Clinical trials: Cocaine Dependency
Opioid Dependence, Cocaine Dependence
Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants
The purpose of this study is to evaluate whether prednisolone lowers intensity and frequency of craving in heroin-addicted subjects undertaking a detoxification of cocaine and/or heroin.
- Trial name
- Goliath (NCT02935101)
- Testing
- Prednisolone
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Prof. Dominique de Quervain, MD
Cocaine Abuse, Cocaine-Related Disorders
Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218075
- Testing
- Levodopa, Carbidopa, Clinical Management
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence, Cocaine Abuse
Modafinil - Escitalopram Study for Cocaine Dependence
The purpose of this study is to improve the efficacy of modafinil as a potential treatment for cocaine dependence.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01601730
- Testing
- Modafinil and Escitalopram, Modafinil, Escitalopram
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement
Cocaine use, abuse and dependence is a public health problem that is directly responsible for hundreds of billions of dollars in health care expenditures per year.
- Trial name
- NCT01143857
- Testing
- Varenicline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jennifer Plebani
Cocaine Addiction, Cocaine Abuse
Pramipexole as a Treatment for Cocaine Dependence
The purposes of this study are as follows: 1. To assess the cardiovascular and subjective effects of cocaine during treatment with pramipexole and placebo. 2.
- Conditions
- Cocaine Addiction, Cocaine Abuse, Cocaine Dependence, Substance Abuse
- Trial name
- NCT01651377
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Alcohol-Related Disorders, Cocaine-Related Disorders
Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4
The purpose of this study is to evaluate naltrexone as an adjunct in alcoholic cocaine dependent patients; concurrent relapse prevention theory.
- Trial name
- NCT00000307
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Complementary Combination Therapy for Cocaine Dependence
The investigators will assess the impact of treatment with doxazosin and modafinil, alone and in combination, on the subjective and reinforcing effects of cocaine in non-treatment-seeking, cocaine-dependent volunteers.
- Trial name
- NCT02538744
- Testing
- Doxazosin, Modafinil, cocaine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Baylor College of Medicine
Cocaine Use Disorder, Cocaine Dependence
TDCS for Cocaine Addiction Craving
Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation in which low level electrical currents are applied to the scalp in order to alter brain function.
- Trial name
- NCT03833583
- Testing
- Soterix Medical mini-CT tDCS stimulator
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Soterix Medical
Behavior, Addictive, Cocaine Abuse
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2
The purpose of this study is to determine whether long-term exposure to the Therapeutic Workplace intervention could sustain drug abstinence over an extended period of time in heroin- and cocaine-dependent, unemployed…
- Conditions
- Behavior, Addictive, Cocaine Abuse, Cocaine Dependence, Heroin Dependence
- Trial name
- NCT00249457
- Testing
- Contingency management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cocaine Addiction
Cognitive Enhancement and Relapse Prevention in Cocaine Addiction
For this project, the investigators are interested in exploring a new way to extend and maintain drug abstinence in people who are addicted to crack cocaine.
- Trial name
- NCT01067846
- Testing
- Seromycin (D-cycloserine, DCS), Computerized Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Arkansas
Alcohol-Related Disorders, Alcoholism
Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence
Modafinil is a medication that may enhance mood and increase energy in cocaine addicts, which may be useful in preventing cocaine relapse. Naltrexone is a medication that is currently used to treat drug and alcohol addiction.
- Conditions
- Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
- Trial name
- Mod-Nal (NCT00142818)
- Testing
- Naltrexone, Modafinil
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Kyle Kampman
Cocaine Dependence, Alcohol Dependence
10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence
The goal of this double-blind sham controlled study is to evaluate the effeicacy of continuous theta burst stimulation to the frontal pole as a tool to decrease drug cue reactivity and improve treatment outcomes in…
- Trial name
- NCT03238859
- Testing
- Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy and Intensive Treatment - 2
The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.
- Trial name
- NCT00000218
- Testing
- Carbamazepine
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence
The proposed protocol is an open-label pilot study of the treatment of cocaine dependence using lisdexamfetamine (LDX), a prodrug of d-amphetamine.
- Trial name
- Vyvance (NCT01486810)
- Testing
- Lisdexamfetamine, medication management
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Metabolic Effects of Cocaine
The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence
- Trial name
- NCT00451230
- Testing
- cocaine, hydrocortisone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence - 4
The purpose of this study is to empirically test a series of medications to: 1) determine each medication's efficacy in treatment of cocaine abuse/dependence; 2) find most effective dose range for each medication.
- Trial name
- NCT00000301
- Testing
- Amantadine
- Where
- United States
- Sponsor
- University of California, Los Angeles
Cocaine-Related Disorders
Ritanserin in Treatment of Cocaine Dependence - 1
The purpose of this study is to assess ritanserin as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000187
- Testing
- Ritanserin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000315
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Chantix for Treating Cocaine Dependence
The purpose of this study is to determine whether varenicline (Chantix), is effective for the treatment of cocaine dependence.
- Trial name
- NCT00567008
- Testing
- varenicline
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pennsylvania