Clinical trials: Clinical Study
AI Companionship
How Do Artificially Intelligent Companions Influence Psychological Outcomes?
This randomized longitudinal study examines how interacting with an artificially intelligent (AI) companion affects psychological well-being, social experiences, and interpersonal attitudes and behaviors over time.
- Trial name
- NCT07858279
- Testing
- AI Companion Interaction
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hidradenitis Suppurativa
To Assess the Efficacy and Safety of Adalimumab in Subjects With Moderate to Severe Hidradenitis Suppurativa
The trial is a 12-week phase 2 study. Subjects will be given subcutaneous injections at weeks 0 (160mg), 2 (80mg), and then every other week (40mg) until week 12 in subjects with moderate to severe hidradenitis suppurativa.
- Trial name
- HIDRI2007 (NCT00827996)
- Testing
- adalimumab
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Florida Academic Dermatology Centers
Chronic Pain
Effects of Pain on Driving Performance and Cognition.
It has been suggested that cognitive functioning is impaired in chronic pain patients. Since most of these pain patients engage in daily activities including driving, it was hypothezised that they may have an increased risk of…
- Trial name
- NCT00189046
- Testing
- driving and laboratory tests
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Healthy Volunteer
A Study of RO5190591 (Danoprevir) in Healthy Volunteers
This non-randomized, open-label study will evaluate the interaction of RO5190591(danoprevir)/ritonavir with and without ketoconazole and the safety and tolerability in healthy volunteers.
- Trial name
- NCT01164488
- Testing
- danoprevir, ketoconazole, ritonavir
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight
Study of Grape Consumption in Adaptation to Seasonal Photoperiod
The goal of this randomized clinical trial is to learn whether consuming grapes during their natural season can help the body adapt to the shorter daylight hours of winter.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight, Obesity & Overweight
- Trial name
- PhotoGrape (NCT07886788)
- Testing
- Freeze-Dried Grape Powder, Plain Low-Fat Yogurt, Mediterranean-Style Dietary Guidance
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Depression, Pain
Paroxetines Effect on Tramadols Metabolism and Pharmakodynamics: a Dose Response Study
The purpose of the study is to examine the connection between the dose of paroxetine and the effect of paroxetine on tramadols metabolism and thereby the effect of tramadol on the median pupil size.
- Trial name
- NCT00785603
- Testing
- Paroxetine, Tramadol
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Cytomegalovirus Infections
Safety and Immunogenicity of the Human Cytomegalovirus (CMV) Vaccine (V160) in Healthy Japanese Men (V160-003)
The purpose of the study is to assess the safety and tolerability of a 3-dose regimen of V160 administered by intramuscular (IM) injection in healthy Japanese male participants by cytomegalovirus (CMV) serostatus.
- Trial name
- NCT03840174
- Testing
- V160
- Where
- Japan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers
The study investigated the bioequivalence between the new and the approved formulation for levothyroxine.
- Trial name
- NCT03979274
- Testing
- Reference Eutirox®, Test Eutirox®
- Where
- Mexico
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Pharmacokinetics
Clinical Study on Rapid Antioxidant Protection and Immune Modulating Effects.
A trial on acute antioxidant protection and immune effects when 24 people consume a novel nutraceutical blend compared to a placebo on different test days.
- Trial name
- NCT05042674
- Testing
- Ergothioneine, 25 miligrams, Ergothioneine, 25 miligrams, daily for 1 week
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Natural Immune Systems Inc
Healthy
A Study of SPY002-091 in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single- dose, first in human safety, tolerability, and pharmacokinetic study of SPY002-091 in healthy participants.
- Trial name
- NCT06672718
- Testing
- SPY002-091
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Spyre Therapeutics, Inc.
HIV Infection, Infection, Human Immunodeficiency Virus
Healthy Volunteer Study To Assess The Bioavailability of GSK1265744 When Administered Orally Either When Fasted or Following a Meal.
To evaluate the single dose relative bioavailability of GSK1265744 10mg administered in either oral solution fasted, two 5mg tablets fasted, or two 5mg tablets following a moderate meal.
- Trial name
- NCT00812318
- Testing
- GSK1265744 10 mg oral solution, GSK1265744 5 mg tablet
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Cardiovascular Diseases, LDL-cholesterol
Evaluation of a Probiotic on LDL-cholesterol Levels
The aim of the present study is to evaluate the ability of Bifidobacterium BSL_PS404 in reducing LDL-cholesterol levels in healthy individuals.
- Trial name
- NCT04029818
- Testing
- Bifidobacterium BSL_PS404
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Biosearch S.A.
Sleep Apnea, Snoring
Epigenetics Modifications in Obstructive Sleep Apnea
Changes in epigenetic regulation of genes involved in systemic inflammation and metabolic dysfunction in OSA are linked with accelerated cardiovascular morbidity.
- Trial name
- EPIOSA (NCT02131610)
- Where
- Spain
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Aragon Institute of Health Sciences
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Bowel Cleansing Prior to Colonoscopy
Efficacy Study of Bowel Preparation Before Colonoscopy
The purpose of this study is to determine the efficacious dose range when used as a bowel preparation before colonoscopy.
- Trial name
- NCT00621920
- Testing
- FM-601
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- C.B. Fleet Company, Inc.
COVID-19, Coronavirus Infection
Relative Bioavailability Study of CX2101A for the Treatment of COVID-19
The study comprises three parts: single ascending dose (SAD) studies of CX2101A tablets at 40 mg, 100 mg, and 160 mg; a relative bioavailability (BA) study comparing single-dose administration of 100 mg CX2101A tablets and…
- Trial name
- NCT06864182
- Testing
- CX2101A tablet, CX2101A enteric-coated tablet
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heronova Pharmaceuticals
Pelvic Floor, Abdominal Muscles
Effectiveness of Abdomino-pelvic Muscle Contraction Education Programme in Healthy Male University Students
This research study investigates the effectiveness of an educational intervention aimed at improving awareness and control of pelvic floor (PF) and abdominal muscle contractions in healthy young male university students.
- Conditions
- Pelvic Floor, Abdominal Muscles, Abdominal Muscles/ultrasonography
- Trial name
- NCT06786182
- Testing
- PFM Educational Program
- Where
- Spain
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- European University of Madrid
Glaucoma, Open-Angle
Trabeculectomy Versus 2-iStent and Prostaglandin Study
Investigators hypothesize that the synergistic action of iStent in increasing aqueous outflow through the trabecular meshwork and use of prostaglandin analog such as travoprost or latanoprost to increase uveoscleral outflow will…
- Trial name
- TIPS (NCT03274323)
- Testing
- iStent and travoprost or latanoprost, Trabeculectomy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Post-Operative Confusion, Neuroinflammatory Response
Neuroinflammation and Alzheimer's Pathology in POCD
The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (POCD).
- Conditions
- Post-Operative Confusion, Neuroinflammatory Response, Alzheimer Disease
- Trial name
- POCD (NCT05378659)
- Testing
- Montreal Cognitive Assessment, Stroop Test, 4AT Delirium
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Tuberculosis
Biological Samples Obtained by Leukapheresis Induced by Two BCG Vaccinations in BCG-naïve Healthy Adults in the US
This protocol will use leukapheresis to collect lymphocytes to study immune responses following vaccination with BCG in BCG-naïve participants.
- Trial name
- (A-051) (NCT03175380)
- Testing
- bacillus Calmette-Guérin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aeras
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