Clinical trials: Cocaine Dependency
Cocaine-Related Disorders, Cocaine Addiction
Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence
This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups.
- Conditions
- Cocaine-Related Disorders, Cocaine Addiction, Substance-Related Disorders
- Trial name
- NCT01984177
- Testing
- Corticotropin-Releasing Hormone
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Rebalancing the Serotonergic System in Cocaine Dependence
In the United States, 1.5 million people abuse cocaine leading to a host of negative health and economic consequences, yet no FDA approved treatment exists.
- Trial name
- NCT03266939
- Testing
- Lorcaserin
- Where
- United States
- Sponsor
- Mclean Hospital
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Selegiline in Outpatient Treatment for Cocaine Dependence - 1
The purpose of this study is to evaluate the efficacy and clinical safety of selegiline in the treatment of cocaine dependence and to assess neurotoxicity (Magnetic Resonance Imaging, MRI) post-hoc as a possible variable for…
- Trial name
- NCT00000336
- Testing
- Selegiline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
5HT2CR Balance in Brain Connectivity in Cocaine Dependence
This project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as compared to non-drug using controls.
- Trial name
- NCT03921151
- Testing
- Mirtazapine 15 MG Oral Tablet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Pilot Study of Lisdexamfetamine for Treatment of Cocaine Dependence
The purpose of this study is to evaluate ideal dose or lisdexamfetamine and tolerability, plus reduction in cocaine use and craving.
- Trial name
- NCT01490216
- Testing
- lisdexamfetamine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Cocaine Dependence
Cognitive Remediation for Cocaine Dependence
The purpose of this study is to evaluate treatments designed to improve cocaine treatment success by combining medications that target cocaine-related cognitive impairments.
- Trial name
- NCT01393457
- Testing
- levodopa/carbidopa, Ropinirole 2 mg/d, Ropinirole 4 mg/d
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Cocaine Addiction, Cocaine Dependence
Brain Imaging Study of the Effects of Modafinil in Cocaine Addiction
-Context: Study objectives Primary: impact of modafinil versus placebo on DAT density modifications in the striatal and extra-striatal regions in cocaine dependent subjects hospitalised from D3 to D21.
- Trial name
- CAIMAN (NCT00701532)
- Testing
- Modafinil and PET (brain imaging)
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cocaine Dependence, Cocaine Use Disorder
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
This study was an internal program effectiveness evaluation of the effects of a four-session weekly individualized cognitive therapy program (called the "Mind Freedom Plan" (MFP)) on substance use outcomes and substance abuse…
- Conditions
- Cocaine Dependence, Cocaine Use Disorder, Opiate Dependence, Opioid-use Disorder
- Trial name
- NCT03662529
- Testing
- Four-Session Mind Freedom Plan, Treatment as usual therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Dependence, Cocaine
A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study
The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neuropsychological evaluations apt to be…
- Trial name
- CRACK-ANT (NCT01025219)
- Testing
- Collect 10 ml of Saliva for DNA extraction
- Where
- France
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Dependence, Opioid Dependence
Pharmacogenetics of Disulfiram for Cocaine
Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment.
- Trial name
- Disulfiram (NCT00149630)
- Testing
- Disulfiram, Methadone, CBT
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Baylor College of Medicine
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Cocaine-Related Disorders
Risperidone for Treatment of Cocaine Dependence in Outpatients - 12
The purpose of this study is to evaluate pharmacological efficacy and clinical safety of risperidone in the treatment of cocaine and amphetamine dependence.
- Trial name
- NCT00000347
- Testing
- Risperidone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Opioid-Related Disorders
Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect.
- Trial name
- NCT00218608
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine-related Disorders
Prize Reinforcement Contingency Management for Cocaine Dependence: a 24-week Randomized Controlled Trial
The purpose of this study is to determine whether prize-based contingency management (prizeCM) combined with cognitive behavioral therapy (CBT) is more effective in the treatment of of cocaine-dependent patients compared to CBT…
- Trial name
- NCT00877435
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Basel, Switzerland
Alcohol Dependence, Cocaine Dependence
Novel Pharmacotherapy for Dual Dependence
The purpose of this study is to evaluate the effects of Topiramate and Cognitive Behavioral Therapy for the treatment of alcohol and cocaine dependence.
- Trial name
- NCT00448825
- Testing
- Topiramate + Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Bankole Johnson
Cocaine Use Disorder, Alcohol Use Disorder
PPARγ Agonist Treatment for Cocaine Dependence
The purpose of this research study is to determine whether a medication called pioglitazone (trade name Actos) can reduce behavioral problems associated with cocaine use, improve brain structural changes associated with cocaine…
- Trial name
- NCT02774343
- Testing
- Pioglitazone, Therapy, Contingency Management
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston