Clinical trials: Coeliac Disease
Celiac Disease, Food Intolerance
Immunosafe-CeD: Are Partially Hydrolysed Gluten Harmful to Celiac Disease Patients?
The study will compare the immune response in CeD patients to wheat and barley gluten at high doses (1 gram), and also investigate the reponses to low dose barley gluten and also hydrolyzed, malted barley and placebo.
- Trial name
- NCT06151782
- Testing
- Wheat gluten 1000 mg, Barley gluten 1000 mg, Barley gluten 50 mg
- Where
- 2 sites in Germany, Norway
- Volunteers
- 33 people
- Sponsor
- Oslo University Hospital
Celiac Disease
Safety Study of Larazotide Acetate to Treat Celiac Disease.
To demonstrate the safety, pharmacokinetics and efficacy of larazotide acetate in patients with controlled celiac disease on a gluten-free diet following a gluten challenge.
- Trial name
- NCT00386165
- Testing
- larazotide acetate
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- 9 Meters Biopharma, Inc.
Celiac Disease in Children, Gluten Enteropathy
Influence of a Gluten Free Food Guide on Diet Quality and Adherence to the GFD in Youth With Celiac Disease
Celiac disease (CD) is an autoimmune gastrointestinal disease that is caused by intolerance to gluten in the diet. The mainstay of treatment is a gluten-free diet (GFD).
- Conditions
- Celiac Disease in Children, Gluten Enteropathy, Diet; Deficiency, Adherence, Treatment
- Trial name
- NCT06038344
- Testing
- Gluten-free food guide teaching
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Celiac Disease
Efficacy of Cholesterol-lowering L. Plantarum on Cardiometabolic Health Biomarkers in Coeliac Disease Patients
Recent studies have also shown that 30% of the world's population carries the susceptibility genes for coeliac disease and that only 2-5% of these individuals are really affected, however, studies suggest the existence of other…
- Trial name
- ProCoChoL (NCT06178107)
- Testing
- LP-LDL Probiotic
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Celiac Disease
Educational Intervention on Celiac Disease and Gluten-free Diet Through Social Networks (GLUTLEARN Project).
Celiac disease (CD) is an autoimmune disease that occurs in people who are genetically predisposed to gluten consumption (1). The prevalence of the disease is about 1-2% and it is more common in women than in men, and in children…
- Trial name
- GLUTLEARN (NCT05923346)
- Testing
- GLUTLEARN
- Where
- Spain
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of the Basque Country (UPV/EHU)
Prevention of Clinical Symptoms in Celiac Disease
Risk Factors for the Development of Celiac Disease in Genetically Predisposed Children
The study aims to identify risk factors for the development of Celiac Diseases in families with a recognized genetic risk for the presence of a confirmed proband case.
- Trial name
- NEOCEL (NCT04034303)
- Testing
- analysis of genetic and epigenetic risk factors
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Federico II University
Celiac Disease, Dermatitis Herpetiformis
Study of Enzyme Supplements to Treat Celiac Disease
The purpose of this study is to examine whether a cocktail of two common food-grade enzyme supplements leads to decrease of serum activity markers in celiac disease patients insufficiently treated by previous gluten exclusion.
- Trial name
- NCT00962182
- Testing
- STAN1, STAN1+gluten
- Where
- 2 sites in Hungary
- Volunteers
- 38 people
- Sponsor
- Heim Pal Children's Hospital
Celiac Disease
Behavioral Intervention for Celiac Disease
Celiac disease (CD) is a chronic autoimmune condition whose only currently available treatment is a strict, burdensome gluten-free diet (GFD).
- Trial name
- NCT05204446
- Testing
- GROW Project, GROW+ Project
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Children's National Research Institute
Not-celiac Wheat Sensitivity
Bio-markers of Not-celiac Wheat Sensitivity
The aim of the investigators' study is to evaluate biochemical, immunological and histological characteristics of patients affected with the so-called "gluten (or wheat) sensitivity" who suffers from irritable bowel syndrome…
- Trial name
- NCT01762579
- Testing
- wheat flour, Xylose
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Gluten Sensitivity
Assessment of the Effect of Gluten Free Toothpaste on the Ulcerative Events in Children With Celiac Disease
Celiac disease (CD) is the most common genetically based food intolerance in the world, with a prevalence among approximately 1% of the general population (Guandalini \& Assiri, 2014).
- Trial name
- NCT03771443
- Testing
- experimental gluten free toothpaste
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Gastrointestinal Hemorrhage, Crohn Disease
Prucalopride Prior to Small Bowel Capsule Endoscopy
Small bowel capsule endoscopy is a test used to investigate for any abnormalities in the small bowel. The small bowel is about 4 meters long. The battery time of the capsule is about 8 hours.
- Conditions
- Gastrointestinal Hemorrhage, Crohn Disease, Celiac Disease, Intestinal Diseases
- Trial name
- NCT02806206
- Testing
- Prucalopride
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- University of British Columbia
Sjogren's Syndrome, Non-celiac Gluten Sensitivity
Wheat-free Diet in the Treatment of Sjogren's Syndrome
Recent data show that some foods can increase intestinal mucosa permeability and immune activation of subjects with gastrointestinal (GI) symptoms.
- Trial name
- NCT05644795
- Testing
- Wheat/milk free diet (W/MFD) group, Rice/turkey free diet (R/TFD) group
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Celiac Disease
The Aim of This Project is to Verify Whether a Depletion of B Cell Memory Subpopulation ("Marginal-zone-like") CD19 + IgD + CD27 + and CD19 + IgM + CD27 + is a Useful Indicator of Hyposplenism in Patients With Celiac Disease
This project is expected to confirm the hypothesis that hyposplenism in patients with celiac disease is not conditioned by a selective memory deficiency of B lymphocytes.
- Trial name
- NCT03763487
- Testing
- venous blood sampling, spleen volumetry
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Hradec Kralove
Tryptophan Metabolism Alterations, Celiac Disease
Tryptophan for Impaired AhR Signaling in Celiac Disease
This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD)…
- Trial name
- TIARSCeD (NCT05576038)
- Testing
- L-Tryptophan, Freedom SimpleCap Powder
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Clinical Presentation, Celiac Disease
Clinical Presentation of Celiac Disease in Last 14 Years
The aim of this study is to: To determine the pattern of clinical presentations of celiac disease (CD) over the past 10 - 14 years in Egyptian children. To study the various clinical presentation of CD in Egyptian children.
- Trial name
- NCT07842848
- Testing
- Retrospective Medical Record Review
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Celiac Disease
Oral AGY for Celiac Disease
Celiac disease (CD) is an autoimmune disease of the small intestine caused by the consumption of gluten proteins from widely used food sources such as wheat, rye, and barley.
- Trial name
- NCT01765647
- Testing
- AGY
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Igy Inc.
Celiac Disease
Gluten Free Oat (Cultivar Saul) in Celiac Disease in Remission
The goal of this clinical trial is to evaluate the tolerability of the oat cultivar Saul, previously characterized by low celiac disease-related immunoreactivity, in adults with celiac disease in sustained clinical and…
- Trial name
- GFOATSAUL (NCT07515105)
- Testing
- certified gluten-free oats of the Saul variety
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Chronic Pancreatitis, Inflammatory Bowel Diseases
Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study
This is a prospective, descriptive, observational research study designed to observe and document the clinical practice by domain experts, and how the knowledge of new findings that are published in the medical literature affect…
- Conditions
- Chronic Pancreatitis, Inflammatory Bowel Diseases, Hepatitis, NASH - Nonalcoholic Steatohepatitis
- Trial name
- GREAT1 (NCT04306939)
- Testing
- venipuncture, Questionnaires, Additional Sample Collections
- Where
- United States
- Volunteers
- 120,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Celiac Disease
Study to Evaluate the Efficacy and Safety of Larazotide Acetate for the Relief of CeD Symptoms
To assess the efficacy and safety of larazotide acetate versus placebo for the relief of persistent symptoms in adult celiac disease patients.
- Trial name
- NCT03569007
- Testing
- Larazotide
- Where
- 160 sites in United States
- Volunteers
- 307 people
- Sponsor
- 9 Meters Biopharma, Inc.