Clinical trials: Cocaine-Related Disorders
Cocaine-Related Disorders, Substance-Related Disorders
Pharmacotherapy and Intensive Treatment - 2
The purpose of this study is to evaluate desipramine and carbamazepine in reducing cocaine craving; increase outpatient treatment capacity and evaluate their incidence of psychiatric disorders.
- Trial name
- NCT00000218
- Testing
- Carbamazepine
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Neuropsychological Rehabilitation on Cocaine/Crack Dependents
Cocaine/Crack Dependence has been associated with neuropsychological impairments mainly in executive functions and decision-making, which are predominantly managed by the prefrontal cortex (PFC) in the brain.
- Trial name
- NCT01914835
- Testing
- Motivational Chess
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine Use Disorder
A Study to Investigate the Interaction Between TMP-301 and Cocaine.
This will be a randomized, double-blind, placebo-controlled, parallel-group study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of oral TMP-301, given concurrently with cocaine.
- Trial name
- NCT06648668
- Testing
- TMP-301
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Tempero Bio, Inc.
Alcohol Dependence, Cocaine Dependence
Combined Treatment for Cocaine-Alcohol Dependence - 1
The purpose of this study is to examine whether Naltrexone and cognitive behavioral therapy can be helpful in patients who want to stop using cocaine and alcohol.
- Trial name
- NCT00218569
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cocaine-Related Disorders
Cocaethylene as a Treatment for Cocaine Dependence - 1
Cocaine has been cited as the primary drug threat in the United States. The purpose of this study is to determine if cocaethylene, used as a prototype drug, is a safe and effective treatment for cocaine dependence.
- Trial name
- NCT00124696
- Testing
- Cocaethylene
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Drug Administration Schedule
Ondansetron for the Treatment of Cocaine Dependence - 1
The purpose of this study is to assess the efficacy and safety of ondansetron to reduce cocaine use in subjects with cocaine dependence.
- Trial name
- NCT00033085
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Related Disorders
Contingency Management Treatment for Crack Addiction - Study With Brazilian Population
Crack addiction has become a severe health problem in Brazil. Today, crack addiction is the primary cause for inpatient treatment for all illicit substances.
- Trial name
- NCT01815645
- Testing
- ST+CM, standard treatment
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Federal University of São Paulo
Cocaine-Related Disorders
Pemoline for Cocaine Abuse - 7
The purpose of this study is to evaluate the treatment of pemoline for cocaine abuse.
- Trial name
- NCT00000282
- Testing
- Pemoline
- Where
- United States
- Sponsor
- Yale University
Cocaine-Related Disorders
Effects of Labetalol on Human Cocaine Use - 8
The purpose of this study is to determine the effect of labetalol treatment on the subjective and physiological effects of cocaine.
- Trial name
- NCT00000291
- Testing
- Labetalol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Cocaine-Related Disorders
Pemoline in the Treatment of Stimulant Dependence - 5
The purpose of this study is to assess the efficacy of pemoline in treating cocaine and/or methamphetamine dependent adults with comorbid Adult Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT00000340
- Testing
- Pemoline
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer program.
- Trial name
- NCT00809835
- Testing
- Galantamine, Computer Assisted Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2
The purpose of this study is to determine the density of DA transporters during prolonged cocaine abuse and during withdrawal from cocaine use.
- Trial name
- NCT00000316
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Cocaine Use Disorder
Cariprazine for Comorbid Cocaine and Opioid Use Disorder
This is a phase IIa, randomized, placebo-controlled pilot study designed to examine whether low-dose cariprazine (1.5mg/d) impacts cocaine use in medically-stable OUD patients with co-occurring CocUD who have already been taking…
- Trial name
- NCT05063201
- Testing
- Cariprazine 1.5 MG
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kyle Kampman
Cocaine Dependence
D-Serine for Cocaine Dependence Pilot
The primary objective of this study is to collect pilot data on the efficacy of D-serine, relative to placebo, as a cocaine dependence treatment. Secondary objectives include evaluating D-serine, relative to placebo, on: 1.
- Trial name
- STED-CD (NCT01715051)
- Testing
- D-serine, Cognitive Behavioral Therapy
- Where
- United States
- Sponsor
- Theresa Winhusen
Substance-Related Disorders
Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use Disorder
This is a randomized, double-blind, placebo-controlled phase 2b pilot clinical trial to determine whether non-ergoline D3/D2/D1 dopamine (DA) receptor agonist rotigotine (RTG), in combination with treatment as usual, including…
- Trial name
- NCT05886582
- Testing
- Rotigotine Transdermal System [Neupro]
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina