Clinical trials: Cognition Disorder
Spinal Cord Injury
Magnetic Resonance Imaging of Cognitive Deficits in the Brain of Individuals With Spinal Cord Injury
In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date.
- Trial name
- SCI_Cog (NCT06309888)
- Where
- Switzerland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Swiss Paraplegic Research, Nottwil
Healthy
Effects of Intranasal Oxytocin and Vasopressin on Social Behavior and Decision Making
The purpose of this study is to investigate the role of a one-time intranasal administration of the oxytocin, vasopressin, or placebo on prosocial decision making such as cooperation and competition in a healthy population of…
- Trial name
- NCT02526914
- Testing
- Intranasal Oxytocin, Intranasal vasopressin
- Where
- Israel
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- David Mankuta
Spinal Cord Injuries, Cardiovascular Abnormalities
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls…
- Conditions
- Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
- Trial name
- NCT05542238
- Testing
- One bout of moderate-intensity sub-maximal aerobic exercise
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Nicotine Dependence, Schizophrenia
Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia
Background: Some people with schizophrenia have problems with their working memory and paying attention for extended periods. These difficulties cannot be treated with antipsychotic medications or with many standard therapies.
- Trial name
- NCT01034085
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Autism Spectrum Disorder (ASD), Intellectual Disability
Emotion Intensity Modulates Intention in ASD
This study used eye-tracking to examine how emotional expression intensity (low/medium/high) influences intention understanding in children with ASD, PDD, and TD during a puzzle-search task.
- Trial name
- NCT07597655
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Alteration of Cognitive Function, Hypoxia
Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers
The early assessment of new symptomatic drugs for Alzheimer disease remains difficult because of the lack of predictive end-point. The use of a battery including different parameters could improve this early development.
- Trial name
- Hypoxia (NCT02891343)
- Testing
- 2-hour period of hypoxia
- Where
- 2 sites in France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Listening Effort, Cognitive Function 1, Social
The Effect of Listening Effort, Cognition and Anxiety-depression in Listening Satisfaction by Hearing Aid Users
Brief Summary Introduction: Listening can be effortful in situations that require the intensive use of cognitive processing resources especially for individuals with a hearing loss.
- Conditions
- Listening Effort, Cognitive Function 1, Social, Anxiety, Depression
- Trial name
- NCT05781126
- Testing
- The Spatial Hearing Questionnaire, MINI-MENTAL STATE EXAMINATION, International Outcome Inventory - Hearing Aid, Glasgow Hearing Aid Benefit Profile, BECK-II and STAI questionnaires
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chania General Hospital "St. George"
Major Depressive Disorder (MDD), Neuroimaging
Efficacy of Bright Light Therapy on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms: Protocol for a Randomised Controlled Trial
This study aims to validate the therapeutic efficacy and safety of bright light therapy (BLT) in ameliorating cognitive impairment (CI) in major depressive disorder (MDD), characterize the functional and structural features of…
- Conditions
- Major Depressive Disorder (MDD), Neuroimaging, Bright Light Treatment, Cognitive Impairment
- Trial name
- NCT07508215
- Testing
- BLT, DRL
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Geriatric Patients in a Pre-rehabilitative Treatment, Mild Cognitive Impairment (MCI)
Monitoring and Cognitive Appraisal: The Etiology of Psychological Disorders and The Divergence Between Behavioural and Self-reported Data
The study investigates the etiology of psychogical disorders from a neuropsychological perspective based on monitoring and cognitive appraisal.
- Trial name
- NCT07137676
- Testing
- AX-CPT, No Interventions
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Franziskus Hospital
Vestibular Dysfunction, Dizziness
Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks
This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same…
- Conditions
- Vestibular Dysfunction, Dizziness, Falls (Accidents) in Old Age, Balance Assessment
- Trial name
- NCT07735078
- Testing
- Instrumented balance and gait assessment using wearable inertial sensors, Questionnaires and paper-based cognitive tests
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Alzheimer Disease (AD)
Daridorexant for Alzheimer Disease Prevention
This study will evaluate whether daridorexant, a DORA sleep medication, can support brain health by promoting the clearance of proteins linked to the development and progression of Alzheimer's disease.
- Trial name
- PAD-DORA (NCT07213349)
- Testing
- Daridorexant 50 mg
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Bone Tumor, Cancer of Bone
Endoprosthesis Metal Toxicity Study
The purpose of this research is to investigate whether patients who previously had endoprosthesis surgery experience memory, thinking, or heart problems. It will also help determine how often these problems occur.
- Conditions
- Bone Tumor, Cancer of Bone, Heart Diseases, Cognitive Impairment
- Trial name
- NCT04755140
- Testing
- Questionnaires, Interviews, Blood Test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Occupational Therapy, Cognition Disorders in Old Age
Study of a Daily Cognition Training Program
HYPOTHESIS In older adults who receive a direct intervention from the perspective of occupational therapy with a "Training Program in Daily Cognition", there are greater benefits, both in the overall cognitive performance and in…
- Conditions
- Occupational Therapy, Cognition Disorders in Old Age, Cognitive Dysfunction, Rehabilitation
- Trial name
- NCT04041999
- Testing
- Daily Cognition Training Program
- Where
- Spain
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Bilateral Salpingo-oophorectomy
Sleep in Women With Bilateral Salpingo-Oophorectomy
The purpose of this research study is the compare objective and subjective sleep characteristics in women who have undergone removal of both ovaries (bilateral salpingo-oophorectomy) before natural menopause compared to women who…
- Trial name
- NCT04565158
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sedentary Behavior, Cognitive Impairment
iBAILA - Investigating Brains & Activity to Improve Latino Aging
Examine the impact of the BAILAMOS (TM) dance program on lifestyle physical activity
- Trial name
- NCT04544358
- Testing
- BAILAMOS©
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cognitive Impairment, Depression
The Efficacy of Omega-3 Fatty Acids in Maintaining Optimal Mental Health in Elderly People
The efficacy of EPA-DHA supplementation will be assessed in a randomized placebo-controlled trial with cognitive decline and early signs of depression as primary outcome measures.
- Trial name
- NCT00124852
- Testing
- n-3 Fatty Acid Supplementation
- Where
- Netherlands
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- ZonMw: The Netherlands Organisation for Health Research and Development
Cognition, Anxiety
Biopsychosocial Effects of Gardening Activities
Due to the increasing number of elderly population worldwide, elderly care is becoming increasingly important and the number of elderly in institutional care is increasing.
- Conditions
- Cognition, Anxiety, Depression, Life Satisfaction
- Trial name
- NCT06844084
- Testing
- Gardening Activity
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ordu University
Dementia, Mild, Mild Cognitive Impairment
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
The purpose of this study is to test the adapted protocol, CAPABLE Family which builds upon the evidenced based CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early…
- Conditions
- Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive
- Trial name
- NCT05187117
- Testing
- CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Alzheimer Disease
Trial of CORT108297 to Attenuate the Effects of Acute Stress in the Allocortex (CORT-X)
CORT-X will examine if mitigation of stress-mediated pathogenesis of Alzheimer's disease (AD) is a feasible target for intervention in individuals at risk for this disease.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Impairment
- Trial name
- CORT-X (NCT04601038)
- Testing
- CORT108297
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Frail Elderly
Long-term Effects of Interventional Strategies to Prevent Cognitive Decline in Elderly.
The MAPT PLUS study is a two-year extension of follow-up of the patients included in the MAPT preventive study, after completion of the interventions. Subjects in the four groups of the MAPT study will be prospectively followed.
- Trial name
- MAPT-PLUS (NCT01513252)
- Testing
- Gröber and Buschke test
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,028 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
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