Clinical trials: Clinical Study
Healthy
Observational Study to Establish Patient-Matched Population Norms for the Multiple Sclerosis Cognition Assessment Battery
The primary objective of the study is to develop MS patient-matched healthy population norms for the Multiple Sclerosis Cognition Assessment Battery (MS-COG) that are representative of the United States (US), France, and Italy.
- Trial name
- NCT02283918
- Where
- 8 sites in United States, France and 1 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Biogen
Memory
Interviewing Children About Past Events: Evaluating the NICHD Interview Protocol
This study, conducted by the NICHD in collaboration with Lancaster University in Lancaster, England, will evaluate the accuracy of information obtained from children using AN ADAPTED VERSION OF NICHD's interview protocol.
- Trial name
- NCT00343018
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Virus Diseases, Hemorrhagic Fever, Ebola
Ad26.ZEBOV, MVA-BN-Filo Vaccination in Children and Adults Previously Vaccinated With Control in the EBOVAC-Salone Study
This is a Phase 2, open-label, study evaluating the safety and immunogenicity of the 2-dose vaccination regimen, Ad26.ZEBOV, MVA-BN-Filo, in adults and children originally enrolled in the control arm of the EBOVAC-Salone study
- Conditions
- Virus Diseases, Hemorrhagic Fever, Ebola, Infections, Hemorrhagic Fevers, Viral
- Trial name
- NCT05284097
- Testing
- Ad26.ZEBOV, MVA-BN-Filo
- Where
- Sierra Leone
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Laryngopharyngeal Reflux
Treatment of Extraesophageal Reflux With the Reza Band UES Assist Device
The purpose of the study is to determine the safety and effectiveness of non-invasive Reza Band UES Assist Device for the treatment of esophagopharyngeal reflux with extra-esophageal symptoms (chronic cough, choking, aspiration…
- Trial name
- NCT01857713
- Testing
- Reza Band UES Assist Device
- Where
- 5 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Somna Therapeutics, L.L.C.
Obesity
Study of Changes in Skeletal Muscle After Caloric Restriction
Research has shown that fat stored within muscles affects the muscle's sensitivity to insulin and ability to handle blood glucose.
- Trial name
- NCT00993460
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Bipolar Disorder, Schizophrenia
fMRI of Theory of Mind in Schizophrenia and Bipolar Disorder
Theory of mind (TOM), a main component of social cognition processes, refers to the capacity to infer one's own and other person's mental states.
- Trial name
- TOM-i (NCT02834182)
- Testing
- IRMf, Mini International Neuropsychiatric Interview, Positive And Negative Syndrom Scale
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Gait
Effect of Wearable Hip-Assist Robot on Reduction of Cardiopulmonary Metabolic Efficiency in Healthy Adults
The purpose of this study was to investigate the changes in muscle fatigue and respiratory metabolic energy expenditure during walking with wearable hip-assist robot (V3).
- Trial name
- NCT03484624
- Testing
- Treadmill walking
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Submental Fat
A Safety and Tolerability Study of 10XB-101 Injection in Adult Subjects With Submental Fat
The purpose of this research study is to determine the safety and efficacy of 10XB-101 vs. vehicle (placebo) for adults with excessive submental fat (SMF).
- Trial name
- NCT05154955
- Testing
- 10XB-101 Solution for Injection, 10XB-101 Vehicle Solution for Injection
- Where
- 4 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- 10xBio, LLC
Sleep Apnea, Obstructive
Intermitent Hypoxia and Its Pathophysiology Consequences in the Sleep Apnea-Hypopnea Syndrome.
Clinical trial on the effect of continuous positive pressure (CPAP). Objectives: 1) To assess the total or partial recovery of oxidative and inflammatory damage after recovering IH.
- Trial name
- NCT04444778
- Testing
- CPAP
- Where
- 2 sites in Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alberto Alonso Fernandez
Induced Abortion
Study of Sublingual Versus Oral Misoprostol Administration Following Mifepristone 200 mg for Abortion up to 63 Days Gestation
This open-label, randomized study is being conducted to determine whether a dose of 400 mcg of sublingual misoprostol (i.e., under the tongue) taken 24 hours following administration of mifepristone 200 mg is effective and…
- Trial name
- NCT00286208
- Testing
- Mifepristone, misoprostol
- Where
- 9 sites in Moldova, Tunisia and 1 more
- Volunteers
- 1,443 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Optic Nerve Sheath Diameter
The Effects of Lateral 45° Downward Position on the Optic Nerve Sheath Diameter
Trendelenburg position and carbon dioxide (CO2) pneumoperitoneum are in association with increased intracranial pressure (ICP) reflected by the optic nerve sheath diameter (ONSD).
- Trial name
- NCT05185908
- Testing
- Measurement of the optic nerve sheath diameter by ultrasound-guidance.
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Low Back Pain
Study to Evaluate the Effectiveness of Orthopedic Spinal Supports in the Treatment of Low Back Pain
The purpose of this study is to determine whether orthopedic spinal supports are effective in the treatment of low back pain.
- Trial name
- NCT00553540
- Testing
- Back supports
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cleveland Clinic Florida
Gout, Hyperuricemia
Relative Bioavailability Study to Assess an LC350189 Tablet Compared to an LC350189 Capsule in Healthy Adults
This is an open-label, randomized, crossover, single dose study. Two single doses of LC350189(tablet or capsule formulations) will be administered with a washout period of at least 4-day between the doses to investigate the…
- Trial name
- NCT04886050
- Testing
- LC350189 Tablet, LC350189 Capsule
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- LG Chem
Smoking Cessation
Testing Different Theories of Smoking Cessation: An Intervention Study
The topic of this research is cigarette smoking cessation. We designed four smoking cessation booklets. These booklets are designed for smokers who differ in their motivation to quit smoking.
- Trial name
- NCT01209897
- Testing
- Smoking cessation booklet
- Where
- United States
- Volunteers
- 1,826 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
SARS-CoV-2, COVID-19
A Study on the Safety and Immune Response of Investigational COVID-19 mRNA Vaccines in Healthy Adults
The purpose of Part A of this study is to assess the immune response and safety of a booster dose of investigational COVID-19 mRNA vaccines in healthy adults.
- Trial name
- NCT05960097
- Testing
- CV0701 mRNA COVID-19 Vaccine (Low dose), CV0701 mRNA COVID-19 Vaccine (Medium dose), CV0701 mRNA COVID-19 Vaccine (High dose)
- Where
- 17 sites in United States, Australia
- Volunteers
- 692 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Breast Cancer
Decellularized, Whole Donor Nipple-Areola Complex Reconstruction Grafts
The goal of this study is to evaluate safety and healing time after nipple-areolar complex (NAC) reconstruction with the BioAesthetics' decellularized human nipple-areolar complex (dcl-hNAC) graft in patients who have had…
- Trial name
- NCT04534010
- Testing
- NACgraft
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy
A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants
This is an open-label, 2-cohort study to evaluate the mutual DDI potential between denifanstat and resmetirom in healthy adult participants.
- Trial name
- NCT07216313
- Testing
- Denifanstat, Resmetirom
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sagimet Biosciences Inc.
Smallpox
Dose Study of ACAM2000 Smallpox Vaccine in Previously Vaccinated Adults
The objective of this study is to determine the minimum dose of ACAM2000 needed to produce a cutaneous reaction in at least 90% of a population of healthy adults at least 28 years of age and previously vaccinated against smallpox.
- Trial name
- NCT00053482
- Testing
- ACAM2000 Smallpox Vaccine, Vaccinia virus (calf lymph) smallpox vaccine: Dryvax®
- Where
- 3 sites in United States
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
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