Clinical trials: Cocaine Dependency
Cocaine-Related Disorders, Opioid-Related Disorders
Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone
Cocaine is an extremely addictive stimulant drug that directly affects the brain. It is used in several different forms and can be snorted, smoked, or injected to achieve the desired effect.
- Trial name
- NCT00218608
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorder, Opiate Dependence
Clinical Efficacy of Disulfiram in LAAM-Maintained Cocaine Abusers
This 18-week, randomized, double blind clinical trial provided treatment for 160 cocaine-dependent opioid addicts, aged 18-65 years.
- Trial name
- NCT00580827
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Yale University
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence, Cocaine Abuse
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence
The purpose of this study is to determine the effects of treatment with cabergoline, compared to treatment with placebo, on cocaine induced craving and subjective effects in cocaine-dependent human volunteers.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01651364
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Ritanserin in Treatment of Cocaine Dependence - 1
The purpose of this study is to assess ritanserin as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT00000187
- Testing
- Ritanserin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Cocaine Abuse
ALK33BUP-101: Safety and Pharmacodynamic Effects of ALKS 33-BUP Administered Alone and When Co-administered With Cocaine
The purpose of this study is to assess the safety and tolerability of ALKS33-BUP when administered to opioid-experienced cocaine abusers.
- Trial name
- NCT01366001
- Testing
- ALKS 33-BUP, ALKS 33
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Alkermes, Inc.
Cocaine Dependence
Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence
In a randomized, double-blind controlled trial the investigators will evaluate the efficacy of rTMS in reducing impulsivity for cocaine addicts through - Quantitative and qualitative analysis - such behavior and possible…
- Trial name
- TMSCOCAINE (NCT01397266)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine Dependence
Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics
No medications are currently available for treatment of psychostimulant addiction, a compulsive preoccupation with use of cocaine and related compounds.
- Trial name
- NCT01406522
- Testing
- Oral tacrine
- Where
- United States
- Sponsor
- Midwest Biomedical Research
ADHD, Opioid-Related Disorders
Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
The purpose of this study is to treat Adult Attention Deficit Hyperactivity Disorder (ADHD) in methadone patients.
- Conditions
- ADHD, Opioid-Related Disorders, Cocaine Dependence
- Trial name
- NCT00061087
- Testing
- Methylphenidate, Bupropion
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Infusion Laboratory: Protocol 5 (Flupenthixol) - 14
The purpose of this study is to evaluate clinical safety issues pertaining to flupenthixol, to cocaine, and to their interaction, and to determine how pretreatment with flupenthixol modifies the subjective as well as…
- Trial name
- NCT00000349
- Testing
- Flupenthixol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Neural Systems, Drug Abuse
PET Assays of Striatal Dopamine Marker in Cocaine Craving
Background: Cues related to past drug use induce a particular pattern of brain activation, which has been correlated with craving for cocaine in active cocaine abusers.
- Conditions
- Neural Systems, Drug Abuse, Cocaine Dependence
- Trial name
- NCT01036516
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cocaine Addiction
Exercise as a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to test the effects of exercise on cocaine use, fitness, and cravings for cocaine and nicotine. This study is part of an effort to develop treatments for cocaine abuse.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01601743
- Testing
- Sitting, Running, Walking
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Cocaine Dependence, Depressive Disorder, Major
Integrated Treatment for Cocaine and Mood Disorders - 1
The purpose of this study is to test whether cognitive behavioral therapy and bupropion hydrochloride will help cocaine users, who are depressed, reduce or end their cocaine use and improve their mood.
- Trial name
- NCT00227812
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cannabis Dependence
Risk Perception in Drug-Dependent Adults With and Without Schizophrenia
Background: Several studies of risk perception have demonstrated a common bias known as unrealistic optimism, in which individuals feel they are less likely than other people to experience unpleasant or harmful events in their…
- Conditions
- Cocaine Dependence, Cannabis Dependence, Schizophrenia
- Trial name
- NCT01031563
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.
- Trial name
- NCT00100113
- Testing
- GBR 12909
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Venlafaxine to Reduce Cocaine Dependence in Depressed Individuals
Preliminary research has shown that venlafaxine, a medication currently used for treating depression, may also discourage cocaine use in depressed individuals.
- Trial name
- NCT00249483
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence
Treatment of Cocaine Dependence With Lisdexamfetamine
This protocol is a 2-group double-blind placebo-controlled outpatient study investigating lisdexamfetamine for treatment of cocaine dependence. The investigators plan to enroll 100 subjects in a 14-week trial.
- Trial name
- NCT00958282
- Testing
- lisdexamfetamine/Behavior Therapy
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota