Clinical trials: Cocaine-related Disorders
Cocaine Addiction
Dexamphetamine Sustained Release Pharmacokinetics and Clinical Validation of Dried Blood Spots
The pharmacokinetics of 10 to 12 individuals receiving 60 mg of sustained release dexamphetamine will be studied. These individuals have received this medication before in a previous trial where the pharmacodynamics were…
- Trial name
- NCT02768441
- Testing
- Dexamphetamine
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Cocaine Dependence
A Multi-Center Trial of Nepicastat for Cocaine Dependence
The objective of this study is to evaluate the safety and efficacy of Nepicastat in improving the number of subjects that achieve abstinence from cocaine and reducing cocaine use in subjects with cocaine dependence.
- Trial name
- NCT01704196
- Testing
- Nepicastat
- Where
- 10 sites in United States
- Volunteers
- 179 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Effects of Phenytoin on Cocaine Use in Humans - 2
The purpose of this study is to determine the effects of phenytoin on the self-administration of smoked cocaine.
- Trial name
- NCT00000285
- Testing
- Phenytoin
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use, Cocaine Intoxication
Comparing Efficacy & Safety Of TNX-1300 To Placebo With UC For Treatment Of Acute Cocaine Intoxication In ED Subjects (CATALYST)
This is a Phase 2 single-blind, randomized, multicenter study to compare the efficacy and safety of a single dose of TNX-1300 to placebo with usual care in patients with acute cocaine intoxication within the emergency department…
- Conditions
- Cocaine Use, Cocaine Intoxication, Cocaine Toxicity, Cocaine Abuse
- Trial name
- CATALYST (NCT06045793)
- Testing
- TNX-1300 (Injection)
- Where
- 6 sites in United States
- Volunteers
- 3 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Cocaine-Related Disorders
Modafinil Treatment for Cocaine-Dependent Individuals
Despite years of active research, there are still no approved medications for the treatment of cocaine dependence. The purpose of this study is to determine the effectiveness of modafinil in treating cocaine-dependent individuals.
- Trial name
- NCT00129285
- Testing
- Low Dose Modafinil, High Dose Modafinil
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Pennsylvania
Cocaine-Related Disorders
Topiramate to Reduce Cocaine Dependence
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Topiramate, a medication which lowers dopamine levels, may have the ability to diminish cocaine cravings in addicts.
- Trial name
- NCT00223626
- Testing
- Topiramate
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Bankole Johnson
Cocaine-Related Disorders
Dextroamphetamine-Cocaine Behavioral Intervention - 5
The purpose of this study is to examine dextroamphetamine-cocaine behavioral intervention in cocaine dependent patients.
- Trial name
- NCT00000308
- Testing
- Dextroamphetamine, D-amphetamine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders, Opioid-Related Disorders
Combined Buprenorphine and Behavioral Treatment With and Without Contingent Reinforcement on Opioid and Cocaine Abstinence. - 22
The purpose of this study is to test combined buprenorphine and behavioral treatment with and without contingent reinforcement on opioid and cocaine abstinence.
- Trial name
- NCT00000240
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- University of Vermont
Cocaine-Related Disorders
Cocaine Abuse and Attention Deficit Disorder - 3
The purpose of this study is to evaluate cocaine abuse and Attention Deficit Disorder
- Trial name
- NCT00000268
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Cocaethylene as a Treatment for Cocaine Dependence - 1
Cocaine has been cited as the primary drug threat in the United States. The purpose of this study is to determine if cocaethylene, used as a prototype drug, is a safe and effective treatment for cocaine dependence.
- Trial name
- NCT00124696
- Testing
- Cocaethylene
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-use Disorder, Cocaine Use Disorder
Feasibility and Validation of a Standard Phenotyping Assessment Battery
The overall goal of this project is to collect preliminary data on psychosocial measures and behavioral performance comparing individuals with Opioid Use Disorder, Cocaine Use Disorder, dual diagnosis of Opioid and Cocaine Use…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Marijuana Use Disorder, Healthy Controls
- Trial name
- PhAB (NCT03495869)
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- Virginia Commonwealth University
Cocaine Dependence
New Medication Treatment for Stimulant Dependence
This study will evaluate the efficacy of ondansetron compared with placebo in the treatment of cocaine dependence.
- Trial name
- NCT00689572
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Behavior, Addictive
The Effectiveness of a Brief Motivational Nursing Intervention
This was a two-staged study undertaken in entertainment-sector workers in Spain: the first part was transversal and observational, and the second was semi-experimental.
- Trial name
- BMNI (NCT04125303)
- Testing
- brief motivational psychoeducational therapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Cardenal Herrera University
Cocaine Related Disorders
Interactions Between Intravenous (IV) Cocaine and Lofexidine
The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and treatment with lofexidine.
- Trial name
- NCT01148992
- Testing
- Lofexidine
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
ADHD, Opioid-Related Disorders
Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
The purpose of this study is to treat Adult Attention Deficit Hyperactivity Disorder (ADHD) in methadone patients.
- Conditions
- ADHD, Opioid-Related Disorders, Cocaine Dependence
- Trial name
- NCT00061087
- Testing
- Methylphenidate, Bupropion
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- New York State Psychiatric Institute
Opioid-use Disorder, Cocaine Use Disorder
Cariprazine for Comorbid Cocaine and Opioid Use Disorder
This is a phase IIa, randomized, placebo-controlled pilot study designed to examine whether low-dose cariprazine (1.5mg/d) impacts cocaine use in medically-stable OUD patients with co-occurring CocUD who have already been taking…
- Trial name
- NCT05063201
- Testing
- Cariprazine 1.5 MG
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kyle Kampman
Cocaine-Related Disorders, Substance-Related Disorders
New Approaches to Cocaine Abuse Medications (A) - 6
The purpose of this study is to measure the effect of desipramine in cocaine abusers selected for major depression or dysthymia.
- Trial name
- NCT00000271
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- New York State Psychiatric Institute
Alcohol-Related Disorders, Alcoholism
Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1
Many cocaine dependent individuals are also dependent on alcohol. Such individuals respond poorly to existing treatments and have received little research attention in the past.
- Conditions
- Alcohol-Related Disorders, Alcoholism, Cocaine-Related Disorders
- Trial name
- NCT00142844
- Testing
- Naltrexone, Disulfiram
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence, Alcohol Dependence
10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence
The goal of this double-blind sham controlled study is to evaluate the effeicacy of continuous theta burst stimulation to the frontal pole as a tool to decrease drug cue reactivity and improve treatment outcomes in…
- Trial name
- NCT03238859
- Testing
- Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Medical University of South Carolina
Drug Addiction
Integration of the Therapeutic Workplace in Drug Court
Drug Courts were developed as a therapeutic alternative to incarceration of drug-involved offenders by providing 'judicially supervised' drug abuse treatment and probation for nonviolent offenders in lieu of criminal prosecution…
- Trial name
- NCT00607360
- Testing
- Therapeutic Workplace Intervention
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)