Clinical trials: Cluster Detection
Cancer Colorectal
Impact of EDUcation Strategy on Patients With COLorectal CANCER or Advanced Adenoma in the Detection of Colorectal Cancer of Their First-degree Relatives
The relative risk of colorectal cancer (CRC) is increased in first-degree relatives of patients with CRC or advanced adenoma. In the high-risk CCR population defined by a family history at the first stage of CRC or advanced…
- Trial name
- EDUCANCOLAGE (NCT03084133)
- Testing
- Therapeutic Education Strategy
- Where
- 8 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Tours
Breast Neoplasms, Early Detection of Cancer
Breast Ultrasound Screening in Elderly Women: A Multicenter Cluster Randomized Trial
This multicenter, cluster randomized trial will evaluate whether community-based breast ultrasound screening improves the early detection of breast cancer in women aged 65 to 80 years, compared with routine health management.
- Trial name
- NCT07698366
- Testing
- Standardized Breast Ultrasound Screening
- Where
- 2 sites in China
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Tuberculosis
Can Screening People Registering With Primary Care Improve the Detection of Tuberculosis?
This randomised controlled trial tests whether screening people registering with general practices cost-effectively increases the detection of tuberculosis. The study objectives are to: 1.
- Trial name
- NCT00214708
- Testing
- Screening for Tuberculosis
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Anaemia
A Trial of 2 'Point of Care' Diagnostic Methods to Improve Detection and Treatment of Anaemia in African Children
A high proportion of children under the age of 5 years and pregnant women in Tanzania is anaemic, particularly in areas of high malaria transmission.
- Trial name
- EARS (NCT00439595)
- Testing
- Hemocue 210 meter, Copack HBCS
- Where
- Tanzania
- Volunteers
- 450 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Nasopharyngeal Cancer, Screening
Cluster Randomized Controlled Screening Trial for NPC
This study is aimed to estimate the effectiveness of an Epstein-Barr virus (EBV) serology-based screening program to reduce nasopharyngeal carcinoma (NPC) mortality in a cluster randomized controlled trial in an NPC high-risk…
- Conditions
- Nasopharyngeal Cancer, Screening, Morality
- Trial name
- CRCSTNPC (NCT00941538)
- Testing
- Experimental: Screening with EBV VCA/EBNA1-IgA testing
- Where
- 2 sites in China
- Volunteers
- 87,600 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Delirium, Intensive Care Unit Delirium
Family-partnered Delirium Prevention, Detection, and Management in the ICU
Almost half of critically ill patients experience delirium. Delirium is associated with impaired cognition, mortality, and increased healthcare costs.
- Conditions
- Delirium, Intensive Care Unit Delirium, Post Intensive Care Unit Syndrome, Post Intensive Care Unit Syndrome Family
- Trial name
- ACTIVATE (NCT07896356)
- Testing
- Standard of Care, Delirium Education, Prevention, and Management
- Where
- Canada
- Volunteers
- 1,344 people
- Sponsor
- University of Calgary
Tuberculosis, HIV
Engaging Informal Health Care Providers on Case Detection and Treatment Initiation Rates for TB and HIV in Rural Malawi (Triage Plus)
The intervention consisted of training non-paid informal healthcare providers (such as store-keepers) in TB and HIV disease recognition, sputum specimen collection, referral to the public health system, and raising community…
- Trial name
- Triage (NCT02127983)
- Testing
- Early intervention, Delayed intervention
- Where
- Malawi
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Depression, Anxiety
Mental Health Promotion Interventions Among Migrant Workers in China
The goals of this research were to conduct a mental health intervention study for reducing self-reported depression and anxiety among migrant workers in a labor-intensive industry in China and to assess the effectiveness of the…
- Trial name
- NCT02009358
- Testing
- mental health promotion
- Volunteers
- 913 people
- Sponsor
- Peking University
Valvular Heart Disease Patients, Aortic Stenosis
Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)
Heart valve disease and weakened heart muscle (left ventricular systolic dysfunction) are common in older adults and often go undetected until serious complications such as heart failure develop.
- Conditions
- Valvular Heart Disease Patients, Aortic Stenosis, Mitral Regurgitation, Left Ventricular Diastolic Dysfunction
- Trial name
- IMPROVE (NCT07756398)
- Testing
- Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.)
- Where
- 2 sites in United States
- Volunteers
- 1,088 people
- Sponsor
- University of Texas Southwestern Medical Center
Melanoma, Screening
Comparison of Two Strategies for Counseling Skin Examination and Sun Protection in First-degree Relatives of Patients With Melanoma
First-degree relatives of patients with melanoma have a greater risk of developing melanoma. Patients are advised orally to inform their first-degree relatives that they should protect their skin from UV radiation and ask for a…
- Trial name
- FADEMELA (NCT02917473)
- Testing
- In-person counseling, Written advice, Medical skin screening
- Where
- 9 sites in France
- Volunteers
- 420 people
- Sponsor
- University Hospital, Tours
Post-Partum Haemorrhage
A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Every six minutes a mother dies from postpartum haemorrhage (PPH) in low-resource countries, in the prime of her life and often leaving behind a young family.
- Trial name
- E-MOTIVE (NCT04341662)
- Testing
- E-MOTIVE intervention, Usual care
- Where
- 6 sites in Kenya, Nigeria and 3 more
- Volunteers
- 99,659 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Malignant Tumor of Cervix, Cervical Intraepithelial Neoplasia
Participation in Screening for Cervical Cancer: Interest of a Self-sampling Device Provided by the General Practitioner
This study evaluates the benefit in women aged from 30 to 65 years, who do not participate to the French opportunistic cervical cancer screening program, of an organized screening with the proposition by the family physician of a…
- Trial name
- PaCUDAHL-Gé (NCT02749110)
- Testing
- Vaginal self-sampling brush
- Where
- France
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Cesarean Delivery
The Effectiveness of a Care Bundle to Prevent Postpartum Hemorrhage After Cesarean Delivery
Delays in the detection or inconsistent use of effective interventions of postpartum hemorrhage can result in complications or death.
- Trial name
- RE-TEAM (NCT06684080)
- Testing
- A care bundle
- Volunteers
- 52,000 people
- Sponsor
- Dunjin Chen
Tuberculosis
Effect of Community Active Case Finding Strategies for Detection of Tuberculosis in Cambodia
Tuberculosis (TB) is a highly stigmatized disease, and approximately one-third of the Cambodian population living with TB are undetected.
- Trial name
- NCT04094350
- Testing
- ACF with a seed-and-recruit model, ACF targeting household and neighborhood contacts, ACF targeting the older population using mobile screening units
- Where
- 3 sites in Cambodia
- Volunteers
- 2,004 people
- Sponsor
- National University of Singapore
Heart Failure, Heart Valve Diseases
Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope
Heart failure (HF) is a condition in which the heart cannot pump blood adequately. It is increasingly common, consumes 4% of the UK National Health Service (NHS) budget and is deadlier than most cancers.
- Conditions
- Heart Failure, Heart Valve Diseases, Atrial Fibrillation, Heart Murmurs
- Trial name
- TRICORDER (NCT05987670)
- Testing
- AI-stethoscope
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Early Warning Score, Risk Stratification
Individual Early Warning Score (I-EWS)
Early Warning Score (EWS) is a clinical scoring system used in hospitals in Denmark and internationally to systematically observe admitted patients using a standardised response algorithm.
- Trial name
- NCT03690128
- Testing
- I-EWS with incorporated clinical assessment (Trigger Tool), Standard EWS - Control (Trigger Tool)
- Where
- 8 sites in Denmark
- Volunteers
- 150,000 people
- Sponsor
- Herlev Hospital
Cirrhosis
A Study to Detect Advanced Liver Disease Via AI-enabled Electrocardiogram
The overall objectives of this study are to determine the effectiveness of ACE 2.0 model in early detection of advanced liver fibrosis, and to determine the acceptance and barriers for use of an AI-enabled algorithm for…
- Trial name
- ADVANCE (NCT05782283)
- Testing
- ACE (AI-Cirrhosis-ECG) 2.0
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Mayo Clinic
Irreversible Loss of Brain Function (ILBF)
Automated Screening for Clinically Ascertained Loss of Cerebral Functions
Rationale: The low organ donation rate in Germany is associated with the inadequate identification of patients at risk of developing irreversible loss of brain function (ILBF; i.e. brain death).
- Trial name
- DETECT-IVE (NCT06293170)
- Testing
- DETECT, Conventional care
- Where
- Germany
- Volunteers
- 4,800 people
- Sponsor
- Technische Universität Dresden
COVID-19
Community-Based Health Education Programs for the Early Detection of, and Vaccination Against, COVID-19 and the Adoption of Self-Protective Measures of Hong Kong Residents
This study evaluates the community-based health education program in improving early testing for COVID-19, increasing vaccination acceptability and enhancing emergency preparedness and self-protection measures against COVID-19 in…
- Trial name
- NCT05539482
- Testing
- Community-based Health Education based on core intervention package, Health Information Sharing Group
- Where
- Hong Kong
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Intracranial Aneurysm, CT Angiography
Stepped-Wedge Cluster Randomized Trial of AI-Assisted CTA Detection for Intracranial Aneurysms in Regional Hospitals
This study (IDEAL 2) is a nationwide stepped-wedge cluster-randomized trial designed to prospectively enroll over 14,400 patients undergoing outpatient head CT angiography (CTA).
- Conditions
- Intracranial Aneurysm, CT Angiography, AI (Artificial Intelligence), Cluster Randomized Trial
- Trial name
- IDEAL2 (NCT07124624)
- Testing
- AI-Assisted CTA Interpretation, Standard CTA Interpretation
- Volunteers
- 14,400 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China