Clinical trials: Cocaine-Related Disorders
Cocaine Dependence
Vigabatrin for Treatment of Cocaine Dependence
The objective of this study is to demonstrate that a larger proportion of vigabatrin-treated subjects than placebo-treated subjects will be cocaine-free in the last 2 weeks of treatment.
- Trial name
- NCT00611130
- Testing
- vigabatrin
- Where
- 11 sites in United States
- Volunteers
- 186 people
- Sponsor
- Catalyst Pharmaceuticals, Inc.
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
Carbidopa/Levodopa Combined With Behavioral Therapy for the Treatment of Cocaine Dependence
Cocaine dependence is a major public health problem and the development of a treatment for this disorder is a priority. To date, treatment interventions based on positive incentive principles have shown the strongest effects for…
- Trial name
- NCT00713583
- Testing
- levodopa, Cognitive Behavioral Therapy, Contingency Management
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
The Efficacy of Doxazosin for Cocaine Users
Doxazosin, an alpha 1-adrenergic receptor, may play an important role in cocaine addiction in humans. This study will evaluate the effectiveness of doxazosin in preventing drug relapse among cocaine dependent participants.
- Trial name
- NCT00880997
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Baylor College of Medicine
Cocaine Abuse, Opiate Dependence
Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
The purpose of this study is to examine two medications, modafinil and citalopram, in the treatment of cocaine dependent individuals who are maintained on methadone.
- Trial name
- NCT00218036
- Testing
- Modafinil 200mg, Modafinil 400mg, Citalopram 20mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Pilot Trial of Acamprosate for the Treatment of Cocaine Dependence
Trial to determine the safety, efficacy and tolerability of acamprosate for the treatment of cocaine dependence.
- Trial name
- CAMPRAL (NCT00385268)
- Testing
- acamprosate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cocaine Dependence
A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
The purpose of this study is to see if a drug called Candesartan will help to reduce use of cocaine.
- Trial name
- NCT01938664
- Testing
- Candesartan with CBT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Cocaine Abuse, Cocaine Dependence
n-Acetylcysteine and Cocaine
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine as a pharmacotherapy for cocaine dependence.
- Trial name
- NCT02141620
- Testing
- Cocaine, n-Acetylcysteine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Cocaine Dependence
Effectiveness of Extended Treatments for Drug Dependence
This study tests the effectiveness of two 24 month, telephone-based adaptive continuing care interventions for patients with cocaine dependence.
- Trial name
- ETDD (NCT00685659)
- Testing
- Intensive Outpatient Treatment, Adaptive telephone-based counseling, Adaptive telephone-based counseling plus incentives
- Where
- 2 sites in United States
- Volunteers
- 332 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders, Heroin Dependence
Employment-based Reinforcement of Naltrexone Ingestion and Abstinence
A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting naltrexone ingestion and abstinence in unemployed opiate-dependent injection drug users.
- Conditions
- Cocaine-Related Disorders, Heroin Dependence, Opioid-Related Disorders, Substance Abuse, Intravenous
- Trial name
- NCT00149669
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Cocaine Related Disorders
The Effect of Yohimbine on Cocaine Cue Reactivity
Stress and cues reminiscent of cocaine use promote craving and relapse in cocaine dependent individuals. In addition, there appears to be gender differences in determinants of relapse to drug use following abstinence in…
- Trial name
- NCT00535002
- Testing
- Yohimbine
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid
A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
- Trial name
- NCT04411914
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Temple University
Cocaine Dependence, Cocaine Abuse
Quetiapine for the Reduction of Cocaine Use
This placebo-controlled trial will test the effectiveness of Seroquel XR™ for the treatment of cocaine dependence in non-psychotic individuals who are cocaine dependent.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Drug Abuse
- Trial name
- AZC (NCT00631748)
- Testing
- quetiapine fumarate, Cognitive-behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Bipolar Disorder, Cocaine Dependence
Lamotrigine add-on Therapy for Bipolar Disorder and Cocaine Dependency
The purpose of this study is to determine if lamotrigine add-on therapy is associated with decreased cocaine craving and improvement in depressive symptom severity than placebo in a group of outpatients with bipolar disorder and…
- Trial name
- NCT00280293
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Texas Southwestern Medical Center
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Substance Use Disorders
Adaptive Treatment for Alcohol and Cocaine Dependence
1. Primary objective #1: Determine the relative effectiveness of MI-IOP and MI-PC in the full study sample with regard to treatment engagement over weeks 1-12 and cocaine/alcohol use over weeks 1-24.
- Trial name
- NCT01032135
- Testing
- Motivational Interviewing, Telephone counseling, Cognitive Behavioral Therapy (CBT) Counseling
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Pennsylvania