Clinical trials: Cocaine Related Disorders
Addiction, Cocaine-Related Disorders
Benefits of Therapy With Virtual Reality Exposure in the Treatment of Cocaine Use Disorders
Cocaine addiction is a multifactorial disease with important consequences: somatic, psychiatric... The number of applications for treatment for cocaine addiction is gradually increasing from year to year but no conventional…
- Trial name
- CORVI (NCT04280900)
- Testing
- Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), Treatment as usual
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cocaine Dependence, Cocaine Addiction
Exercise as a Behavioral Treatment for Cocaine Dependence
The purpose of this study is to test the effects of exercise on cocaine use, fitness, and cravings for cocaine and nicotine. This study is part of an effort to develop treatments for cocaine abuse.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01601743
- Testing
- Sitting, Running, Walking
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
Pharmacologic MRI in Cocaine Addiction
In the proposed study, the investigators will assess the brain response to medication probes the investigators have previously studied with SPECT.
- Trial name
- phMRI (NCT01652378)
- Testing
- ondansetron, lidocaine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine-Related Disorders
High Dose Nimodipine Treatment Adjunct - 1
The purpose of this study is to determine if nimodipine is more effective than placebo in reducing stimulated craving for cocaine in cocaine dependent individuals denied access to cocaine in inpatient unit.
- Trial name
- NCT00000332
- Testing
- Nimodipine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine Dependence
Substance Abuse Pre-Treatment Screening Study
The overarching goal of this project is to have a consolidated consent and evaluation procedure that will lead potential subjects to the most appropriate clinical trial or human laboratory study (and its consent process) for…
- Conditions
- Cocaine Abuse, Cocaine Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00439049
- Testing
- modafinil, d-amphetamine, L-Dopa
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid-use Disorder, Cocaine Use Disorder
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use
- Trial name
- NCT04927143
- Testing
- App-Based Contingency Management
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wake Forest University Health Sciences
Cocaine Dependence
An fMRI Study of SYN115 in Cocaine Dependent Subjects
The dopamine system is critical in modulation of reward and has been implicated in the initiation and maintenance of addiction (Volkow et al 2004).
- Trial name
- NCT00783276
- Testing
- SYN115
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Virginia Commonwealth University
Cocaine-Related Disorders
Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.
- Trial name
- NCT00032929
- Testing
- Selegiline
- Where
- 16 sites in United States
- Volunteers
- 269 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Substance-Related Disorders
Nefazodone in the Treatment of Cocaine Dependence and Depression - 4
The purpose of this study is the use of Nefazodone in the treatment of cocaine dependence and depression comorbidity.
- Trial name
- NCT00015210
- Testing
- Nefazodone, Psychosocial Treatment
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Boston Medical Center
Cocaine Dependence
Study of the Effect of Magnetic Stimulation Repetitive Transcranial on Impulsivity in Cocaine Dependence
In a randomized, double-blind controlled trial the investigators will evaluate the efficacy of rTMS in reducing impulsivity for cocaine addicts through - Quantitative and qualitative analysis - such behavior and possible…
- Trial name
- TMSCOCAINE (NCT01397266)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine Addiction
Efficacy and Safety of TV-1380 as Treatment for Facilitation of Abstinence in Cocaine-Dependent Subjects
The primary objective of this study is to assess the efficacy and safety of TV-1380 [Recombinant human serum albumin (HSA) mutated butyrylcholinesterase (AlbuBChE)] in facilitating abstinence in cocaine-dependent subjects.
- Trial name
- NCT01887366
- Testing
- TV-1380 150 mg, TV-1380 300 mg
- Where
- 19 sites in United States, Spain
- Volunteers
- 208 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Cocaine-Related Disorders
Brain Mechanisms in Young Adults
The goal of this study is to use [C-11]NPA and amphetamine (oral, 0.5 mg/kg) to measure striatal dopamine transmission in prenatal cocaine exposed subjects (PCE) and comparison subjects (COMP)
- Trial name
- MHP (NCT03606473)
- Testing
- d-amphetamine, [C-11]NPA
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Gale Richardson
Cocaine-Related Disorders, Substance-Related Disorders
Early Phase II Trials for Cocaine Medication Development - 1
The purpose of this study is to develop models for early Phase II testing of potential medications for cocaine dependence: amoxapine, risperidone and other agents.
- Trial name
- NCT00000317
- Testing
- Risperidone, Relapse prevention counseling
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Cocaine Abuse
Long Term Maintenance of Drug Abstinence
The purpose of this study is to develop a model for long-term maintenance of behavior change by examining the effects of extending the duration of contingency management (CM) for drug abuse on long-term abstinence outcomes.
- Trial name
- NCT00842517
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Treatment Research Institute
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cocaine-Related Disorders
Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1
Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine drug-seeking behavior in formerly cocaine dependent rats.
- Trial name
- NCT00136825
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Infusion Laboratory: Protocol 3 (Risperidone) - 4
The purpose of this study is to evaluate clinical safety issues pertaining to risperidone, to cocaine and to its interaction, and to determine how pretreatment with risperidone modifies the subjective as well as physiological…
- Trial name
- NCT00000339
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Alterations in Serotonergic Functions in Cocaine Addicts - 1
The purpose of this study is to evaluate alterations in the serotonergic system in cocaine addicts and attempt to dissociate changes secondary to cocaine use from those associated with premorbid characteristics.
- Trial name
- NCT00000312
- Testing
- M-CPP
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Cocaine Abuse
A Pilot Study of Cabergoline for the Treatment of Cocaine Dependence
The purpose of this study is to determine the effects of treatment with cabergoline, compared to treatment with placebo, on cocaine induced craving and subjective effects in cocaine-dependent human volunteers.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Substance Abuse
- Trial name
- NCT01651364
- Testing
- Cabergoline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified placebo-controlled experimental design.
- Trial name
- NCT00015132
- Testing
- Sertraline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)