Clinical trials: Cocaine Withdrawal
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine Dependence, Opiate Dependence
Cocaine Withdrawal and Pharmacotherapy Response
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day)…
- Trial name
- Carvedilol (NCT00566969)
- Testing
- sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Yale University
Addiction, Opioid Dependence
Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid Addiction
The purpose of this study is determine the safety, efficacy and tolerability of a novel drug APH-1501 as a pharmacotherapy for Opioid Dependence. The investigators will evaluate the safety of escalating doses APH-1501.
- Conditions
- Addiction, Opioid Dependence, Opioid Withdrawal
- Trial name
- NCT03813095
- Testing
- APH-1501
- Volunteers
- 32 people
- Sponsor
- Aphios
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Substance Use Disorder, Cocaine Dependence
Cannabidiol and Cocaine Craving/Dependence
In this study, the investigators seek to evaluate the effects of cannabidiol (CBD) on cocaine craving and relapse. Cocaine addiction is characterized by compulsive substance use and repetitive urges to consume the drug even after…
- Conditions
- Substance Use Disorder, Cocaine Dependence, Withdrawal From Addictive Substance; Detoxification
- Trial name
- CBD (NCT02559167)
- Testing
- Cannabidiol
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cocaine Dependence, Cocaine Withdrawal
Carvedilol for Psychostimulant Dependence
This study examines whether carvedilol prolongs abstinence in recently abstinent cocaine dependent participants.
- Trial name
- NCT01171183
- Testing
- controlled release carvedilol
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Arkansas
Cocaine-Related Disorders, Substance Withdrawal Syndrome
Acute Withdrawal From Smoked Cocaine - 9
The purpose of this study is to develop an experimental paradigm to examine acute withdrawal symptoms from cocaine.
- Conditions
- Cocaine-Related Disorders, Substance Withdrawal Syndrome, Substance-Related Disorders
- Trial name
- NCT00000292
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder
Impact of Cocaine Use and Withdrawal on Sleep
This study investigates how cocaine use and withdrawal affect sleep and circadian rhythms in individuals undergoing inpatient detoxification.
- Trial name
- CokeSo (NCT07119567)
- Testing
- Multimodal Sleep and Biomarker Assessment
- Where
- 3 sites in France
- Volunteers
- 32 people
- Sponsor
- Hôpital le Vinatier
Cocaine-Related Disorders
Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Amantadine, a medication that improves muscle control, and propranolol, a medication that lowers blood pressure, may be…
- Trial name
- NCT00158132
- Testing
- Propranolol, Amantadine
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- University of Pennsylvania
Cocaine Withdrawal, Cocaine Smoking
Use of Intranasal Oxytocin During Detoxification of Crack Cocaine
This study investigated whether adding oxytocin nasal spray to usual inpatient treatment could reduce withdrawal, anxiety, and depressive symptoms in women hospitalized for cocaine detoxification.
- Conditions
- Cocaine Withdrawal, Cocaine Smoking, Cocaine-Related Disorders
- Trial name
- NCT04306354
- Testing
- Oxytocin nasal spray, Conventional Inpatient Treatment
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Cocaine Dependence
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
This is a residential pilot trial to evaluate the pharmacodynamic interaction between zonisamide and cocaine, with the goal of evaluating zonisamide's potential for the treatment of cocaine dependence.
- Trial name
- NCT01137890
- Testing
- Zonisamide, Cocaine Hydrochloride, Neurocognitive and Performance Battery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University