Clinical trials: Cocaine
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Use Disorder
Treatment With Lorcaserin for Cocaine Use: The TLC Study
This project is a placebo-controlled, double-blind randomized trial evaluating the feasibility, tolerability, acceptability and adherence for lorcaserin among actively using, men who have sex with men (MSM) with cocaine use…
- Trial name
- TLC (NCT03192995)
- Testing
- lorcaserin, Substance use counseling, ACASI
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Glenn-Milo Santos
Cocaine Related Disorders
Contingency Management Treatment for Crack Addiction - Study With Brazilian Population
Crack addiction has become a severe health problem in Brazil. Today, crack addiction is the primary cause for inpatient treatment for all illicit substances.
- Trial name
- NCT01815645
- Testing
- ST+CM, standard treatment
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Federal University of São Paulo
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer program.
- Trial name
- NCT00809835
- Testing
- Galantamine, Computer Assisted Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Cocaine Use Disorders
Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine
Cocaine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce cocaine use, however, these interventions are not universally effective and treatment…
- Trial name
- NCT01639157
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- William Stoops
Alcohol Use, Drug Use
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators.
- Conditions
- Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
- Trial name
- NCT00249496
- Testing
- Contingency management, Employment Only
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder
Suvorexant and Cocaine
The research proposed here will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for cocaine, as well as other cocaine-associated maladaptive…
- Trial name
- NCT03937986
- Testing
- Suvorexant, Cocaine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- William Stoops
Cocaine Use Disorder
A Study to Evaluate EMB 001 in Subjects With Cocaine Use Disorder
EMB-001 is a combination of 2 drugs: the cortisol synthesis inhibitor, metyrapone (Metopirone®), and the benzodiazepine receptor agonist, oxazepam (original trade name Serax®; now marketed as oxazepam (generic) only).
- Trial name
- NCT04501874
- Testing
- EMB-001
- Where
- 4 sites in United States
- Volunteers
- 82 people
- Sponsor
- Embera NeuroTherapeutics, Inc.
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Cocaine Dependence, Cocaine Withdrawal
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
- Trial name
- NCT01171183
- Testing
- controlled release carvedilol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Cocaine Dependence, Methamphetamine Dependence
Smoking-Cessation and Stimulant Treatment (S-CAST)
The primary objective of this study is to evaluate the impact of substance-abuse treatment as usual plus smoking-cessation treatment (TAU+SCT), relative to substance-abuse treatment as usual (TAU), on drug-abuse outcomes.
- Conditions
- Cocaine Dependence, Methamphetamine Dependence, Nicotine Dependence
- Trial name
- S-CAST (NCT01077024)
- Testing
- Smoking-cessation treatment
- Where
- 12 sites in United States
- Volunteers
- 538 people
- Sponsor
- University of Cincinnati
Cocaine Abuse, Cocaine Dependence
Progesterone for Postpartum Cocaine Relapse
The investigators propose a placebo-controlled, randomized clinical trial that would enroll 50 postpartum women with a history of cocaine abuse or dependence to assess whether progesterone (100mgs twice daily) decreases…
- Trial name
- NCT01249274
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Cocaine Dependence
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Currently, no effective drug treatment exists for cocaine dependence. Glutamate levels are disrupted with long-term cocaine use.
- Trial name
- NAC (NCT00218491)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
The Effect of Brief Potent Glutamatergic Modulation on Cocaine Dependence
This project will evaluate the effect of a single sub-anesthetic dose of ketamine on the time to first cocaine use and abstinence rates in 60 treatment-seeking cocaine-dependent individuals receiving mindfulness-based relapse…
- Trial name
- NCT01535937
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Dependence
Brain Function and Structure in Cocaine Dependence
The purpose of this study is to examine the role of brain MRI findings in predicting treatment outcomes among individuals with cocaine dependence.
- Trial name
- NCT02080832
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Virginia Commonwealth University