Clinical trials: Clinical Stratification
Gastrointestinal Hemorrhage
Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance
The purpose of this research study is to measure the effect on of a large language model interface on the usability, attitudes, and provider trust when using a machine learning algorithm-based clinical decision support system in…
- Trial name
- NCT05816473
- Testing
- LLM
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Pain, Emergencies
Machine Learning for Risk Stratification in the Emergency Department (MARS-ED)
Rationale Identifying emergency department (ED) patients at high and low risk shortly after admission could help decision-making regarding patient care.
- Trial name
- MARS-ED (NCT05497830)
- Testing
- RISK-INDEX
- Where
- Netherlands
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Penicillin Allergy
Penicillin Allergy Delabeling Project
A investigational study to establish: 1. A validated cllinical pathway for delabeling declared Penicillin allergiy outside allergologic departments. 2.
- Trial name
- PenProv (NCT05090527)
- Testing
- Risk stratification
- Where
- 2 sites in Norway
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Breast Cancer
Implementing Polygenic Risk Scores for Breast Cancer Prevention: a Feasibility Study
This single-arm interventional feasibility study will evaluate whether integrating polygenic risk scores (PRS) into the CanRisk model can improve breast cancer risk prediction and personalized prevention in women at risk of…
- Trial name
- MIG (NCT06922708)
- Testing
- Clinical pathway for breast cancer prevention based on PRS-integrated CanRisk assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Cardiomyopathy, Hypertrophic
The Chinese Hypertrophic Cardiomyopathy Study(CHCS)
Hypertrophic cardiomyopathy (HCM) is one of the most common inherited cardiac diseases, with a prevalence of ∼0.2%. Sudden cardiac death (SCD), heart failure and stroke are the major poor outcomes of HCM.
- Trial name
- CHCS (NCT02696135)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Appendicitis
Pediatric Appendicitis Risk Calculator (pARC) in Children With Appendix Ultrasounds
Acute appendicitis (AA) is the most common condition requiring emergency surgery in children. At a network of institutions nationwide, a tool called the pediatric appendicitis risk calculator (pARC)1 is being studied to assess…
- Trial name
- NCT03522233
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Pharmacology, Clinical
Study on the Safety of Neladenoson Bialanate, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Dug Given as a Single Oral Dose of 10 mg Immediate Release Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight
Neladenoson bialanate is currently under clinical development for a condition in which the heart has trouble pumping blood through the body (chronic heart failure).
- Trial name
- NCT04320771
- Testing
- Neladenoson bialanate (BAY 1067197)
- Where
- 2 sites in Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bayer
Breast Neoplasms, Artificial Intelligence (AI)
Non-Contrast Breast MRI Diagnosis and Risk Stratification Using DWI-Generated Synthetic Contrast Enhancement
This study is conducted under the ethics-approved project titled "Artificial Intelligence Solution for Simplifying the Diagnostic Workflow of Breast MRI''.The goal of this observational study is to develop an integrated breast…
- Conditions
- Breast Neoplasms, Artificial Intelligence (AI), Magnetic Resonance Imaging (MRI), Diffusion Magnetic Resonance Imaging
- Trial name
- NCT07598084
- Testing
- Non-contrast breast MRI diagnostic model
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Colorectal Cancer
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC
The current study will compare the blood expression level of lncRNA NNT-AS1 and hsa-miR-485-5p, as well as heat shock protein 90 (HSP90) serum levels in both healthy and CRC Egyptian patients' cohort peripheral blood samples.
- Trial name
- NCT06531902
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Clinical Pharmacology
Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Impaired Liver Function and Healthy Participants Matched for Age-, Gender-, and Weight
BAY 63-2521 is intended to be used for a disease that affects the blood flow through the lungs. Renal impairment is a common condition in patients with this disease.
- Trial name
- NCT04366622
- Testing
- Riociguat (Adempas, BAY 63-2521)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Cardiovascular Diseases
Cardiovascular Disease Population Risk Tool
The purpose of this study is to develop, evaluate, and apply a predictive algorithm for assessing CVD risk in the community setting: the Cardiovascular Disease Population Risk Tool (CVDPoRT).
- Trial name
- CVDPoRT (NCT02267447)
- Volunteers
- 104,219 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Myocarditis, Ventricular Arrhythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOPED (NCT06591260)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis
Stratification and Treatment in Early Psychosis Study - PROMOTE
The purpose of this trial is: To investigate whether cannabidiol (CBD), compared to placebo, can reduce the severity of attenuated psychotic symptoms in individuals at clinical high risk for psychosis.
- Conditions
- Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis, Clinical High Risk for Developing Psychosis
- Trial name
- STEP-PROMOTE (NCT07434973)
- Testing
- Cannabidiol (CBD)
- Where
- 19 sites in Austria, Canada and 8 more
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cardiovascular Diseases, Cardiovascular Risk Factor
Stratification Protocols and Clinical, Physical and Biochemical Parameters to Forecast Cardiovascular Intercurrences.
Introduction: Despite the various beneficial effects, cardiovascular rehabilitation programs (CVRP) have been associated with the appearance of signs and symptoms.
- Trial name
- NCT03446742
- Testing
- Cardiovascular rehabilitation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Lung Cancer (Diagnosis)
Prospective Multicenter Cohort Study for the Development and Evaluation of Risk Stratification Tools for Lung Cancers and Their Postoperative Recurrences Using Multimodal Clinical, Radiological, Tissue and Longitudinal Biological Phenotyping Among People at Risk of Lung Cancer
Interventional study with minimal risks and constraints, involving annual assessment of the prevalence and incidence of lung cancer using low-dose contrast-free thoracic CT scans, immunological, inflammatory, metabolic, blood…
- Trial name
- LUCA-pi COHORT (NCT07042867)
- Testing
- biobanking, low dose scan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Thyroid Cancer, Large Language Models
Evaluation of an Artificial Intelligence-enabled Clinical Assistant to Support Thyroid Cancer Management
This study aims to evaluate the clinical feasibility of adopting artificial intelligence (AI)-based models to improve clinical management of thyroid cancer.
- Trial name
- NCT07234539
- Testing
- AI-enabled clinical assistant
- Where
- 2 sites in Hong Kong
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Clinical Pharmacology
Study on the Safety of BAY 63-2521, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug Given as a Single Oral Dose of 1 mg Tablet in Participants With Renal Impairment and Healthy Participants Matched for Age-, Gender-, and Weight
BAY 63-2521 is intended to be used for a disease that affects the blood flow through the lungs. Renal impairment is a common condition in patients with this disease.
- Trial name
- NCT04364464
- Testing
- Riociguat (Adempas, BAY 63-2521)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bayer