Clinical trials: Closed-loop Brain Stimulation
Mild Cognitive Impairment, Alzheimer Dementia (AD)
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in older adults with and without cognitive impairment.
- Trial name
- NCT05907343
- Testing
- Closed-loop TBS, Open-loop TBS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stroke
Functional Impact of a Closed-loop Controlled Grasping Neuroprosthesis in Post-stroke Patients (PREHENSTROKE)
Stroke is the leading cause of disability in adults. The improvement of the grasp abilities remains a challenge in the 50% of post-stroke subjects who have not recovered functional grasping due to paralysis of the finger's…
- Trial name
- PREHENSTROKE (NCT03946488)
- Testing
- Functional electrical stimulation
- Where
- 2 sites in France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Parkinson Disease(PD)
Adaptive DBS for PD
The goal of this clinical trial is to evaluate the efficacy and safety of an adaptive deep brain stimulation (aDBS) system for managing Parkinson's disease symptoms.
- Trial name
- SMART-DBS (NCT07635823)
- Testing
- adaptive deep brain stimulation, conventional deep brain stimulation
- Where
- 9 sites in China
- Volunteers
- 60 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Parkinson's Disease
LFP Correlates of Movement Disorders
The purpose of this study is to record electrical brain activity during DBS surgery and after DBS surgery using the Medtronic Activa PC+S deep brain stimulation (DBS) system, a modified DBS pulse generator.
- Trial name
- NCT02115802
- Testing
- Activa PC+S
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Colorado Neurological Institute
Major Depressive Disorder
Closed-Loop Deep Brain Stimulation for Major Depression
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry.
- Trial name
- PReSiDio (NCT04004169)
- Testing
- Stimulation-ON, Stimulation-OFF, Stimulation-ON Active Control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Andrew Krystal
Parkinson Disease
Scalar Closed Loop Intraoperative Study
The purpose of this study is to measure neural activity during deep brain stimulation (DBS). There are two types of neural activity that we will record from DBS electrodes during this study: DBS local evoked potentials (DLEPs)…
- Trial name
- NCT03270657
- Testing
- IPG; RC+S
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dennis Turner, M.D.
Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects…
- Trial name
- CL-tACS RCT (NCT06874374)
- Testing
- Closed-loop tACS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Pulvinar Neuro, LLC
Parkinson's Disease (PD)
Movement State-dependent Adaptive DBS for PD
This is a single-center clinical study aiming to improve gait functions in patients with Parkinson's Disease (PD) by using adaptive neurostimulation to the pallidum.
- Trial name
- NCT07424508
- Testing
- Summit RC+S
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Doris Wang, MD, PhD
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Optimal Dosing
This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD).
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07461584
- Testing
- 1-day patterned tACS, 3-day patterned tACS, 5-day patterned tACS
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Treatment-Refractory Schizophrenia
Deep Brain Stimulation for Psychosis
There are three hypotheses proposed for this study: 1) Participants will report no unanticipated serious adverse events during the eight months of treatment.
- Trial name
- NCT06257056
- Testing
- Abbott Laboratories Infinity™ implantable deep brain stimulation system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Bradley Lega
Ischemic Stroke
Combined taVNS and tDCS in Subacute Stroke Patients
Ischemic stroke, the most prevalent neurological disorder, is treated with medication and thrombectomy but with limited success, especially in chronic stages where traditional rehabilitation is the primary option.
- Trial name
- NCT06244914
- Testing
- tDCS stimulation, taVNS stimulation
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Cheng-Kung University Hospital
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Epilepsy
Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver…
- Trial name
- NCT06898138
- Testing
- Brain Interchange System
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Parkinson Disease, Dystonia
The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy
This is an exploratory pilot study to identify neural correlates of specific motor signs in Parkinson's disease (PD) and dystonia, using a novel totally implanted neural interface that senses brain activity as well as delivering…
- Trial name
- NCT03582891
- Testing
- Summit RC+S for Motor, 8-week pilot trial of Closed-loop vs. Open-loop Stimulation, Summit RC+S for Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Sinus Node Disease
Clinical Benefits of the Closed Loop Stimulation in Sinus Node Disease
The study is designed as a multi-center, international, prospective, parallel, randomized, single blinded trial comparing the time to first primary endpoint event (Sustained Paroxysmal AF/Persistent AF or stroke/TIA) occurrence…
- Trial name
- B3 (NCT02579889)
- Testing
- DDD+CLS, DDD(R)
- Where
- 54 sites in China, Hungary and 7 more
- Volunteers
- 1,390 people
- Sponsor
- Biotronik SE & Co. KG
Depression
Brain-oscillation Synchronised Stimulation of the Prefrontal Cortex
Combining TMS and EEG, this study investigates a personalized therapeutic non-invasive brain stimulation protocol in patients with major depression, whereby the timing of the TMS pulses is synchronized with the instantaneous…
- Trial name
- BOSSFRONT (NCT02920840)
- Testing
- Intermittent theta-burst stimulation, Negative-peak-triggered-TMS, Open-loop replay TMS
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- University Hospital Tuebingen
Parkinson's Disease (PD), Tremor
Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage.
- Trial name
- tACS_PD_TR (NCT06993571)
- Testing
- Active-tACS, Unlocked-tACS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Epilepsy, Sleep
Effect of Auditory Stimulation on Spike Waves in Sleep
Background: Close relationship exists between sleep slow wave (SSW) and the generation of spike wave in NREM-sleep. SSW are cortically generated oscillations alternating between excitatory depolarization ("Up-phase" of the SSW)…
- Trial name
- ECLASS (NCT02562885)
- Testing
- Acoustic pulses
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University Children's Hospital, Zurich
Epilepsy, Seizures
Closed-loop System Using Transcranial Direct Current Stimulation (tDCS) for Epilepsy
In this pilot study, the researchers investigated the feasibility of a closed-loop electroencephalography (EEG) / transcranial direct current stimulation (tDCS) system for treatment of epilepsy.
- Trial name
- NCT01415362
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Stroke
taVNS for Upper Limb Rehabilitation
This study explores the use of a new form of neuromodulation known as transcutaneous auricular vagus nerve stimulation (taVNS) which stimulates the ear.
- Trial name
- NCT04129242
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) + Task Specifc Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina