Clinical trials: Cocaine
Cocaine Use Disorders
Glutamatergic Modulation of Motivation Enhancement: A Pilot Feasibility Trial
This study evaluates the feasibility of a treatment paradigm that involves naturalistic cocaine use opportunities in the context of psychotherapy aimed at utilizing these opportunities therapeutically.
- Trial name
- NCT02373124
- Testing
- infusion of NMDA antagonist
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Addiction
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
The investigators' recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other…
- Trial name
- NCT01822587
- Testing
- Propranolol, 40 mg, Propranolol, 80 mg
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Medical University of South Carolina
Cocaine Use Disorder, Anxiety
Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use
The purpose of this study is to determine the effectiveness of a medication called suvorexant in reducing anxiety, improving sleep, and reducing cocaine cravings or cocaine use.
- Trial name
- NCT02785406
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Use Disorders, HIV
Project IMPACT: Improving Memory Performance by Applying Cognitive Training
The purpose of this study is to examine the effects of a cognitive training program in persons with Human Immunodeficiency Virus (HIV) infection who have used cocaine.
- Trial name
- NCT02909101
- Testing
- Active Cognitive Training (ACT), Control Training (CON)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Alcoholism, Cocaine Dependence
Vigabatrin for Cocaine and Alcohol Dependence
The purpose of this study is to evaluate the effectiveness of vigabatrin at reducing drug and alcohol use in individuals addicted to cocaine and alcohol. Vigabatrin is approved for the treatment of seizures.
- Trial name
- VGB (NCT01335867)
- Testing
- Vigabatrin
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
The purpose of this study is to see if a drug called Candesartan will help to reduce use of cocaine.
- Trial name
- NCT01938664
- Testing
- Candesartan with CBT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
The Efficacy of Doxazosin for Cocaine Users
Doxazosin, an alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine dependent participants.
- Trial name
- NCT00880997
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
A Phase II Trial of Varenicline for the Treatment of Cocaine Dependence
This is a double-blind placebo-controlled clinical trial (n = 156) of varenicline for the treatment of cocaine dependence that utilizes contingency management to promote treatment attendance.
- Trial name
- NCT01680887
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Pharmacogenetics of Doxazosin for Cocaine Dependence
Doxazosin, an alpha 1-adrenergic receptor antagonist, may play an important role in cocaine addiction in humans. This study will evaluate to what extent the prospective screening for catecholamine related polymorphisms for alpha…
- Trial name
- NCT01145183
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Baylor College of Medicine
Cocaine Use Disorder
Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
This study will determine the initial efficacy of phendimetrazine as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study will be conducted in which the subjective, physiological and reinforcing…
- Trial name
- BED IN 31 (NCT02522325)
- Testing
- Phendimetrazine, Cocaine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- William Stoops
Cocaine Dependence
Impact of a Non-Drug Choice on Cocaine Reinforcement
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for…
- Trial name
- NCT01906346
- Testing
- Cocaine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cocaine Dependence
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse…
- Trial name
- NCT01535937
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Glutamatergic Modulation of Cocaine-related Deficits
Cocaine dependence involves problematic neuroadaptations, such as heightened reactivity to cocaine cues, that may be responsive to pharmacological modulation of glutamatergic circuits.
- Trial name
- NCT01790490
- Testing
- Ketamine 0.41 mg/kg, Ketamine 0.71 mg/kg, Lorazepam 2 mg
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the brain.
- Trial name
- NCT00134901
- Testing
- Memantine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Atomoxetine for Treating Cocaine Abuse in Adults With Attention Deficit Hyperactivity Disorder (ADHD)
Studies have shown that individuals with attention deficit hyperactivity disorder (ADHD) are at greater risk for having a substance use disorder compared to people who do not have ADHD.
- Trial name
- Atom (NCT00218543)
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
The proposed protocol is a double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) and topiramate in the treatment of cocaine dependence.
- Trial name
- TACT (NCT00421603)
- Testing
- Adderall-XR and Topiramate
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Adult Attention Deficit Hyperactivity Disorder, Cocaine Dependence
Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
The proposed protocol is a 3 group double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (ER-MAS) in the treatment of comorbid ADHD and cocaine dependence.
- Trial name
- CAMP (NCT00553319)
- Testing
- Adderall-XR
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence
The proposed protocol is an open-label pilot study of the treatment of cocaine dependence using lisdexamfetamine (LDX), a prodrug of d-amphetamine.
- Trial name
- Vyvance (NCT01486810)
- Testing
- Lisdexamfetamine, medication management
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
The proposed protocol is a multi-site double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (MAS-ER) and topiramate in the treatment of cocaine dependence.
- Trial name
- TACT2 (NCT01811940)
- Testing
- Adderall-ER, Topiramate
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- New York State Psychiatric Institute
Active Cocaine Users
Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for…
- Trial name
- NCT02383043
- Testing
- Cocaine, Sustained Release d-Amphetamine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Joshua A. Lile, Ph.D.