Clinical trials: Coeliac Disease
Non-celiac Wheat Sensitivity
Self-reported Gluten Sensitivity in High-school Students
It has been reported that a consistent percentage of the general population consider themselves to be suffering from problems caused by wheat and/or gluten ingestion, even though they do not have celiac disease or wheat allergy.
- Trial name
- NCT03021148
- Testing
- Questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Palermo
Pancreas Cancer, Biliary Tract Cancer
Surgery Plus Celiac Nerve Block for Long-term Pancreatic Cancer Pain Control
This is a randomized study of surgery plus chemical nerve block versus surgery plus placebo for pain control in subjects with pancreatic cancer.
- Trial name
- NCT02002806
- Testing
- Alcohol Injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Digestive System Neoplasms
Celiac Plexus Radiosurgery for Pain Management
This prospective study evaluates celiac plexus radiosurgery for pain control in patients with upper abdominal malignancies.
- Trial name
- NCT02356406
- Testing
- Celiac Plexus Radiosurgery
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Sheba Medical Center
Advanced Cancer, Pancreas Cancer
Celiac Plexus Radio-Surgery for Pain Management
Many cancer patients, especially those with pancreatic cancer, suffer from severe lower back / upper abdominal pain. This pain is often poorly managed with standard treatments; the doses of painkiller required often induce side…
- Conditions
- Advanced Cancer, Pancreas Cancer, Pain
- Trial name
- NCT03323489
- Testing
- Celiac Plexus Radiosurgery
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 125 people
- Sponsor
- Dr. Yaacov Lawrence
Pancreatic Ductal Adenocarcinoma (PDAC)
European Appleby Registry for Pancreatic Cancer
The EURO-APPLEBY Registry is a prospective, multicenter European observational registry designed to characterize contemporary surgical practice and evaluate perioperative and long-term oncological outcomes in patients undergoing…
- Trial name
- EURO-APPLEBY (NCT07889180)
- Volunteers
- 100 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Celiac Disease
Clinical Trial on the Effects of Bifidobacterium Infantis in Active Celiac Disease
This exploratory study has been designed to determine the effect of the probiotic Bifidobacterium infantis vs. placebo orally administered over a period of 3 weeks on clinical features, Quality of Life parameters (QoL)…
- Trial name
- Celiac (NCT01257620)
- Testing
- Probiotic
- Where
- Argentina
- Volunteers
- 22 people
- Sponsor
- Bai, Julio M.D.
Celiac Disease
VTP-1000 in Adults With Celiac Disease
GLU001 is a first-in-human clinical trial to assess the safety and tolerability of VTP-1000 for adults with celiac disease. This trial will assess VTP-1000 at various dose levels compared to placebo in a single ascending dose…
- Trial name
- NCT06310291
- Testing
- VTP-1000
- Where
- 16 sites in United States
- Volunteers
- 45 people
- Sponsor
- Barinthus Biotherapeutics
Pancreatic Cancer
EUS-guided Celiac Plexus Neurolysis for the Treatment of Abdominal Pain in Pancreatic Cancer
Studies have shown that injecting local anesthetics in areas rich in blood vessels increases the risk of drug injection into blood vessels by mistake and increases the systemic absorption of drugs, which may increase the…
- Trial name
- NCT03940027
- Testing
- EUS-guided celiac plexus neurolysis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Coeliac Disease
Cardiovascular Risk Factors in Coeliac Disease: a Series of Studies
This investigation examines the most important cardiovascular risk factors (e.g., metabolic parameters, body composition) and their changes in coeliac disease.
- Trial name
- ARCTIC (NCT05530070)
- Testing
- Dietary intervention, Standard of care, Cardiovascular risk-related parameters
- Where
- Hungary
- Volunteers
- 190 people
- Sponsor
- University of Pecs
Celiac Disease
Pre-endoscopy Serological Testing for Coeliac Disease; a Novel Approach Using Rapid Antibody Testing
The aim of this study is to assess the clinical utility of the whole blood transglutaminase-based rapid test against current serological tests and the gold standard of duodenal biopsy.
- Trial name
- NCT02834429
- Where
- United Kingdom
- Volunteers
- 1,596 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Coeliac Disease, Celiac Disease in Children
Supporting Children and Young People to Live Well With Coeliac Disease: A RCT
Managing a strict gluten-free diet is crucial for children and young people with coeliac disease. However, this can have adverse effects on psychological well-being and quality of life.
- Trial name
- NCT06930924
- Testing
- Parent self-help psychological resource
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Surrey
Celiac Disease
Study to Assess the Efficacy of Larazotide Acetate for the Treatment of Celiac Disease
This study was conducted to evaluate the efficacy of multiple doses of larazotide acetate in preventing intestinal permeability changes induced by a 6- week gluten challenge in subjects with celiac disease.
- Trial name
- NCT00492960
- Testing
- larazotide acetate, 900 mg gluten
- Where
- 23 sites in United States, Canada
- Volunteers
- 171 people
- Sponsor
- 9 Meters Biopharma, Inc.
Coeliac Disease
Diagnostic Accuracy of IgA Anti-transglutaminase Antibodies Measured by CLIA for Predicting Villous Atrophy in Coeliac Disease
Celiac disease (CD) is an autoimmune disorder in which ingestion of gluten leads to immune-mediated damage of the small intestine. Diagnosis has traditionally required histological confirmation of duodenal villous atrophy.
- Trial name
- NCT07364461
- Where
- Spain
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Pain, Pancreatic Cancer
Safety and Efficacy of Cryoablation for Abdominal Pain Associated With Pancreatic Cancer
CUC10-PAN09 will evaluate the safety and efficacy of cryoablation therapy on the relief of epigastric/abdominal pain associated with pancreatic cancer.
- Trial name
- NCT01335945
- Testing
- Cryoablation
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Boston Scientific Corporation
Celiac Disease
T Cell Receptor (TCR) Sequencing and Transcriptional Profiling in Adult Celiac Disease Patients Undergoing Gluten Challenge
The primary objectives are: Characterize the T cell receptor (TCR) repertoire in duodenal biopsy samples of participants pre- and post-challenge.
- Trial name
- NCT04614571
- Testing
- Gluten Powder
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Regeneron Pharmaceuticals
Non-celiac Gluten Sensitivity; Adolescents
Non Celiac Gluten Sensitivity, DBPCFC in Adolescents
In a population based on healthy adolescents we will conduct a double blind placebo controlled food challenge (DBPCFC) with cross-over to identify patients with NCGS as recommended by the socalled Salerno criteria.
- Trial name
- NCT04639921
- Testing
- positive test followed by gluten-free diet
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Celiac Disease
In Vivo Effects of the Gluten Friendly Bread in Coeliac Disease
In the last two decades, a series of epidemiological studies have shown a particular increase in Coeliac Disease (CD), a life-long intolerance to gluten proteins (the seed storage proteins) present in most cereals (wheat, barley…
- Trial name
- NCT03168490
- Testing
- Gluten Friendly bread
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Roehampton
Celiac Disease
Desensitising Celiac Disease Patients With the Human Hookworm
We have established that the hookworm Necator americanus (Na) dramatically alters the local and systemic immune landscape of the infected human host.
- Trial name
- NaCeD (NCT01661933)
- Testing
- Necator americanus
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- The Prince Charles Hospital
Pancreatic Cancer
EUS-CPN With and Without Bupivacaine
Endoscopic ultrasound (EUS) allows EUS-guided trans gastric injection of absolute alcohol around the base of the celiac plexus (celiac plexus neurolysis (EUS-CPN)), to help alleviate pain associated with pancreatic cancer.
- Trial name
- EUS-NB (NCT04951804)
- Testing
- EUS-CPN without bupivacaine, EUS-CPN with bupivacaine
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Celiac Disease
A Study of Guselkumab in Adult Participants With Celiac Disease
The purpose of this study is to evaluate the safety and tolerability of guselkumab compared to placebo in participants with celiac disease.
- Trial name
- NCT04704843
- Testing
- Guselkumab
- Where
- 4 sites in United States
- Sponsor
- Janssen Research & Development, LLC