Clinical trials: Coal Worker's Pneumoconiosis
Pneumoconiosis
The Experience of Patients and Family Caregivers in Managing Pneumoconiosis in the Family Context
This is an exploratory qualitative study to understand the needs of patients with pneumoconiosis, and the care-giving experience of their family caregivers.
- Trial name
- NCT04022902
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 83 people
- Sponsor
- Chinese University of Hong Kong
Silicosis
Comprehensive Risk Assessment of People With Silicosis: A Population-based Study
Objectives: This study aims to explore the risk profiles among people with silicosis in Hong Kong underpinned by the Pittsburgh Mind-Body Center model.
- Trial name
- NCT02794701
- Testing
- People with silicosis
- Where
- China
- Volunteers
- 390 people
- Sponsor
- Chinese University of Hong Kong
Pneumoconiosis Coal, Asbestosis
The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial
Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis. Subjects will be treated with Nintedanib 150mg twice daily for 3 years.
- Conditions
- Pneumoconiosis Coal, Asbestosis, Silicosis
- Trial name
- NiPPs (NCT04161014)
- Testing
- Nintedanib 150 MG [Ofev]
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Holdsworth House Medical Practice
Chronic and Accelerated Silicosis
Safety of Stem Cells Intrabronchial Instillation for Silicosis
The aim of this study was to analyze the safety, pulmonary function, and quality of life data of patients with silicosis treated with intrabronchial instillation of bone marrow derived mononuclear cells (BMDMC, 2x107) through…
- Trial name
- SilicStemCell (NCT01239862)
- Testing
- Autologous cell transplantation
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Silicosis
Using Silica 12CH to Mitigate the Effects and Symptoms of Silicosis in Brazil
This clinical study aims to address a research and clinical treatment gap related to individuals with symptoms of Silicosis resulting from quartzite mining work.
- Trial name
- HOHM (NCT06011785)
- Testing
- Silica 12CH
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- HOHM Foundation
Cerebral Amyloid Angiopathy, Siderosis
Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy
Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging…
- Trial name
- CSS (NCT05394636)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 111 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sarcoidosis, Berylliosis
Identifying Shared Genetic Susceptibility Regions in Chronic Beryllium Disease and Sarcoidosis
Granulomatous lung diseases are diseases in which inflamed clusters of white cells, known as granulomas, form in lung tissue. Chronic beryllium disease (CBD) and sarcoidosis are two granulomatous diseases that share similar…
- Trial name
- NCT00560989
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Jewish Health
Iron Deposition, Dialysis
Iron Deposits in the Pancreas by MRI Method of Dialysis Patients With Hemosiderosis Iatrogenic (ERDFP)
Recently, a multidisciplinary scientific conference proposed to consider iron overload in dialysis patients as pathological only in the event of demonstration of radiological (in MRI), pancreatic or cardiac ferric deposits.
- Conditions
- Iron Deposition, Dialysis, Iatrogenic Hemosiderosis
- Trial name
- ERDFP (NCT05593068)
- Testing
- MRI
- Where
- France
- Volunteers
- 185 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Siderosis
A Prospective Safety Follow Up Study Of Subjects Enrolled In Study A4321001 And Who Have Received Drug Product
This protocol intends to detail investigations necessary to evaluate the ocular safety of subjects enrolled in study A4321001 and who have received formulated Drug Product (Lot 8716-098).
- Trial name
- NCT00471224
- Testing
- Observational Trial
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Pfizer
Pneumoconiosis
Human Umbilical Cord-Mesenchymal Stem Cells for Pneumoconiosis
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for Pneumoconiosis.
- Trial name
- NCT02790762
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Pneumoconiosis
Potential of Deep Learning in Assessing Pneumoconiosis Depicted on Digital Chest Radiography
Pneumoconiosis is relatively prevalent in low/middle-income countries, and it remains a challenging task to accurately and reliably diagnose pneumoconiosis.
- Trial name
- NCT04963348
- Testing
- convolutional neural networks (CNNs)
- Volunteers
- 1,881 people
- Sponsor
- Peking University Third Hospital
Chronic Beryllium Disease
Targeting Oxidative Stress in Chronic Beryllium Disease
The purpose of this study is to understand if a drug called mesalamine helps to control inflammation associated with chronic beryllium disease (CBD).
- Trial name
- NCT01088243
- Testing
- Mesalamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Jewish Health
Asbestosis
Pirfenidone Use in Asbestosis Patients: Efficacy and Prognosis
This study aims at determining the the efficiency and prognosis of using pirfenidone drug among asbestosis patients.
- Trial name
- NCT05133453
- Testing
- Pirfenidone
- Volunteers
- 40 people
- Sponsor
- Cairo University
Berylliosis, Beryllium Disease
Beryllium Infliximab Study: Clinical Interventional Trial
The goal of this research study is to test the clinical effectiveness of a drug called infliximab (Remicade) in chronic beryllium disease (CBD).
- Trial name
- BISCIT (NCT00111917)
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Maier, Lisa, M.D.
Lung Diseases, Obstructive, Asbestosis
Specialized Center of Research in Occupational and Immunologic Lung Disease
The overall objective of the Center was to develop a scientific data base for the control and prevention of acute and chronic lung injury caused by the inhalation of a variety of agents in the workplace and in the environment.
- Conditions
- Lung Diseases, Obstructive, Asbestosis, Silicosis, Pneumoconiosis
- Trial name
- NCT00005280
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Transplant, Lung Resection
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders
The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used.
- Conditions
- Lung Transplant, Lung Resection, Lung Cancer, Asthma
- Trial name
- NCT02748798
- Testing
- HP 3He, HP 129Xe, PFP
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Thunder Bay Regional Health Research Institute
Silicosis, Pneumoconiosis; Silica
Screening Strategy for Early Diagnosis of Silicosis in At-Risk Populations in Oklahoma
Silicosis, a preventable yet irreversible occupational lung disease, has an insidious onset with a latency period for diagnosis extending beyond 10 years from the initial exposure.
- Trial name
- NCT04205708
- Testing
- Tuberculosis test, Chest X-ray, Pulmonary Function Test
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of Oklahoma
Pneumoconiosis
Efficacy and Safety of Pirfenidone Capsules in the Treatment of Pneumoconiosis
This study is a randomized, double-blind, placebo-controlled, multicenter clinical study. The main purpose of this study was to confirm the efficacy and safety of pirfenidone capsules in the treatment of pneumoconiosis.
- Trial name
- NCT05288179
- Testing
- Pirfenidone Capsules
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Tobacco Use Cessation, Tobacco Use Disorder
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Coal miners in Central Appalachia have among the highest rates of tobacco and nicotine product (TNP) use of any occupational group and face elevated rates of lung cancer and coal workers' pneumoconiosis ("black lung").
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
- Trial name
- NCT07694492
- Testing
- QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Silicosis
The SHIELD Whole Lung Lavage Study
An observational cohort study that will assess the efficacy of Whole Lung Lavage in workers with silicosis or silica-induced bronchitis.
- Trial name
- SHIELD (NCT05402176)
- Testing
- Whole Lung Lavage
- Where
- 4 sites in Australia
- Volunteers
- 30 people
- Sponsor
- The University of Queensland