Clinical trials: Cocaine Dependency
Cocaine Dependence, Depressive Symptoms
Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in combination with gabapentin. The purpose of this study is to examine whether the antidepressant sertraline alone or combined with gabapentin…
- Trial name
- NCT00654953
- Testing
- sertraline, gabapentin
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Arkansas
Cocaine Dependence
Complementary Combination Therapy for Cocaine Dependence
The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers.
- Trial name
- NCT02538744
- Testing
- Doxazosin, Modafinil, cocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
A Multi-Center Trial of Nepicastat for Cocaine Dependence
The objective of this study is to evaluate the safety and efficacy of Nepicastat in improving the number of subjects that achieve abstinence from cocaine and reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT01704196
- Testing
- Nepicastat
- Where
- 10 sites in United States
- Volunteers
- 179 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Clavulanic Acid for the Treatment of Cocaine Use Disorder
A dose escalation study to assess the efficacy and safety of Clavulanic Acid (CLAV) vs. placebo (PBO) for the treatment of cocaine use disorder (CUD)
- Trial name
- NCT05562349
- Testing
- Clavulanic Acid Only Product
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Temple University
Drug Dependence
Automatic Versus Evaluative Components of Cue Reactivity
Background: Relapse to drug abuse often happens in the presence of stimuli that are associated with previous drug use, also known as cues. Drug-taking behavior appears to be partly controlled by such cues.
- Trial name
- NCT01036126
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Heroin Abuse
Effect of Clonidine on Responses to Imagery Scripts
Background: Research has shown that clonidine, a drug originally prescribed to treat high blood pressure and some symptoms of opioid withdrawal, can help block stress-induced relapse to heroin and cocaine seeking in rats.
- Trial name
- NCT00318760
- Testing
- Clonidine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorders
A Novel Anti-Obesity Drug Combination as a Pharmacotherapy for Cocaine Dependence
The research proposed in this application will determine the initial efficacy, safety and tolerability of a novel drug combination, bupropion and naltrexone, as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT01739192
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Craig Rush
HIV, Opiate Dependence
Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment
This study will test whether contingency management (monetary vouchers contingent on abstinence from drugs) that reinforces one behavior (achieving abstinence from drugs) leads to improved outcomes in other related behaviors…
- Trial name
- Project FIRST (NCT01376570)
- Testing
- Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
- Where
- 3 sites in United States
- Volunteers
- 242 people
- Sponsor
- Albert Einstein College of Medicine
Dual Diagnosis, Cocaine Abuse
Abstinence-Linked Money Management Multisite
Randomized clinical trial comparing a money management-based intervention involving storage and management of client funds, substance abuse counseling, and risk reduction counseling to individualized drug counseling.
- Conditions
- Dual Diagnosis, Cocaine Abuse, Cocaine Dependence, Polysubstance Abuse
- Trial name
- NCT01327586
- Testing
- ATM, Individual Drug Counseling
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- Yale University
Cocaine Dependence, Opiate Dependence
Cocaine Withdrawal and Pharmacotherapy Response
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day)…
- Trial name
- Carvedilol (NCT00566969)
- Testing
- sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Yale University
Cocaine Dependence
Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence
The objective of this research is to identify the functional neural mechanisms (as assessed using fMRI) of short-term N-acetylcysteine (NAC) administration among methadone-maintained individuals with cocaine dependence.
- Trial name
- NCT02994875
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Pharmacological Modulation of Cocaine Effects - 1
The purpose of this study is to conduct human laboratory studies of possible cocaine interactions with various potential treatment medications.
- Trial name
- NCT00000201
- Testing
- Selegiline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Heroin Dependence
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users.
- Conditions
- Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00149669
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Opioid Dependence, Cocaine Dependence
Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants
The purpose of this study is to evaluate whether prednisolone lowers intensity and frequency of craving in heroin-addicted subjects undertaking a detoxification of cocaine and/or heroin.
- Trial name
- Goliath (NCT02935101)
- Testing
- Prednisolone
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Prof. Dominique de Quervain, MD
Cocaine Addiction, Cocaine Dependence
Brain Imaging Study of the Effects of Modafinil in Cocaine Addiction
-Context: Study objectives Primary: impact of modafinil versus placebo on DAT density modifications in the striatal and extra-striatal regions in cocaine dependent subjects hospitalised from D3 to D21.
- Trial name
- CAIMAN (NCT00701532)
- Testing
- Modafinil and PET (brain imaging)
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cocaine-Related Disorders
Effects of Phenytoin on Cocaine Use in Humans - 2
The purpose of this study is to determine the effects of phenytoin on the self-administration of smoked cocaine.
- Trial name
- NCT00000285
- Testing
- Phenytoin
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
This study will investigate a treatment strategy in which a computer-assisted behavioral intervention will be used to help individuals stop their use of cocaine.
- Trial name
- NCT01986075
- Testing
- Computer-assisted behavior therapy, Mixed-Amphetamine Salts- Extended Release (MAS-ER)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Selegiline in Outpatient Treatment for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and clinical safety of selegiline in the treatment of cocaine dependence and to assess neurotoxicity (Magnetic Resonance Imaging, MRI) post-hoc as a possible variable for…
- Trial name
- NCT00000336
- Testing
- Selegiline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Addiction, Cocaine Abuse
Pramipexole as a Treatment for Cocaine Dependence
The purposes of this study are as follows: 1. To assess the cardiovascular and subjective effects of cocaine during treatment with pramipexole and placebo. 2.
- Conditions
- Cocaine Addiction, Cocaine Abuse, Cocaine Dependence, Substance Abuse
- Trial name
- NCT01651377
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine