Clinical trials: Cocaine Related Disorders
Cocaine-Related Disorders
Towards Detecting Cocaine Use Using Smartwatches in the NIDA Clinical Trials Network
The overall objective of this study is to extend previous work in the development of methods to automatically detect the timing of cocaine use from cardiac interbeat interval and physical activity data derived from wearable…
- Trial name
- AutoSense (NCT02915341)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cocaine Dependence
First in Humans Study of JDTic
This is the first study to be conducted in humans for JDTic, a new chemical entity, with evaluations focusing on the safety, tolerability, and pharmacokinetics (PK) of JDTic following administration of single oral doses.
- Trial name
- NCT01431586
- Testing
- JDtic
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- RTI International
Cocaine-Related Disorders
Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3
The purpose of this study is to determine the effects of nefazedone on cocaine self-administration in depressed and non-depressed female cocaine users.
- Trial name
- NCT00000286
- Testing
- Nefazodone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder, Cocaine Dependence
Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder.
- Trial name
- Co-Boost (NCT06125054)
- Testing
- Ketamine, real-time fMRI neurofeedback training
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Marcus Herdener
Cocaine Dependence
Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-dependent Individuals
The purpose of this study is to assess the safety and preliminary efficacy of an anti-cocaine vaccine called dAd5GNE in cocaine-dependent individuals.
- Trial name
- NCT02455479
- Testing
- dAd5GNE Vaccine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Weill Medical College of Cornell University
Cocaine Dependence
Cocaine Use Disorder and Cortical Dopamine
The goal of this study is to use [C-11]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls
- Trial name
- NCT03349606
- Testing
- d-amphetamine, [C-11]FLB 457
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Substance Related Disorders, Drug Addiction
Contingency Management for Cocaine Dependence: Cash Versus Vouchers
Contingency management (CM) is a demonstrably efficacious intervention for substance abuse and dependence. Although CM protocols have employed a variety of reinforcers, they have almost exclusively relied upon non-cash privileges…
- Conditions
- Substance Related Disorders, Drug Addiction, Substance Abuse
- Trial name
- NCT01366716
- Testing
- Cash CM, Voucher CM
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- Treatment Research Institute
Cocaine-Related Disorders
Serotonin/Dopamine Antagonism of Cocaine Effect: 1 - 1
The purpose of this study is to evaluate use of risperidone with cocaine abusers. Study measures incorporate an appropriate integration of behavioral and neurobiological indices.
- Trial name
- NCT00000309
- Testing
- Risperidone
- Where
- United States
- Sponsor
- Butler Hospital
Cocaine Dependence
PET Imaging in Cocaine Self Administration
There has been recent interest in the role of the 5-HT1B receptor as a possible modulating factor in cocaine dependence, certainly in preclinical models.
- Trial name
- NCT02181491
- Testing
- [11C]-P943
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcoholism, Cocaine Dependence
Prazosin for ETOH or Cocaine Craving
This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-dependent and alcohol-dependent…
- Trial name
- NCT00240227
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- US Department of Veterans Affairs
Cocaine Addiction, Cocaine-related Disorder
Prefrontal Cortex Stimulation as Treatment for Crack-cocaine Addiction
The use of crack-cocaine is growing at alarming rate in our country and it is absolutely worrisome the fast establishment of addiction to it.
- Conditions
- Cocaine Addiction, Cocaine-related Disorder, Executive Dysfunction
- Trial name
- NCT01337297
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Espirito Santo
Cocaine Dependence
Impact of a Non-Drug Choice on Cocaine Reinforcement
Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for…
- Trial name
- NCT01906346
- Testing
- Cocaine
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cocaine-Related Disorders, Substance-Related Disorders
Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5
The purpose of this study is the use of Methylphenidate in the treatment of cocaine dependence and Attention Deficit Hyperactivity Disorder (ADHD) comorbidity.
- Trial name
- NCT00015223
- Testing
- Methylphenidate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder, Opioid Use Disorder
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine…
- Conditions
- Cocaine Use Disorder, Opioid Use Disorder, Stimulant Use Disorder
- Trial name
- BED IN 43 (NCT05610072)
- Testing
- n-acetylcysteine, Hydromorphone
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Cocaine Dependence
Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence
The purpose of this study is to examine the effects of the administration of Risperidal-Consta on the brain's reward circuitry using Magnetic resonance Imaging (MRI), behavioral tests and measuring cocaine craving and use among…
- Trial name
- NCT00385801
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cocaine Dependence
Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence
Trial to determine the safety, efficacy and tolerability of acamprosate for the treatment of cocaine dependence.
- Trial name
- CAMPRAL (NCT00385268)
- Testing
- acamprosate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Substance Use Disorder, Cocaine Use Disorder
Targeting Drug Memories With Methylphenidate
This study aims to identify the neural, behavioral, and pharmacological mechanisms promoting diminished expression of drug-related memories in human drug addiction.
- Trial name
- NCT05978167
- Testing
- Methylphenidate, Memory reconsolidation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine-Related Disorders
Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo
Dextro-amphetamine sulfate is a central nervous system stimulant that increases the release of the neurotransmitter dopamine in the brain.
- Trial name
- NCT00218348
- Testing
- Dextro-Amphetamine Sulfate
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders
Relapse Patterns in Female Cocaine Users - 4
The purpose of this study is to pilot a relapse questionnaire and examine relapse patterns in female cocaine users.
- Trial name
- NCT00000287
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Infusions, Intravenous
Cocaine-Metyrapone Interaction Study - 1
The purpose of this study is to examine the safety of two consecutive days of metyrapone (MRP) in subjects who may use cocaine concurrently.
- Trial name
- NCT00033098
- Testing
- Metyrapone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)