Clinical trials: Cocaine-related Disorders
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Cocaine-Related Disorders
Propranolol for Treatment of Cocaine Addiction - 2
The purpose of this study is to evaluate the safety and efficacy of propanolol in the early treatment of cocaine dependence.
- Trial name
- NCT00000197
- Testing
- Propranolol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse or Dependence, Cocaine Related Disorders
Non-Treatment Study of Factors Affecting Cocaine Drug Choice
This research deals with behaviors that are part of drug dependence. The purpose is to study how certain factors, including money, the amount of drug available, and the amount of work effort, affect cocaine drug choice.
- Trial name
- CTA (NCT00946660)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine Dependence
A Study of Baclofen ER
This is a Phase II, randomized, double-blind, placebo-controlled study that will examine the efficacy of extended-release baclofen (Baclofen ER) for the treatment of cocaine dependence.
- Trial name
- CURE (NCT02003664)
- Testing
- Baclofen ER
- Where
- United States
- Sponsor
- University of Pennsylvania
Cocaine Addiction, Opioid Addiction
sTMS for Substance Use-disordered Veterans
The purpose of this study is to determine if synchronized transcranial magnetic stimulation is safe and tolerable in individuals with cocaine, opioid, or alcohol use disorders.
- Conditions
- Cocaine Addiction, Opioid Addiction, Alcohol Addiction
- Trial name
- NCT04336293
- Testing
- sTMS
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Cocaine Dependence
Caffeine and Cocaine
This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse.
- Trial name
- NCT00733993
- Testing
- Caffeine 150 MG, Amphetamine, Caffeine 300 MG
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Drug Use, Substance Abuse
Harm Reduction Services
The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve harm reduction service utilization among Black and Latinx people who…
- Conditions
- Drug Use, Substance Abuse, Mental Illness
- Trial name
- HRS (NCT05776316)
- Testing
- Integrated Harm Reduction Intervention (IHRI)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Cocaine-Related Disorders
Infusion Laboratory: Protocol 3 (Risperidone) - 4
The purpose of this study is to evaluate clinical safety issues pertaining to risperidone, to cocaine and to its interaction, and to determine how pretreatment with risperidone modifies the subjective as well as physiological…
- Trial name
- NCT00000339
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Abuse
CBT With Disulfiram and Contingency Management
This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).
- Trial name
- NCT00350870
- Testing
- disulfiram, Disulfiram plus Contingency Management
- Where
- United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcoholism, Cocaine Dependence
Prazosin for ETOH or Cocaine Craving
This double-blind placebo controlled crossover pilot trial will test the hypothesis that prazosin, an alpha-1 adrenergic receptor antagonist, reduces craving for their drug of choice in cocaine-dependent and alcohol-dependent…
- Trial name
- NCT00240227
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- US Department of Veterans Affairs
Cocaine Dependence
Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET
Studies using positron emission tomography (PET) have been used with great success in demonstrating specific abnormalities in several facets of dopaminergic system function in human populations (Narendran and Martinez 2009).
- Trial name
- NCT02152670
- Testing
- Methylphenidate, Alpha Methyl Para Tyrosine (AMPT), [11C]PHNO
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Addiction
Comparing Acute and Continuous Drug Abuse Treatment: A Randomized Clinical Trial
The purpose of this 2 year study is to conduct a fully powered effectiveness trial comparing recovery trajectories of 200 drug dependent adults (the subjects) who will be randomly assigned to Treatment as Usual (TAU) or TAU +…
- Trial name
- NCT01003496
- Testing
- Treatment as Usual (TAU), TAU + Long-Term Recovery Management
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Wright State University
Cocaine Dependence, Opiate Dependence
Cocaine Withdrawal and Pharmacotherapy Response
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day)…
- Trial name
- Carvedilol (NCT00566969)
- Testing
- sugar pill, Carvedilol 25 mg, Carvedilol 50 mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Yale University
Cocaine Dependence
Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
The aim of this study is to assess the efficacy of caffeine compared to placebo as a maintenance treatment for cocaine dependence. Caffeine potentiation with biperiden will be also studied.
- Trial name
- NCT00495183
- Testing
- caffeine, Biperiden
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cocaine Dependence
Study of Buspirone for Relapse-Prevention in Adults With Cocaine Dependence
The purpose of this study is to evaluate whether or not buspirone is effective in preventing relapse in cocaine-dependent adults in inpatient/residential treatment who are planning to enter outpatient treatment upon…
- Trial name
- BRAC (NCT01641159)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati
Cocaine Use Disorder, Opioid Use Disorder
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine…
- Conditions
- Cocaine Use Disorder, Opioid Use Disorder, Stimulant Use Disorder
- Trial name
- BED IN 43 (NCT05610072)
- Testing
- n-acetylcysteine, Hydromorphone
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Heroin Dependence, Opioid-Related Disorders
Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals
The purpose of this study is to determine whether maintenance on different oral doses of sustained release d-amphetamine (SR-AMP) combined with constant-dose sublingual buprenorphine (BUP) is safe and well tolerated and decreases…
- Conditions
- Heroin Dependence, Opioid-Related Disorders, Cocaine Abuse or Dependence
- Trial name
- NCT00429767
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wayne State University
Cocaine-Related Disorders, Substance Withdrawal Syndrome
Acute Withdrawal From Smoked Cocaine - 9
The purpose of this study is to develop an experimental paradigm to examine acute withdrawal symptoms from cocaine.
- Conditions
- Cocaine-Related Disorders, Substance Withdrawal Syndrome, Substance-Related Disorders
- Trial name
- NCT00000292
- Testing
- Cocaine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Infusion Laboratory: Protocol 2 (Lisuride) - 3
The purpose of this study is to evaluate clinical safety issues pertaining to lisuride, to cocaine, and to its interaction in a chronic, crack dependent population, and to determine how pretreatment with lisuride modifies the…
- Trial name
- NCT00000338
- Testing
- Lisuride
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Nicotine Dependence
Progesterone and Atomoxetine for Cocaine Cessation
The purpose of this study is to examine the role of progesterone (a hormone found in both men and women) on stopping cocaine use.
- Trial name
- NCT01741376
- Testing
- Progesterone
- Where
- United States
- Sponsor
- University of Minnesota