Clinical trials: Clinical Sepsis
Severe Sepsis
De-escalation of Empirical Antimicrobial Therapy Study in Severe Sepsis
Rational: Severe sepsis is one of the leading cause of mortality in intensive care unit patients. Early initiation of an appropriate empirical antimicrobial therapy is associated with improved outcomes.
- Trial name
- NCT01626612
- Testing
- continuation of the empirical antimicrobial therapy, streamlining of the empirical antimicrobial therapy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sepsis
Long-term Assessment of Patients Treated in the ICU for Sepsis
This study is a prospective, observational cohort clinical registry designed to describe clinical and epidemiological characteristics and outcomes of adult patients hospitalized with sepsis.
- Trial name
- LAPTUS (NCT07502794)
- Testing
- Usual Care
- Where
- Brazil
- Volunteers
- 760 people
- Sponsor
- Hospital Israelita Albert Einstein
Sepsis
Impact of Blood Culture Positivity Time on Clinical Management of Pediatric ICU Patients
Sepsis accounts for high morbidity and mortality rates in ICU globally. Early recognition of sepsis with appropriate antimicrobial therapy is critical for the appropriate management of patients (1).
- Trial name
- NCT05507957
- Testing
- direct reporting of time to positivity of blood culture to ICU to know its effect to patients managment
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Septic Shock
Hemodynamic Phenotype and Capillary Refill Time-targeted Resuscitation Strategy
Septic shock is associated with a high mortality risk. Fluid overload occurs when fluids are administered to fluid unresponsive patients, but also when inappropriate resuscitation goals are pursued.
- Trial name
- A2 (NCT05057611)
- Testing
- CRT-targeted strategy associated with a clinical hemodynamic phenotyping to personalize initial resuscitation in septic shock patients, Usual care (UC)
- Where
- Chile
- Volunteers
- 1,500 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Sepsis Syndrome, Septic Shock
Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis
Sepsis is a multifactorial syndrome characterized by a dynamic course and a clinical outcome dependent on several factors, and responsible for one in five deaths worldwide.
- Conditions
- Sepsis Syndrome, Septic Shock, Sepsis
- Trial name
- EPISEPSIS (NCT06446947)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Severe Sepsis, Severe Sepsis Without Septic Shock
Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol
This protocol will collect real-world data retrospectively from the electronic health record (EHR) as data obtained from the delivery of routine medical care to develop a machine learning (ML)-based Clinical Decision Support…
- Trial name
- NCT05304728
- Where
- 10 sites in United States
- Volunteers
- 40,000 people
- Sponsor
- Beckman Coulter, Inc.
Infection
Assessment of the Safety and Efficacy of Ciproxan-I.V. in Daily Clinical Practice - Analysis Results From a Post-marketing Surveillance
This study is a post-marketing surveillance in Japan, and it is a local prospective and observational study of patients who have received Ciproxan intravenously as a first-line treatment for sepsis, secondary skin infections…
- Trial name
- NCT01670435
- Testing
- Ciprofloxacin (BAYQ3939)
- Where
- Japan
- Volunteers
- 3,274 people
- Sponsor
- Bayer
Sepsis, Septic Shock
Erythromycin in Septic Patients: Immunomodulatory Role and Clinical Impact
In sepsis and septic shock, the host response is characterized by a complex of immune-inflammatory reactions; triggered and activated by microbial components.
- Conditions
- Sepsis, Septic Shock, Immunoinflammatory Response
- Trial name
- NCT04665089
- Testing
- Erythromycin
- Where
- Tunisia
- Volunteers
- 110 people
- Sponsor
- Tunis University
AIDS Pneumonia, Septic Shock
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
- Trial name
- NCT06145828
- Testing
- Cytokine Adsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
Sepsis
Mycobacterium w in Patients With Severe Sepsis
Recent evidence suggests that sepsis continuum includes an immune paralytic state, which may play a significant role in sepsis. Mycobacterium w by its TLR4 agonist activity may help in restoring immunity, thereby improving…
- Trial name
- MISS (NCT02330432)
- Testing
- Mycobacterium w, Best standard care
- Where
- India
- Volunteers
- 202 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sepsis, Acute Renal Failure
Inferior Vena Cava Collapsibility and Distensibility Assessment in Critical Care.
This study will help in determining the impact of assessment of Inferior Vena Cava Collapsibility and Distensibility Index (IVC CI and DI) through Point Of Care Ultra Sound (POCUS), for the fluid management of critically ill…
- Conditions
- Sepsis, Acute Renal Failure, Acute Gastroenteritis, Diabetic Ketoacidosis
- Trial name
- NCT06516692
- Testing
- Inferior Vena Cava Collapsibility/distensibility Index (IVC CI/DI) assessment
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Bacteremia, Intensive Care
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness
The World Health Organization, U.S. Centers for Disease Control and Prevention, Association of Medical Microbiology and Infectious Diseases (AMMI) Canada, and Health Canada have all declared antimicrobial resistance a global…
- Conditions
- Bacteremia, Intensive Care, Critically Ill, Sepsis
- Trial name
- BALANCE (NCT03005145)
- Testing
- 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.
- Where
- 68 sites in United States, Australia and 5 more
- Volunteers
- 3,622 people
- Sponsor
- Sunnybrook Health Sciences Centre
Peripheral Perfusion
Assessment of Peripheral Perfusion in the Critically Ill Patient
The purpose of this study is to evaluate PPI as a surrogate for clinical signs of peripheral perfusion in patients in septic shock and after cardiac surgery.
- Trial name
- CRTPPI (NCT02771002)
- Testing
- Peripheral Perfusion index by Carescape Patientenmonitor
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Periodontitis
Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols
Periodontitis is a chronic inflammatory disease of the periodontal tissues leading to the destruction of the tooth supporting structures.
- Trial name
- NCT07077122
- Testing
- Scaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser
- Where
- Greece
- Volunteers
- 75 people
- Sponsor
- National and Kapodistrian University of Athens
Bloodstream Infection
Efficacy and Safety of 7 Versus 14 Days of Antibiotic Treatment for Pseudomonas Aeruginosa Bacteraemia
Phase IV, open-labeled, randomized and multicenter clinical trial to demonstrate the superiority of antibiotics with authorized indication for 7 days versus 14 days in the treatment of bloodstream infections produced by P.
- Trial name
- SHORTEN2 (NCT05210439)
- Testing
- Short-treatment of any active antibiotic regimen, Long-treatment of any active antibiotic regimen
- Where
- 37 sites in Spain
- Volunteers
- 306 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Septic Shock, Sepsis
Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care
The purpose of this trial is to o assess feasibility of a protocol comparing conservative (trigger guided) vs. liberal (target guided) approach to fluid resuscitation in patients with septic shock after initial fluid…
- Trial name
- CLASSIC (NCT02079402)
- Testing
- Isotonic crystalloids
- Where
- 9 sites in Denmark, Finland
- Volunteers
- 153 people
- Sponsor
- Anders Perner
Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI)
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.
- Conditions
- Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP), Complicated Urinary Tract Infection (cUTI)
- Trial name
- CREDIBLE - CR (NCT02714595)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 85 sites in United States, Brazil and 14 more
- Volunteers
- 152 people
- Sponsor
- Shionogi
HIV Infections
A Study to Monitor Patients With Primary or Early HIV Infection
The purpose of this study is to monitor patients who recently have been infected with HIV in order to learn how their immune systems respond to HIV infection and to study how the virus acts in their bodies.
- Trial name
- NCT00000911
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Renal Failure, Infection
Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial
The primary objective of the study is to demonstrate the efficacy of 60% ethanol lock solution in preventing major catheter related infections in critically ill patients.
- Trial name
- ELVIS (NCT00875069)
- Testing
- Ethanol
- Where
- France
- Volunteers
- 1,460 people
- Sponsor
- University Hospital, Clermont-Ferrand
Altered Mental Status, Sepsis
Pre-hospital Ventilation Clinical Study
This study will collect and characterize ventilator use during patient care with a ZOLL 731 Series ventilator in a pre-hospital setting.
- Conditions
- Altered Mental Status, Sepsis, Heart Failure, Hemorrhage
- Trial name
- NCT05604430
- Testing
- 731 Series Ventilator
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Zoll Medical Corporation