Clinical trials: Cocaine Dependency
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000315
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Opioid Dependence
Pharmacogenetics of Disulfiram for Cocaine
Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment.
- Trial name
- Disulfiram (NCT00149630)
- Testing
- Disulfiram, Methadone, CBT
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence, Cocaine Addiction
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
The purpose of this study is to determine the safety and effects of rivastigmine and huperzine A (HupA), potential treatments for cocaine abuse, when used before experimental administration of cocaine, on a number of physical and…
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01030692
- Testing
- Rivastigmine 3 mg, Huperzine A 0.4 mg, Rivastigmine 6 mg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
Metabolic Effects of Cocaine
The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence
- Trial name
- NCT00451230
- Testing
- cocaine, hydrocortisone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance-Related Disorders
Methylphenidate for Cocaine Dependence
This phase II pilot study aims at evaluating the benefits and the risks of methylphenidate (Concerta®) for the treatment of cocaine/crack dependence in terms of cocaine/crack use reduction and adverse events.
- Trial name
- ANRS STIMAGO (NCT03090269)
- Testing
- Methylphenidate Pill
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Alcoholism, Cocaine Dependence
Topiramate for Alcohol and Cocaine Dependence
The primary purpose of this study is to test the effectiveness of topiramate for the treatment of combined alcohol and cocaine dependence. Topiramate is approved for the treatment of seizures.
- Trial name
- TOP2 (NCT00167245)
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Kyle Kampman
Cocaine-Related Disorders
Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1
The purpose of this study is to assess potential interactions between intravenous (i.v.) cocaine and atomoxetine (Strattera) administered orally in four escalating doses.
- Trial name
- NCT00265265
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Opioid Dependency
Disulfiram for Cocaine Abuse in Buprenorphine Treatment
The investigators are proposing a placebo-controlled clinical trial to evaluate the efficacy and potential mechanisms of action of disulfiram (versus placebo) for treating cocaine abuse in subjects with concurrent opiate…
- Trial name
- NCT00913484
- Testing
- Disulfiram
- Where
- 2 sites in United States
- Volunteers
- 177 people
- Sponsor
- Yale University
Cocaine Dependence
Clinical Trial of Topiramate for Cocaine Addiction
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment.
- Trial name
- NCT00685178
- Testing
- topiramate, Contingency Reinforcement
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Effects of Propranolol on Responses to Drug-Related Imagery Scripts
Background: Relapse to drug abuse is thought to result, in many cases, from exposure to cues that trigger drug-related memories or emotional associations for example, the association between the sight of a crack pipe and a set of…
- Trial name
- NCT00688805
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine-Related Disorders
Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218075
- Testing
- Levodopa, Carbidopa, Clinical Management
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The University of Texas Health Science Center, Houston
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cocaine Dependence
5HT2CR Balance in Brain Connectivity in Cocaine Dependence
This project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as compared to non-drug using controls.
- Trial name
- NCT03921151
- Testing
- Mirtazapine 15 MG Oral Tablet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Human Behavioral Pharmacology Laboratory Study of Varenicline's Impact on Cocaine Reinforcement
Cocaine use, abuse and dependence is a public health problem that is directly responsible for hundreds of billions of dollars in health care expenditures per year.
- Trial name
- NCT01143857
- Testing
- Varenicline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jennifer Plebani
Cocaine Related Disorders
The Effect of Yohimbine on Cocaine Cue Reactivity
Stress and cues reminiscent of cocaine use promote craving and relapse in cocaine dependent individuals. In addition, there appears to be gender differences in determinants of relapse to drug use following abstinence in…
- Trial name
- NCT00535002
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Use Disorder, Crack Abuse or Dependence
Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine and Crack Use Disorder
This is a single-center, randomized intervention study in a volunteer population of patients with cocaine/crack use disorder to evaluate the pharmacological treatment of cocaine/crack craving, comparing the drug clonidine with…
- Trial name
- NCT07313371
- Testing
- clonidine, clonazepam 0,25 mg
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine Use Disorder
Methylphenidate-Duloxetine Combinations for Cocaine Dependence
This study will determine the influence of methylphenidate (e.g., Ritalin®) and duloxetine (Cymbalta®), alone and in combination, on the cocaine use as measured by self-report and urine drug screens.
- Trial name
- NCT02700711
- Testing
- Methylphenidate, Duloxetine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Substance Abuse, Cocaine Dependence
Bupropion-Enhanced Contingency Management (CM) for Cocaine Dependence
This project will examine effects of bupropion extended release (XL) at a dose of 300mg/day for cocaine abstinence among persons receiving methadone for the treatment of opioid use disorder.
- Trial name
- NCT02111798
- Testing
- Bupropion XL, Abstinence Initiation, Relapse Prevention
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Modafinil, a medication that enhances mood, increases energy, and improves concentration, may be useful in preventing…
- Trial name
- NCT00218387
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Medical University of South Carolina
Cocaine Use Disorder, Cocaine Dependence
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder or opioid use disorder.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder
- Trial name
- NCT07318480
- Testing
- Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai