Clinical trials: Cocaine-related Disorders
Cocaine-Related Disorders
Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the brain.
- Trial name
- NCT00134901
- Testing
- Memantine
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- New York State Psychiatric Institute
Cocaine Abuse
Galantamine Effects on Cognitive Function in Abstinent Cocaine Users
To evaluate galantamine's effects on cognitive performance in abstinent cocaine users. Galantamine, a medication approved for treatment of Alzheimer's disease, is an acetylcholine esterase inhibitor.
- Trial name
- NCT00606801
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Yale University
Cocaine-Related Disorders
Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.
- Trial name
- NCT00032929
- Testing
- Selegiline
- Where
- 16 sites in United States
- Volunteers
- 269 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Addiction, Cocaine-Related Disorders
Benefits of Therapy With Virtual Reality Exposure in the Treatment of Cocaine Use Disorders
Cocaine addiction is a multifactorial disease with important consequences: somatic, psychiatric... The number of applications for treatment for cocaine addiction is gradually increasing from year to year but no conventional…
- Trial name
- CORVI (NCT04280900)
- Testing
- Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), Treatment as usual
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cocaine Use Disorder, Tobacco Use Disorder
Single and Multiple Rising Dose Study of Safety and PK of Metyrapone/Oxazepam Combination (EMB-001)
This is a study of EMB-001 (a combination of two FDA-approved drugs, metyrapone and oxazepam) in otherwise healthy adults who are regular cigarette smokers.
- Trial name
- NCT02406066
- Testing
- metyrapone & oxazepam
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Embera NeuroTherapeutics, Inc.
Cocaine Dependence
Striatal Effective Connectivity to Predict Treatment Response in Cocaine Misuse
This project proposes to investigate the role of brain connectivity in the mechanism of treatment response to dopaminergic medications in cocaine dependence.
- Trial name
- NCT02080819
- Testing
- levodopa/carbidopa 400/100 BID
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Cocaine Dependence
PET Imaging in Cocaine Self Administration
There has been recent interest in the role of the 5-HT1B receptor as a possible modulating factor in cocaine dependence, certainly in preclinical models.
- Trial name
- NCT02181491
- Testing
- [11C]-P943
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yale University
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Cocaine Related Disorders
Brain Imaging of Cocaine Craving in Recreational Cocaine Users
The purpose of this study is to compare individuals with cocaine dependence to recreational users of cocaine in terms of their brain reactivity to cocaine cues, in hopes that this comparison may help us better understand the…
- Trial name
- NCT01189578
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- James J. Prisciandaro
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
COCAINE-RELATED DISORDERS
Improving Learning-based Treatment of Cocaine Dependence With Medication
This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.
- Trial name
- NCT01526538
- Testing
- d-cycloserine, sugar pill
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cocaine Dependence
Exercise as an Adjunctive Treatment for Cocaine Dependent Patients
The purpose of this study is to evaluate if exercise added to usual treatment improves cocaine dependence treatment. The primary objective of this study is to investigate if exercise can facilitate cocaine craving reduction.
- Trial name
- NCT01832649
- Testing
- Exercise, Health education
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cocaine-Related Disorders
Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1
To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.
- Trial name
- NCT00094315
- Testing
- Cocaine (IV)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Citalopram for Cocaine Dependence
This is a phase 2 clinical trial of citalopram pharmacotherapy for treatment of cocaine dependence. Using a double-blind, randomized controlled design, eligible cocaine dependent patients will be assigned equally to one of three…
- Trial name
- NCT01535573
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Joy Schmitz
Cocaine Dependence
Treating Cocaine Abuse: A Behavioral Approach
This study is designed to advance our development of a treatment for cocaine dependence. The investigators hypothesize that clients with high-risk characteristics will benefit from enhanced levels of treatment.
- Trial name
- NCT01822327
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Vermont
Cocaine Dependence
Randomized, Double-blind, Placebo-controlled Cannabis Extract x Placebo for Cocaine Addicts
2.1. General To evaluate the efficacy and safety of a Cannabis sativa extract (CBD (Cannabidiol) + up to 0.3% THC (Delta-9-tetrahydrocannabinol)), compared to placebo, in the treatment of cocaine/crack use disorder. 2.2.
- Trial name
- NCT06159387
- Testing
- Cannabis Extract Oil SR Capsule
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Cocaine-Related Disorders
Rapid Evaluation of Baclofen for Treatment of Cocaine Abuse/Dependence - 6
The purpose of this study is to empirically test a series of medications to: 1) determine each medication's efficacy in treatment of cocaine abuse/dependence; 2) find most effective dose range for each medication.
- Trial name
- NCT00000303
- Testing
- Baclofen
- Where
- United States
- Sponsor
- University of California, Los Angeles
Cocaine Dependence
Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues
Cocaine dependence is a chronic, relapsing disorder in which stress/negative mood and exposure to drug-related stimuli or "cues" are associated with high rates of relapse (McKay et al., 1995; O'Brien et al., 1998; R.
- Trial name
- NCT00585520
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders
Pilot Study Examining Effect for Dextroamphetamine to Treat Cocaine Dependence Plus Attention-deficit Hyperactivity Disorder (ADHD)
Dextroamphetamine is commonly used to treat ADHD, and recent evidence suggests that this medication may decrease drug use in individuals dependent on cocaine.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Cocaine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00514202
- Testing
- Dextroamphetamine SR
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center, Houston