Clinical trials: Cocaine Related Disorders
Stimulant Use Disorder
Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
The purpose of this study is to determine the effects of suvorexant (SUVO), on sleep, stress, and drug craving during early abstinence from stimulants and to determine the effects of treatment (SUVO vs.
- Trial name
- NCT06444256
- Testing
- SUVO, TAU
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders
Cocaine Abuse and ADHD - 10
The purpose of this study is to evaluate the safety and efficacy of buproprion in treating individuals with adult attention-deficit hyperactivity disorder (ADHD) and cocaine dependence.
- Trial name
- NCT00000275
- Testing
- Flupenthixol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cocaine-Related Disorders
Gepirone vs Placebo in Treatment of Cocaine Dependence - 3
The purpose of this study is to test antidepressant medication, gepirone, as a pharmacotherapy for cocaine dependent subjects.
- Trial name
- NCT00000189
- Testing
- Gepirone
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Measuring Distress Tolerance With Functional MRI
Background: People who are in treatment for substance abuse often feel distress during the withdrawal period and afterward. Some individuals feel distress more acutely than others, and this distress has been linked to poor…
- Trial name
- NCT01038232
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Addiction
Integration of the Therapeutic Workplace in Drug Court
Drug Courts were developed as a therapeutic alternative to incarceration of drug-involved offenders by providing 'judicially supervised' drug abuse treatment and probation for nonviolent offenders in lieu of criminal prosecution…
- Trial name
- NCT00607360
- Testing
- Therapeutic Workplace Intervention
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Effectiveness of N-Acetylcysteine (NAC) in Treating Cocaine Dependent Individuals - 1
Currently, no effective drug treatment exists for cocaine dependence. Glutamate levels are disrupted with long-term cocaine use.
- Trial name
- NAC (NCT00218491)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Medical University of South Carolina
Cocaine-Related Disorders
Aripiprazole to Reduce Cocaine Relapse
Despite the many behavioral and cognitive treatment therapies that exist for cocaine addiction, individuals who complete cocaine abuse treatment are still at high risk for relapsing.
- Trial name
- NCT00276874
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Craig Rush
Cocaine Abuse or Dependence, Cocaine Related Disorders
Effects of N-acetylcysteine on Brain Chemistry and Behavior in Cocaine Abusers (NAC)
N-acetylcysteine (NAC) is a medication that the Food and Drug Administration (FDA) has approved for several medical uses, such as dissolving mucus in patients with breathing problems, treating overdose from acetaminophen…
- Trial name
- NAC (NCT01392092)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine-Related Disorders
Piracetam for Treatment of Cocaine Addiction - 3
The purpose of this study is to evaluate the effects of IV cocaine administration in cocaine dependent subjects maintained on piracetam while they are residing in an inpatient addictions treatment research unit and to…
- Trial name
- NCT00000198
- Testing
- Piracetam
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Validation of a Remote Wireless Sensor Network (WSN) Approach to the Individualized Detection of Cocaine Use in Humans
This study looks to explore the feasibility, sensitivity, validity, and specificity of a Remote Wireless Sensor Network (RWSN) approach to the detection of cocaine use/intoxication in the inpatient human laboratory, as well as in…
- Trial name
- NCT02018263
- Testing
- Cocaine hydrochloride, Exercise, Nicotine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9
The purpose of this CREST (Clinical Rapid Evaluation Screening Trial) study is the use of tiagabine, sertraline, or donepezil for the treatment of cocaine dependence using a modified placebo-controlled experimental design.
- Trial name
- NCT00015132
- Testing
- Sertraline
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use, Opioid Use Disorder
Treating Polysubstance Use Using a Novel Digital Technology
The goal of this clinical trial is to determine the effects of an app to reduce opioid and cocaine use when layered atop methadone treatment as usual among people using both opioids and cocaine.
- Conditions
- Opioid Use, Opioid Use Disorder, Cocaine Use, Cocaine Use Disorder
- Trial name
- POLY (NCT05766631)
- Testing
- DynamiCare Health, Methadone Treatment-As-Usual
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- Friends Research Institute, Inc.
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy for Schizophrenic Drug Users - 6
The purpose of this study is to evaluate maintenance neuroleptics for Schizophrenic patients who are cocaine abusers.
- Conditions
- Cocaine-Related Disorders, Substance-Related Disorders, Shcizophrenia
- Trial name
- NCT00000281
- Testing
- Amantadine
- Where
- United States
- Sponsor
- Yale University
Cocaine-Related Disorders
Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10
The purpose of this study is to determine the effect of nefazodone on relapse to cocaine use in depressed and non-depressed females with cocaine abuse/dependence.
- Trial name
- NCT00000293
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000315
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Opioid Dependence
Pharmacogenetics of Disulfiram for Cocaine
Previous research has shown that disulfiram, a medication sometimes used for treating alcoholism, discourages cocaine use among cocaine addicts who are undergoing methadone treatment.
- Trial name
- Disulfiram (NCT00149630)
- Testing
- Disulfiram, Methadone, CBT
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Serotonin/Dopamine Antagonism of Cocaine Effect: 1 - 1
The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.
- Trial name
- NCT00000309
- Testing
- Risperidone
- Where
- United States
- Sponsor
- Butler Hospital
Cocaine Dependence, Cocaine Addiction
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
The purpose of this study is to determine the safety and effects of rivastigmine and huperzine A (HupA), potential treatments for cocaine abuse, when used before experimental administration of cocaine, on a number of physical and…
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01030692
- Testing
- Rivastigmine 3 mg, Huperzine A 0.4 mg, Rivastigmine 6 mg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
Metabolic Effects of Cocaine
The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence
- Trial name
- NCT00451230
- Testing
- cocaine, hydrocortisone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Drug Abuse (NIDA)