Clinical trials: Coagulation; Intravascular
Sepsis, Disseminated Intravascular Coagulation
Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation
The primary objective of this study is to estimate the efficacy of unfractionated heparin(UFH) on ICU mortality in severe sepsis with suspected DIC.The Second objective is to estimate the effect of UFH on 28-day mortality,and the…
- Trial name
- NCT02654561
- Testing
- Heparin Sodium, Saline
- Where
- 17 sites in China
- Volunteers
- 600 people
- Sponsor
- China Medical University, China
Purpura, Thrombocytopenic, Idiopathic
Rapid Infusion Of Immune Globulin Intravenous (IGIV) In Patients With ITP
The objective of this study is to determine if the safety and tolerability of Immune Globulin Intravenous (Human), 10% Caprylate/Chromatograph Purified (IGIV-C) is similar when infused at two different infusion rates.
- Trial name
- NCT00220727
- Testing
- Immune Globulin IV [Human], 10% Caprylate/Chromatography Purified
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Grifols Therapeutics LLC
Septic Shock, Thrombocytopenia
Platelet Reactivity in Septic Shock
Coagulation disorders and thrombocytopenia are common in patients with septic shock. Despite the clinical relevance of sepsis-induced thrombocytopenia, few studies have focused on the prediction of thrombocytopenia in this…
- Conditions
- Septic Shock, Thrombocytopenia, Sepsis, Platelet Aggregation
- Trial name
- NCT03716310
- Testing
- platelet responsiveness evaluation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
DIC Syndrome
Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa
Evaluation of the use of thromboelastometry for early identification of the underlying coagulopathy and to guide individualized transfusion therapy to prevent DIC development during ICU stay after cesarean section in women with…
- Trial name
- DIC (NCT03266432)
- Testing
- blood samples
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Snake Bites, Coagulopathy, Consumption
Hemostatic Variables In Snakebite Study
Background Novelty The global assays of coagulation, namely the viscoelastometric tests and clot waveform has never been studied in detail before in snakebite victims.
- Trial name
- HISS (NCT04520282)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Acute Lung Injury, Metabolic Disturbances
Acute Lung Injury After Cardiac Surgery: Pathogenesis
The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.
- Conditions
- Acute Lung Injury, Metabolic Disturbances, Inflammation, Coagulation; Intravascular
- Trial name
- ALI (NCT02475694)
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Aalborg University Hospital
Disseminated Intravascular Coagulation
The Proactive Diagnostic Value of Hemostatic Biomarkers in Disseminated Intravascular Coagulation
The project was undertaking by Qilu Hospital of Shandong University, aiming to evaluate diagnostic performance of hemostatic biomarkers in disseminated intravascular coagulation.
- Trial name
- NCT05995093
- Testing
- no intervention
- Where
- China
- Volunteers
- 462 people
- Sponsor
- Qilu Hospital of Shandong University
Septic Shock, Platelet Signal Processing Defect
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock
Knowing the dramatic increase in thrombin generation during sepsis, our research hypothesis is that AMPK-induced ACC phosphorylation in platelets is increased and that this might modulate platelets metabolism and more…
- Conditions
- Septic Shock, Platelet Signal Processing Defect, Inflammatory Response, Disseminated Intravascular Coagulation
- Trial name
- PLACCSEPS (NCT04107402)
- Testing
- Assessment of coagulopathy, Platelets activation and Platelets-Neutrophils interplay
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sepsis, Coagulopathy
A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy
Researchers are looking for a better way to treat people who have sepsis induced coagulopathy. Sepsis happens when bacteria and their toxins spread in the blood, causing an infection.
- Trial name
- NCT06854640
- Testing
- BAY3389934
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 36 people
- Sponsor
- Bayer
Disseminated Intravascular Coagulation (DIC), Reanimation
EARLY DIAGNOSIS OF SEPTIC DIC
Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice.
- Conditions
- Disseminated Intravascular Coagulation (DIC), Reanimation, Septic Shock
- Trial name
- EASY-DIC (NCT07630415)
- Where
- France
- Volunteers
- 492 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Disseminated Intravascular Coagulation
An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults With Sepsis in Japan
This is an observational study in which data already collected from people with sepsis (blood poisoning) and/or disseminated intravascular coagulation (DIC) are studied.
- Trial name
- NCT06373159
- Testing
- No study intervention
- Where
- Japan
- Volunteers
- 5,740 people
- Sponsor
- Bayer
Critical Illness, Kidney Replacement Disorder
Compare Efficacy and Simplicity of Regional Citrate Anticoagulation With Fixed Dose Versus Adjusted Citrate Program
Anticoagulation is required to prevent clotting in the extracorporeal circuit during continuous renal replacement therapy (CRRT). Regional citrate anticoagulation has many advantages regarding bleeding risk and filter survival.
- Conditions
- Critical Illness, Kidney Replacement Disorder, Coagulation; Intravascular
- Trial name
- NCT02663960
- Testing
- fixed citrate doses protocol, adjusted citrate doses protocol
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
Pit Viper Bite, Coagulopathy
Thrombelastography for Coagulopathy in Chinese Snakebites
This study aims to evaluate the coagulation disorders caused by pit viper bites in patients from Zhanjiang and surrounding areas.
- Conditions
- Pit Viper Bite, Coagulopathy, Thromboelastography (TEG), Venom-induced Consumptive Coagulopathy
- Trial name
- NCT06860503
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Sepsis, Septic Shock
Rotational Thromboelastometry Versus DIC Score in Sepsis
Sepsis results in activation of the coagulation system, which is commonly described as disseminated intravascular coagulation (DIC).
- Trial name
- RODSS (NCT04610853)
- Testing
- rotational thromboelastometry
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Disseminated Intravascular Coagulation
International Prospective Registry of Disseminated Intravascular Coagulation
Objectives: to evaluate the current diagnostic and therapeutic approaches for sepis-associated disseminated intravascular coagulation (DIC) in a large prospective registry.
- Trial name
- NCT03577015
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Marcella Muller
Prostate Hyperplasia, Coagulation; Intravascular
The Effect of Human Prostate Tissue on Platelet Activation
Transurethral resection of the prostate (TURP) is a common and standard urological surgical procedure for managing benign prostatic hyperplasia (BPH).
- Conditions
- Prostate Hyperplasia, Coagulation; Intravascular, Thrombotic Disorder
- Trial name
- NCT05059431
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Covid19, COVID-19 Respiratory Infection
Standardized Olive Leaf Capsules; as a Co-therapy in the Treatment of COVID-19 Patients
Starting from December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused a tremendous economic loss and unprecedented health crisis across the globe.
- Conditions
- Covid19, COVID-19 Respiratory Infection, Symptoms and Signs, COVID-19 Acute Bronchitis
- Trial name
- NCT04873349
- Testing
- Nusapure standardized olive leaves capsule, 750 mg (50% oleuropein)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Shimaa M. Abdelgawad
Sepsis, Venous Thromboembolism
An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related
This is an observational study in which data already collected from people with venous thromboembolism (VTE) due to sepsis (blood poisoning) are studied.
- Conditions
- Sepsis, Venous Thromboembolism, Disseminated Intravascular Coagulation
- Trial name
- NCT06765681
- Testing
- Diagnosis of both VTE and sepsis
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Bayer
Renal Failure
Effect of a Pre Heparin Coated Dialysis Filter on Coagulation During Hemodialysis
The purpose of this study is to determine whether the heparin-coated dialysis filter is superior to a conventional filter during hemodialysis in twelve stable, chronic hemodialysis (HD) patients.
- Trial name
- NCT01388270
- Testing
- a pre-heparin-coated hemodialysis filter; Hepran
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Oslo University Hospital
Disseminated Intravascular Coagulation, Neonates
Predictive Value of Scoring System in Neonates with Disseminated Intravascular Coagulation
The aims of this study were to investigate underlying diseases associated with neonatal DIC diagnosed on the first 28 days of life, and whether DIC score could predict mortality in neonates.
- Trial name
- NCT06626880
- Volunteers
- 43 people
- Sponsor
- Assiut University