Clinical trials: Cocaine Dependency
Cocaine Dependence
The Efficacy of Doxazosin for Cocaine Users
Doxazosin, an alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine dependent participants.
- Trial name
- NCT00880997
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependency
A Safety, Tolerability and Pharmacokinetic Study of CPP-115
Primary Objective: To evaluate the safety and tolerability of ascending single oral doses of CPP-115 Secondary Objective: To determine the pharmacokinetic profiles of CPP-115 following administration of a ascending single oral…
- Trial name
- NCT01493596
- Testing
- CPP-115
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Catalyst Pharmaceuticals, Inc.
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to determine whether patients with the greatest loss of dopamine transmission due to cocaine dependence at pre-treatment PET and MRI scans will be those who fail to respond to substance abuse…
- Trial name
- PET-CRA (NCT00376558)
- Testing
- Community Reinforcement Approach
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Opiate Dependence
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
The main goal of this study is to evaluate the safety and tolerability of 40 or 80 mg atomoxetine as a treatment for cocaine dependence.
- Trial name
- NCT01802515
- Testing
- Atomoxetine, low dose, Atomoxetine, high dose
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Cocaine Dependence
Clinical Trial of Topiramate for Cocaine Addiction
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment.
- Trial name
- NCT00685178
- Testing
- topiramate, Contingency Reinforcement
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts.
- Trial name
- NCT03471182
- Testing
- Psychiatric and Cognitive Testing, Cocaine Self-adminstration, Positron Emission Tomography
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Abuse and Dependence
Use of Donepezil for Treatment of Cocaine Dependence
The purpose of this study is to determine the safety of intravenous cocaine in subjects receiving oral donepezil.
- Trial name
- NCT00467389
- Testing
- Donepezil, 5 mg daily
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Cocaine Dependence
Therapeutic Cocaine Vaccine: Human Laboratory Study
Clinical data demonstrate that a cocaine vaccine (TA-CD: Celtic Pharmaceutical) produces selective anti-cocaine antibodies, yet the impact of these antibodies on cocaine's direct effects is unknown.
- Trial name
- NCT00965263
- Testing
- Cocaine vaccine (TA-CD)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Bipolar Disorder, Cocaine Dependence
Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency
The purpose of this study is to determine if lamotrigine add-on therapy is associated with decreased cocaine craving and improvement in depressive symptom severity than placebo in a group of outpatients with bipolar disorder and…
- Trial name
- NCT00280293
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
COCAINE-RELATED DISORDERS
Improving Learning-based Treatment of Cocaine Dependence With Medication
This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.
- Trial name
- NCT01526538
- Testing
- d-cycloserine, sugar pill
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder
Trial Of NS2359 For The Treatment of Cocaine Dependence
NS2359 attenuates the euphoria associated with cocaine use. In a manner parallel to cocaine, NS2359 blocks the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5HT) with nanomolar affinities at the 3 transporters.
- Trial name
- NCT02798627
- Testing
- NS2359
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Pharmacotherapy & CM for Opioid and Cocaine Dependence
The purpose of this study is to compare the efficacy of the combined treatment modafinil + Contingency Management (CM) to either treatment condition alone or to yoked-controls on cocaine abstinence.
- Trial name
- NCT00838981
- Testing
- Modafinil, Sugar Pill, Contingency Management
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Yale University
Cocaine Dependence
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
This is a residential pilot trial to evaluate the pharmacodynamic interaction between zonisamide and cocaine, with the goal of evaluating zonisamide's potential for the treatment of cocaine dependence.
- Trial name
- NCT01137890
- Testing
- Zonisamide, Cocaine Hydrochloride, Neurocognitive and Performance Battery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Alcohol-Related Disorders, Alcoholism
Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence
Modafinil is a medication that may enhance mood and increase energy in cocaine addicts, which may be useful in preventing cocaine relapse. Naltrexone is a medication that is currently used to treat drug and alcohol addiction.
- Conditions
- Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
- Trial name
- Mod-Nal (NCT00142818)
- Testing
- Naltrexone, Modafinil
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Kyle Kampman
Cocaine Dependence
Progesterone Treatment for Cocaine-dependent Women: A Pilot Study
The purpose of this pilot treatment trial is to evaluate the efficacy of oral micronized PROG in cocaine-dependent women. Since we have shown (Evans \& Foltin, 2006) that oral micronized PROG attenuates the positive subjective…
- Trial name
- PROG (NCT00632099)
- Testing
- Oral micronized progesterone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Multisite Controlled Trial of Cocaine Vaccine
The purpose of this study is to test the efficacy of a newly developed active vaccine against cocaine (TA-CD).
- Trial name
- TA-CD (NCT00969878)
- Testing
- TA-CD Vaccination
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Baylor College of Medicine
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Beta-blockade Effects on Memory for Cocaine Craving
The purpose of this study is to examine the effects of propranolol versus placebo on responses to cocaine cues in cocaine dependent individuals.
- Trial name
- NCT00830362
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina