Clinical trials: Cocaine
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine Dependence
A Placebo-Controlled Double-Blind Combined Treatment of Modafinil and CBT for Cocaine Dependence
The purpose of this study is to test whether a cognitive behavioral therapy (CBT) and a medication called modafinil, which is approved to treat sleep disorders, will help individuals who are abusing cocaine.
- Trial name
- NCT00344565
- Testing
- Modafinil, Cognitive Behavioral Therapy--Relapse Prevention
- Volunteers
- 15 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence, Opioid Dependence
Levetiracetam (Keppra) Tolerability in Cocaine Abusing Methadone-maintained Patients.
The proposed investigation will use methadone maintained patients who have concurrent cocaine dependence in order to take advantage of the excellent (over 80%) treatment retention in this patient group and to maximize treatment…
- Trial name
- Keppra (NCT00593125)
- Testing
- levetiracetam
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Yale University
Training for Cocaine Use Disorder
A Trial Of Approach Bias Modification Training During Treatment For Cocaine Use Disorder
The goal of this clinical trial is to investigate if the intervention "Approach Bias Modification" (ABM) can low cocaine craving in people with Cocaine Use Disorder (CUD).
- Trial name
- ABMCocaine (NCT07033416)
- Testing
- Approach Bias Modification, Treatment as usual
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- ASST Fatebenefratelli Sacco
Cocaine Use Disorder
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
The purpose of this study is to assess effects of intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham on electrophysiological…
- Trial name
- NCT05986578
- Testing
- TMS to dmPFC, TMS to dlPFC
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Use Disorder
A Feasibility Trial for Inhibitory-Control Training to Reduce Cocaine Use
Cocaine abuse is an unrelenting public-health concern. Behavioral therapies are considered the "standard of care" for reducing cocaine use and preventing relapse.
- Trial name
- RCT(01) (NCT02444208)
- Testing
- Active Inhibitory Control Training, Neutral Inhibitory Control Training
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cocaine Use Disorder
Imaging CRF X NOP Interactions in CUD
This study uses [11C]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in…
- Trial name
- NCT05008146
- Testing
- Baseline [C-11]NOP-1A PET Scan, Hydrocortisone, Post-hydrocortisone [C-11]NOP-1A PET Scan
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rajesh Narendran
Hiatal Hernia With Gastroesophageal Reflux Disease
Comparison of Laparoscopic Nissen Fundoplication and Hill-Snow Repair for Hiatus Hernia With Endoscopic Evaluation
The goal of this clinical trial is to compare the clinical efficacy and safety of laparoscopic Nissen fundoplication (LNF) versus laparoscopic Hill-Snow repair (LHS) in the management of patients with congenital hiatus hernia, to…
- Trial name
- NCT07387042
- Testing
- Laparoscopic Hill-Snow repair, Laparoscopic Nissen Fundoplication
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Drug Abuse, Cocaine Dependence
Reward Processing in Cocaine Addiction
Background: Cocaine affects the brain's ability to process information. However, different people respond to cocaine in different ways, and differences in brain structure and function may affect how cocaine alters brain activity.
- Trial name
- NCT01036074
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Cocaethylene as a Treatment for Cocaine Dependence - 1
Cocaine has been cited as the primary drug threat in the United States. The purpose of this study is to determine if cocaethylene, used as a prototype drug, is a safe and effective treatment for cocaine dependence.
- Trial name
- NCT00124696
- Testing
- Cocaethylene
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Epistaxis
Xylometazoline and Cocaine for Nasal Vasoconstriction
The objective of this study is to compare xylometazoline and cocaine's effect on minimizing epistaxis when administered as a local vasoconstrictor prior to nasal intubation.
- Trial name
- NCT05334017
- Testing
- Xylometazoline 0,1%, Cocaine 4%
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Alcoholism, Cocaine Dependence
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol and cocaine dependence.
- Trial name
- NCT00218660
- Testing
- Naltrexone, BRENDA, CBT
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- University of Pennsylvania
Alcohol-Related Disorders, Cocaine-Related Disorders
Disulfiram for Cocaine-Alcohol Abuse - 3
The purpose of this study is to evaluate disulfiram for cocaine-alcohol abuse.
- Trial name
- NCT00000278
- Testing
- Disulfiram
- Where
- United States
- Sponsor
- Yale University
Cocaine Use, Cocaine Dependence
Effect of rTMS on Neurotrophines Levels in CUD
Brief Summary: Background: Cocaine use disorders (CUD) is a multifactoral disease, involving several brain areas. One of the most investigated is the Dorsolateral Prefrontal Cortex (DLPFC) involved in impulsiveness control.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Abuse, Neurotropism
- Trial name
- BDNFcoca (NCT05824221)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine Dependence
Citalopram for Cocaine Dependence
This is a phase 2 clinical trial of citalopram pharmacotherapy for treatment of cocaine dependence. Using a double-blind, randomized controlled design, eligible cocaine dependent patients will be assigned equally to one of three…
- Trial name
- NCT01535573
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Joy Schmitz
Cocaine, Substance Abuse
The Maternal Lifestyle Study (MLS)
This is a longitudinal, multi-site observational study of the long-term effects of a mother's use of cocaine and/or opiates during pregnancy on her infant.
- Conditions
- Cocaine, Substance Abuse, Infant, Newborn, Pregnancy
- Trial name
- MLS (NCT00059540)
- Where
- 5 sites in United States
- Volunteers
- 11,811 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Craving, Emotional Dysfunction
Process of Regulation in Addictions: Vulnerability Emotional Factors to Craving
The aim of this study is to have a better understanding of the relationship between self-controle difficulties (and more specifically the inhibition deficit in impulsivity), emotional regulation disorders such as alexithymia and…
- Conditions
- Craving, Emotional Dysfunction, Self-Regulation, Emotion, Alexithymia
- Trial name
- Procrav (NCT05076201)
- Testing
- Patients with completed rehab
- Where
- France
- Volunteers
- 80 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Cocaine-Related Disorders
Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the treatment of cocaine dependence using reserpine, gabapentin, or lamotrigine vs. an unmatched placebo control.
- Trial name
- NCT00015106
- Testing
- Lamotrigine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine-Related Disorders
Progesterone for the Treatment of Cocaine Dependence - 1
Past research has demonstrated that cocaine dependent women experience less severe responses to cocaine during the luteal phase of the menstrual cycle, when estrogen and progesterone concentrations are high.
- Trial name
- NCT00218257
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Minnesota