Clinical trials: Cocaine-Related Disorders, open to volunteers
Visual Snow Syndrome, Color Blindness
Study of Visual Perception Phenomena: Phosphene Mapping Induced by TMS and Its Relationship With Eye Movements
The purpose of this basic science study is to better understand human visual perception. Phosphenes are flashes of light that can be induced using Transcranial Magnetic Stimulation (TMS).
- Conditions
- Visual Snow Syndrome, Color Blindness, Healthy Volunteer
- Trial name
- NCT07110493
- Testing
- Transcranial Magnetic Stimulation (TMS), Electroencephalography (EEG), Eye-Tracking
- Where
- Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Cocaine Use Disorder, Cocaine Dependence
Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction
The goal of this clinical trial is to learn about the effects of the combination of ketamine and realtime functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder.
- Trial name
- Co-Boost (NCT06125054)
- Testing
- Ketamine, real-time fMRI neurofeedback training
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Dr. med. Marcus Herdener
Stimulant Use Disorder
Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
The purpose of this study is to determine the effects of suvorexant (SUVO), on sleep, stress, and drug craving during early abstinence from stimulants and to determine the effects of treatment (SUVO vs.
- Trial name
- NCT06444256
- Testing
- SUVO, TAU
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Safety Study of a Disrupted Adenovirus (Ad) Serotype Cocaine Vaccine for Cocaine-dependent Individuals
The purpose of this study is to assess the safety and preliminary efficacy of an anti-cocaine vaccine called dAd5GNE in cocaine-dependent individuals.
- Trial name
- NCT02455479
- Testing
- dAd5GNE Vaccine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Weill Medical College of Cornell University
Stimulant Use Disorder
Smartphone Services for Stimulant Use Disorder
This study is testing two approaches to treating Stimulant Use Disorder, or problems with cocaine, crack, methamphetamine, etc. Stimulant Use Disorder is a national epidemic in the U.S.
- Trial name
- NCT07092059
- Testing
- Smartphone digital therapeutic system
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- DynamiCare Health
Cocaine Dependence
Effect of HF rTMS on Serum BDNF in Cocaine Use Disorder
This study aims to explore the effect of 5-Hz rTMS over the left dorsolateral prefrontal cortex on the BDNF, craving and cognitive function.
- Trial name
- NCT06189690
- Testing
- rTMS
- Where
- Mexico
- Volunteers
- 102 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine Use Disorder, Cocaine Dependence
Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder
The researchers will test whether cognitively enhanced transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex can reduce craving in inpatients with cocaine use disorder or opioid use disorder.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder
- Trial name
- NCT07318480
- Testing
- Transcranial Direct Current Stimulator (tDCS), Cognitive Reappraisal Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine Use Disorder
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder
The purpose of this study is to evaluate semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in combination with cognitive behavioral therapy (CBT) for the treatment of cocaine use disorder (CUD).
- Trial name
- NCT07227948
- Testing
- Semaglutide, cognitive behavioral therapy (CBT).
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Use Disorder (AUD), Alcoholism
Role of Pavlovian Mechanisms for Control Over Substance Use
During the first funding period (1st FP), the investigators developed a novel full Pavlovian-to-instrumental transfer (PIT) task that allows assessing both, general and specific PIT to investigate whether specific PIT differs…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Cannabis Use Disorder
- Trial name
- ReCoDe (NCT06701487)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Pavlovian-to-instrumental transfer (PIT) paradigm
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Technische Universität Dresden
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern
Drug Use, Substance Abuse
Harm Reduction Services
The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve harm reduction service utilization among Black and Latinx people who…
- Conditions
- Drug Use, Substance Abuse, Mental Illness
- Trial name
- HRS (NCT05776316)
- Testing
- Integrated Harm Reduction Intervention (IHRI)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Substance Use Disorder, Alcohol Use Disorder
Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP
Background: People who will participate in research studies need to undergo proper screening, evaluation, and assessment (SEA). SEA helps keep those who participate in studies safe. It also helps ensure accurate study results.
- Trial name
- NCT06552741
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder
The purpose of this study is to assess effects of intermittent theta burst stimulation (iTBS) to left dorsolateral prefrontal cortex (dlPFC) and dorsomedial prefrontal cortex (dmPFC) compared to sham on electrophysiological…
- Trial name
- NCT05986578
- Testing
- TMS to dmPFC, TMS to dlPFC
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The University of Texas Health Science Center, Houston
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Cocaine Use Disorder
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive…
- Trial name
- NCT05529927
- Testing
- Sustained-release Dexamphetamine
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Parnassia Addiction Research Centre
Cocaine-Related Disorders
Bright Light Therapy During Inpatient Cocaine Detoxification
Cocaine is a major psychostimulant used to induce a state of euphoria, improved self-confidence and resistance to fatigue, with suppression of sleep.
- Trial name
- COKELUX (NCT07545798)
- Testing
- Medical light therapy device
- Where
- France
- Volunteers
- 256 people
- Sponsor
- Hôpital le Vinatier