chronic, Hemodialysis Complication
The Pristine Post-Market Study
This is a prospective, multi-center, single-arm study designed to assess the safety and performance of the Pristine™ Long-Term Hemodialysis Catheter.
- Conditions
- Kidney Failure, Chronic, Hemodialysis Complication, Hemodialysis Catheter Infection, Hemodialysis Access Failure
- Trial name
- NCT05228132
- Testing
- Pristine™ Long-Term Hemodialysis Catheter
- Where
- 6 sites in United States
- Volunteers
- 142 people
- Sponsor
- C. R. Bard
Malaria
Trial to Evaluate CIS43LS in Healthy Adults
Background: People get malaria when they are bitten by an infected mosquito. Malaria can be serious and sometimes deadly. Although there are medicines to treat malaria, there is no vaccine that fully prevents infection.
- Trial name
- NCT04206332
- Testing
- VRC-MALMAB0100-00-AB, Plasmodium falciparum (P. falciparum) sporozoite challenge
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sepsis
Clinical Evaluation of the Effect of Metformin in Sepsis
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is considered a condition that arises when the body's response to an infection injures its own tissues and organs.
- Trial name
- NCT05979038
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- German University in Cairo
Septic Shock, Acute Kidney Injury
MCO Membrane Efficiency in Septic Shock Patients
This is a monocentre randomized pilot study. All patients received two consecutive RRT: CVVHD with MCO filter (Ultraflux® EMiC®2) and post-Continuous Veno-Venous Hemodiafiltration (CVVHDF) with HFF(AV1000S®) in a controlled…
- Trial name
- NCT04834921
- Testing
- Ultraflux® EMiC®2
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fiorenza Ferrari
Enterobacteriaceae Infections, Bacteremia
Infections Caused by ESbL-Producing Enterobacteriaceae in Italy
To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1.
- Conditions
- Enterobacteriaceae Infections, Bacteremia, Pneumonia, Skin Diseases
- Trial name
- NCT00404625
- Testing
- Risk factors for infections due to ESBL+ Enterobacteriaceae, Risk factors for inadequate initial antimicrobial therapy, Overall and 30-day mortality in bad first antibiotic therapy
- Where
- 6 sites in Italy
- Volunteers
- 813 people
- Sponsor
- University of Siena
S. Aureus Bloodstream Infection
Collect Clinical Data in Chinese Patients Received CUBICIN Treatment for Actual Usage in Clinical Practice
This is a Multicenter, observational, non-interventional registry designed to collect clinical data in Chinese patients who have received CUBICIN treatment under condition of actual usage in clinical practice.
- Trial name
- NCT01212601
- Where
- 18 sites in China
- Volunteers
- 203 people
- Sponsor
- AstraZeneca
Sepsis, Emergent Infections, Treatment
Droplet Digital PCR Combines With Transcriptome Analysis in Early Warning of Sepsis in the Emergency Department
Rapid identification of pathogens and early warning of host response are key to improve the prognosis of sepsis. Establishing a comprehensive identification system based on pathogen identification and host immune status is an…
- Trial name
- NCT06028178
- Testing
- Droplet digital PCR
- Volunteers
- 360 people
- Sponsor
- Shanghai East Hospital
Oxidative Stress, Septic Shock
Clinical Trial of Antioxidant Therapy in Patients With Septic Shock
Sepsis and septic shock are public health problems worldwide that represents an excessive cost for health systems. Despite the great technological and research advances, mortality can reach up to 80% in patients with multiple…
- Trial name
- NCT03557229
- Testing
- Melatonin 5 mg, Vitamin C 1 GM Oral Tablet, Vitamin E 400 UNT
- Where
- Mexico
- Volunteers
- 131 people
- Sponsor
- American British Cowdray Medical Center
Pneumonia, Sepsis
Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and Sepsis
Pneumonia is a lung infection that can cause serious complications, especially when accompanied by sepsis. Sepsis can trigger excessive inflammation and abnormal blood clotting, potentially leading to organ damage and delayed…
- Conditions
- Pneumonia, Sepsis, Blood Coagulation Disorders
- Trial name
- NCT07892794
- Testing
- DLBS1033
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Sebelas Maret
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker
Phoenixin-14 Downregulation in Sepsis
Background: Sepsis is a leading cause of morbidity and mortality in intensive care units (ICUs) worldwide, accounting for millions of deaths annually.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker, Phoenixin-14 Molecular Downregulation
- Trial name
- NCT07356739
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Firat University
Sepsis
Study of Multiple-dose Kukoamine B Mesilate in Sepsis Patients
Phase I study of multiple-dose Kukoamine B Mesilate in Sepsis Patients
- Trial name
- NCT03237728
- Testing
- 0.06mg/kg,KB, 0.12mg/kg,KB, 0.24mg/,KB
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Tianjin Chasesun Pharmaceutical Co., LTD
Sepsis, Septic Shock
Esomeprazole to Reduce Organ Failure in Sepsis
Sepsis is a severe disease with a high mortality rate and lack of efficacious therapies. Proton pump inhibitors (PPI) are drugs widely used to inhibit acid secretion by gastric cells and with a high safety profile.
- Trial name
- PPI-SEPSIS (NCT03452865)
- Testing
- Esomeprazole
- Where
- 17 sites in Italy, Kazakhstan and 1 more
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Endotoxemia, Metabolic Syndrome
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health
The growing prevalence of obesity and type 2 diabetes (T2D) is a major public health problem. Recent studies have clearly established that the gut microbiota plays a key role in the investigator's propensity to develop obesity…
- Conditions
- Endotoxemia, Metabolic Syndrome, Glucose Metabolism Disorders, Insulin Resistance
- Trial name
- Phenulin (NCT03800277)
- Testing
- Cranberry, Agaves
- Where
- Canada
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Laval University
Newborn Sepsis
Clinical Criteria for a Pathogen in Term Newborn Suspected of Neonatal Sepsis
Neonatal early onset sepsis (EOS) diagnosis is difficult due to lack of sensivity and specificity markers. The investigators conduced a restrospectif study to all term born infants born between 1 january and 31 December 2013 and…
- Trial name
- IMF-NN (NCT03623503)
- Testing
- Observational study
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock
UK ANDROMEDA-Shock-2 RCT
The purpose of the trial is to test if a strategy of resuscitation guided by capillary refill time and individualised clinical hemodynamic phenotyping can improve important clinical outcomes within 28 days in septic shock…
- Trial name
- NCT06366854
- Testing
- Personalised fluid and haemodynamic resuscitation
- Volunteers
- 25 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Sepsis, Septic Shock
Clinical Efficacy of Megadose Vitamin C in Sepsis
In this multicenter, randomized, single-blind, placebo-controlled clinical trial. Patients will be randomly assigned to receive Vitamin C or placebo for 4 days or until ICU discharge (whatever come first).
- Trial name
- CEMVIS (NCT05194189)
- Testing
- Vitamin C, 5% glucose injection
- Where
- 4 sites in China
- Volunteers
- 234 people
- Sponsor
- Zhujiang Hospital