Clinical trials: Closed Loop, active
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07775807
- Testing
- Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Muscle Fatigue, Functional Electrical Stimulation
Recumbent Cycling and Functional Electrical Stimulation for Lower Limb Rehabilitation
This study evaluates two different control strategies for a rehabilitation device that combines recumbent leg-cycling with functional electrical stimulation (FES) of the quadriceps muscle.
- Conditions
- Muscle Fatigue, Functional Electrical Stimulation, Neuromuscular Rehabilitation
- Trial name
- BiciFES (NCT07873424)
- Testing
- Fatigue-Feedback FES Control Strategy, Standard FES Control Strategy
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Upper Extremity Dysfunction After the Stroke
Individualized rTMS Synchronized Task Training for Closed-loop Neuromodulation of Post-stroke Motor Dysfunction
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase…
- Trial name
- rTMS (NCT07049211)
- Testing
- Individualized online stimulation, Non-individualized online stimulation
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Ruijin Hospital
Diabetes Mellitus, Type 1
Starting Technology in At Risk Type 1 Diabetes Study
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c>8.5%).
- Trial name
- STAR-T1D (NCT06453928)
- Testing
- Hybrid Closed Loop Insulin Pump System
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Essential Tremor
Responsive Deep Brain Stimulator for Essential Tremor
Essential tremor is an incurable, degenerative brain disorder that results in increasingly debilitating tremor, and afflicts an estimated 7 million people in the US.
- Trial name
- NCT02649166
- Testing
- Deep brain stimulation, Closed-loop deep brain stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Stroke
Assessment of the Functional Impact of a Close-loop Controlled Prehension Neuroprosthesis in Post-stroke Patients
The aim of the PREHENS-STROKE study is to propose a functional replacement device to restore grip capacities in patients with hemiparesis after stroke, unable to actively open the hand to seize objects.
- Trial name
- PREHENS-STROKE (NCT04804384)
- Testing
- Prehension neuroprosthesis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Type 1 Diabetes (T1D), Type 2 Diabetes
Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery
The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care…
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- PREPARE 4 AID (NCT07011147)
- Testing
- Bionic Pancreas, Routine Care
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus Type 1
HOME-AHCL: Home-Based Implementation of an Advanced Hybrid Closed-Loop System With Telemonitoring in Type 1 Diabetes
The goal of this prospective, single-arm observational study is to characterise a home-based setup and telemonitoring care model for an advanced hybrid closed-loop insulin pump system (Tandem Control-IQ) in adults with type 1…
- Trial name
- HOME-AHCL (NCT07492992)
- Where
- 3 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Air Liquide Healthcare Spain
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Major Depression, Sleep
Sleep TMS for Depression
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
- Trial name
- NCT06824415
- Testing
- TMS
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Refractory Obsessive-Compulsive Disorder
The goal of this clinical trial is to learn if deep brain stimulation (DBS) works to treat refractory obsessive-compulsive disorder (OCD).
- Trial name
- NCT06660225
- Testing
- Medtronic Percept Deep Brain Stimulation Therapy [Therapeutic stimulation]
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nader Pouratian
Major Depressive Disorder (MDD)
Neurofeedback to Treat Depression - 2
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD.
- Trial name
- NCT07159061
- Testing
- Active Closed Loop Real Time fMRI Neurofeedback
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Type 1 Diabetes, Type 2 Diabetes
Closed Loop Glucose Control in a Simulated ICU Setting
This is a proof of concept safety study of a rule-based closed loop glucose control system designed for use in the intensive care unit setting.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Stress Induced Hyperglycemia
- Trial name
- NCT07646067
- Testing
- FUSION closed loop glucose control system
- Volunteers
- 6 people
- Sponsor
- Ideal Medical Technologies
Non-invasive Brain Stimulation, Methodologic Study
Closed-loop Non-invasive Brain Stiumlation
Transcranial magnetic stimulation (TMS) is a widely used tool for exploring brain function in humans (Siebner et al. et al., 2022), which has led to new therapeutics for various psychiatric and neurological disorders (Lefaucheur…
- Trial name
- CLOSEDLOOP (NCT06600217)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes.
- Trial name
- WBH002 (NCT05653518)
- Testing
- Tandem t:slim X2 with Control-IQ Technology, Sensor augmented pump (SAP) therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
T2DM Patients With Traumatic Brain Injury
Hybrid Closed-Loop System in Neurosurgical Perioperative Hyperglycemia: An Open RCT
In this study, we plan to use an open-source hybrid closed-loop artificial pancreas system and a combination of a traditional insulin pump and continuous glucose monitoring (CGM) respectively to conduct short-term intensive…
- Trial name
- NCT06909071
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanxi Bethune Hospital
Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus
Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes
The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery.
- Conditions
- Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus, Insulin, Ketones
- Trial name
- WBH003 (NCT07186660)
- Testing
- CIR-0602K
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Post-stroke Hemiparesis
Innovative Closed-loop Functional Electrical Stimulation Control System for Augmenting Post-stroke Gait
This study will compare the performance of a novel data-driven model-predictive controller (MPC) based functional electrical stimulation (FES) system versus a conventional FES system for footdrop correction during treadmill and…
- Trial name
- NCT07189819
- Testing
- Model-Predictive Controller (MPC) Functional Electrical Stimulation (FES), Conventional Functional Electrical Stimulation (FES)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Type 1 Diabetes
Fully Closed Loop At Home (FCL@Home)
Protocol Overview/Synopsis This study will be conducted at 3 sites, with each site performing a session with up to 6 participants with a lower HbA1c (<8.0%) in one of 3 age categories (26-60, 18-25, or 14-17 years) followed by a…
- Trial name
- NCT06041971
- Testing
- AIDANET system
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes (T1D)
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes Who Are Using Hybrid Closed Loop (HCL) Systems
TTP399-206 is a Phase 2a multicenter double blind cross over randomized study of cadisegliatin in participants with T1D using hybrid closed loop systems to manage their diabetes.
- Trial name
- Hybrid CATT1 (NCT07616206)
- Testing
- Cadisegliatin 800 mg QD
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- vTv Therapeutics