Clinical trials: Cocaine Related Disorders
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Substance Use Disorders
Longitudinal Assessment of Functional Connectivity in Treatment Engaged Cocaine Users
High-relapse rates to addiction are likely due to motivational (limbic) and cognitive (executive) factors. The purpose of this proposal is to determine the relationship between functional connectivity in executive control regions…
- Trial name
- NCT03554928
- Testing
- magnetic resonance imaging
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
The purpose of this study is to see if a drug called Candesartan will help to reduce use of cocaine.
- Trial name
- NCT01938664
- Testing
- Candesartan with CBT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 3
The purpose of this study is to evaluate the effects of buprenorpine on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate dependent cocaine users.
- Trial name
- NCT00000214
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Opioid Dependence, Opioid Related Disorders
A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abuse
This is a randomized, 4-sequence, 2-period, double-blind, placebo controlled study in male and female subjects with an American Psychiatric Association Diagnostic and Statistical Manual DSM-IV-TR diagnosis of cocaine abuse.
- Conditions
- Opioid Dependence, Opioid Related Disorders, Cocaine Dependence
- Trial name
- RBP-8000 (NCT01846481)
- Testing
- RBP-8000 100 mg, Cocaine, RBP-8000 200 mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indivior Inc.
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 1
The purpose of this study is to evaluate the effects of desipramine DMI maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving.
- Trial name
- NCT00000212
- Testing
- Desipramine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Drug Abuse, Cocaine Dependence
Brain Glutamate Receptors and Cocaine Dependence
Objective: Cocaine addiction continues to be an important public health problem with over 1.7 million users in the US alone. Cocaine addiction is characterized by compulsive drug use despite adverse consequences and high rates of…
- Trial name
- NCT00951314
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid
A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
- Trial name
- NCT04411914
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Temple University
Cocaine-Related Disorders, Substance-Related Disorders
Pathophysiological Subtyping of Abnormalities in Cocaine Dependence - 9
The purpose of this study is to define pathophysiological subtypes of abnormalities in subjects with cocaine dependence.
- Trial name
- NCT00015275
- Testing
- Cocaine-Related Disorders
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Serotonin, Impulsivity, and Cocaine Dependence Treatment
The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.
- Trial name
- NCT00297505
- Testing
- citalopram
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
The proposed protocol is a multi-site double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (MAS-ER) and topiramate in the treatment of cocaine dependence.
- Trial name
- TACT2 (NCT01811940)
- Testing
- Adderall-ER, Topiramate
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Dependence, Opiate Dependence
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
The main goal of this study is to evaluate the safety and tolerability of 40 or 80 mg atomoxetine as a treatment for cocaine dependence.
- Trial name
- NCT01802515
- Testing
- Atomoxetine, low dose, Atomoxetine, high dose
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Cocaine Related Disorders
Brain Imaging of Cocaine Craving in Recreational Cocaine Users
The purpose of this study is to compare individuals with cocaine dependence to recreational users of cocaine in terms of their brain reactivity to cocaine cues, in hopes that this comparison may help us better understand the…
- Trial name
- NCT01189578
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- James J. Prisciandaro
Cocaine-Related Disorders
Piracetam for Treatment of Cocaine Addiction, Phase II - 4
The purpose of this study is to follow patients in Phase I of an inpatient study in an eight week open label assessment of piracetam in an outpatient treatment program.
- Trial name
- NCT00000199
- Testing
- Piracetam
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Neurocircuit Strategy to Decrease Cocaine Cue Reactivity
The overarching goal of this project is to examine the effect of combining theta burst stimulation (TBS) and N-acetylcysteine (NAC) on cocaine craving and brain response to cocaine-related images.
- Trial name
- COCA (NCT04155632)
- Testing
- N-acetylcysteine, Theta-burst stimulation (TBS)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Bright Light Therapy During Inpatient Cocaine Detoxification
Cocaine is a major psychostimulant used to induce a state of euphoria, improved self-confidence and resistance to fatigue, with suppression of sleep.
- Trial name
- COKELUX (NCT07545798)
- Testing
- Medical light therapy device
- Where
- France
- Volunteers
- 256 people
- Sponsor
- Hôpital le Vinatier
Cocaine Dependence, Cocaine Addiction
A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction
Subjects will be randomly assigned to receive either one of the two potential dose combinations of the study medications or placebo over 6 weeks.
- Trial name
- NCT00567814
- Testing
- Metyrapone, Oxazepam
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Embera NeuroTherapeutics, Inc.
Cocaine Dependence, Cocaine-Related Disorders
Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance Patients
Background: The effectiveness of methadone maintenance for treatment of heroin addiction has been well established. However, patients maintained on methadone may relapse to cocaine use, even when they are enrolled in a…
- Conditions
- Cocaine Dependence, Cocaine-Related Disorders, Opioid-Related Disorders
- Trial name
- NCT00780702
- Testing
- Airipiprazole
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse
Dopamine Rhythms in Health and Addiction
Background: Dopamine is a chemical signal linked to the rewarding effects of drugs. Certain genes make these effects sensitive to the time of day they are taken. Cocaine can affect these genes in the brain.
- Trial name
- NCT02233829
- Testing
- Brain Dopamine Reactivity, Brain Dopamine Receptor
- Where
- United States
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Substance Abuse, Intravenous
The Long-Term Treatment of Drug Addiction and Unemployment
The purpose of this clinical trial is to evaluate the effectiveness and economic benefits of a Wage Supplement Model of arranging long-term exposure to employment-based abstinence reinforcement.
- Trial name
- NCT02487745
- Testing
- Abstinence-contingent wage supplements, Individual Placement and Support (IPS) supported employment
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Johns Hopkins University