Clinical trials: Coagulation; Intravascular
Disseminated Intravascular Coagulation
Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment
To investigate the impact of impaired renal function on the pharmacokinetics of ART-123 in patients with Disseminated Intravascular Coagulation.
- Trial name
- NCT01704001
- Testing
- ART-123
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Asahi Kasei Therapeutics Corporation
Disseminated Intravascular Coagulation
Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis
The primary objective of the study is to explore the efficacy and safety of ATryn® (antithrombin alfa) for the treatment of disseminated intravascular coagulation (DIC) associated with severe sepsis, when administered by…
- Trial name
- NCT00506519
- Testing
- Antithrombin alfa (INN name), Control (Standard treatment)
- Volunteers
- 25 people
- Sponsor
- LEO Pharma
Disseminated Intravascular Coagulation (DIC)
A Phase 3 Clinical Study of KW-3357 in Patients With DIC
To evaluate the efficacy and safety of KW-3357 with concomitant use of heparin using multi-center, non-comparative, open-label method in patients diagnosed as disseminated intravascular coagulation (DIC) by Japanese Association…
- Trial name
- 3357-006 (NCT01384409)
- Testing
- KW-3357
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Disseminated Intravascular Coagulation (DIC)
A Clinical Study of KW-3357 in Patients With DIC
To evaluate the efficacy and safety of KW-3357 with concomitant use of heparin using multi-center, non-comparative, open-label method in patients diagnosed as disseminated intravascular coagulation (DIC) by the diagnostic…
- Trial name
- 3357-005 (NCT01384396)
- Testing
- KW-3357
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Severe Sepsis
4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock
Data on 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene are limited in Asian patients with sepsis. Therefore, the investigators aim to prospectively investigate the incidence of 4G/5G polymorphism and its…
- Trial name
- NCT01211899
- Volunteers
- 160 people
- Sponsor
- Hallym University Medical Center
COVID, Disseminated Intravascular Coagulation
Coagulation Changes Associated With COVID-19 Infection
This study will study the potential utility of the Quantra QPlus System in patients inflicted with COVID-19 disease.
- Conditions
- COVID, Disseminated Intravascular Coagulation, Coagulation Disorder
- Trial name
- NCT04460664
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- HemoSonics LLC
Coagulation; Intravascular, Rotational Thromboelastometry
The Effect of Tranexamic Acid on Blood Coagulation in Total Hip Arthroplasty Surgery
Total hip arthroplasty (THA) is associated with blood loss ranging from 300 to 2000 mL. Tranexamic acid (TXA) is frequently administered prophylactically during this procedure to reduce blood loss by inhibiting fibrinolysis or by…
- Conditions
- Coagulation; Intravascular, Rotational Thromboelastometry, Fibrinolysis; Hemorrhage, Tranexamic Acid
- Trial name
- NCT03897621
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK
EVALUATION OF NEUTROPHIL FLUORESCENCE IN PATIENTS WITH DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK
Neutrophil fluorescence could be a reliable and early diagnostic marker of disseminated intravascular coagulation septic DIC, which can be used routinely.
- Trial name
- HEMATOCLOT (NCT07039487)
- Testing
- Blood sampling collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Snakebite, Coagulopathy, Consumption
Waveform Analysis In Snakebite Victims With Hematotoxicity
In hematotoxic snakebites, due to the lack of a better alternative, 20 minute whole blood clotting test (20'WBCT) or Clotting time remains the standard test in developing countries even though its reliability and sensitivity has…
- Trial name
- WISH (NCT03859154)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Coagulation Factor Deficiency, Coagulopathy, Consumption
Effect of Vitamin K in Critically Ill Patients
Critically ill patients with spontaneously prolonged pro-thrombin time, where administration of intravenous administration of phytomenadione (vitamin K) has been ordered by the treating physician will be identified.
- Conditions
- Coagulation Factor Deficiency, Coagulopathy, Consumption, Vitamin K Deficiency
- Trial name
- VITAKOAG (NCT03782025)
- Testing
- Phytomenadione
- Where
- 2 sites in Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Sepsis Associated Disseminated Intravascular Coagulation (DIC)
A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers.
This study is designed to evaluate a new investigational drug, BAY 3389934, in healthy Japanese volunteers. The primary purpose is to see how safe the drug is and how well it is tolerated by the body when given at different…
- Trial name
- NCT07176728
- Testing
- BAY 3389934
- Where
- 2 sites in Japan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Disseminated Intravascular Coagulation, Critical Illness
Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical Infections
Inflammation and abnormalities in laboratory coagulation tests are inseparably tied. For example, coagulation abnormalities are nearly universal in septic patients.
- Conditions
- Disseminated Intravascular Coagulation, Critical Illness, Sars-CoV2, Viral Infection
- Trial name
- NCT04356144
- Testing
- Thrombin Generation Assay (TGA), Thrombomodulin Modified Thrombin Generation Assay (TGA-TM)
- Where
- Austria
- Volunteers
- 58 people
- Sponsor
- Medical University of Vienna
Septic Shock, Coagulopathy
Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study
No randomized controlled trial (RCT) has investigated the effect of prophylactic fresh frozen plasma (FFP) transfusion in septic or critically ill patients with coagulation abnormalities.
- Conditions
- Septic Shock, Coagulopathy, Disseminated Intravascular Coagulation
- Trial name
- PlasmaFaisa (NCT04580563)
- Testing
- OctaplasLG®, 0.9% NaCl
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Cardiac Arrest
Intravascular Clotting (POCUS) - Marker of the Timing and Severity of Cardiac Arrest; Indicator of Futile Resuscitation
The scientific goals of the project: 1. ultrasound assessment of the incidence of clotting in deep veins in patients after cardiac arrest during resuscitation and after the declaration of death; comparison to the incidence of…
- Trial name
- NCT06406920
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Shock, Septic
Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock
Evaluates whether the DIC score, as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC
- Trial name
- NCT06581172
- Testing
- D_dimer
- Volunteers
- 80 people
- Sponsor
- Assiut University
Gastric Cancer, Bone Marrow Metastasis
Infusional Fluorouracil and Weekly Docetaxel for Gastric Cancer With Bone Marrow Involvement and DIC
A distinctive subtype of gastric adenocarcinoma with extensive bone marrow metastasis and DIC has been described. Few patients have been treated properly due to the lack of standard care.
- Conditions
- Gastric Cancer, Bone Marrow Metastasis, Disseminated Intravascular Coagulation
- Trial name
- NCT04547153
- Testing
- 5-fluorouracil, Docetaxel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Sepsis, Sepsis Associated DIC
A Study to Learn About the Occurrence of Disseminated Intravascular Coagulation in People With Sepsis and Further Worsening of Sepsis
This is an exploratory study in which data from people with sepsis (a serious condition in which the body responds to an infection that damages vital organs) admitted to an Intensive care unit (ICU) who will receive treatment are…
- Trial name
- NCT06986798
- Testing
- Local standard medical care
- Where
- 31 sites in Austria, Belgium and 5 more
- Volunteers
- 150 people
- Sponsor
- Bayer
COVID, Vitamin D Deficiency
The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations
Although the novel SARS-CoV-2 virus (COVD-19) is classified as an acute respiratory infection, emerging data show that morbidity and mortality are driven by disseminated intravascular coagulopathy.
- Conditions
- COVID, Vitamin D Deficiency, Coagulopathy, Disseminated Intravascular Coagulation
- Trial name
- LEAD COVID-19 (NCT04363840)
- Testing
- Aspirin 81 mg, Vitamin D
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Sepsis, Disseminated Intravascular Coagulation (DIC)
Fluorescent Leukocytes as a Marker of Early Sepsis/Severity
Sepsis is a medical emergency whose prognosis depends on the early identification of patients at risk of septic shock, but the tools available in the Emergency Department remain insufficient.
- Conditions
- Sepsis, Disseminated Intravascular Coagulation (DIC), Septic Shock
- Trial name
- FLAMES (NCT07585942)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Disseminated Intravascular Coagulation
Thrombin Generation and Thromboelastography in Non-overt DIC
Sepsis is the 13th most common cause of death in the United States, causing approximately 210,000 deaths per year. Once DIC has developed, irreversible organ injury has already occurred and the mortality rate is 70%.
- Trial name
- NCT00299949
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston