Clinical trials: Cognition Disorder
Mild Cognitive Impairment
Effect of Mediterranean Diet and Probiotics in Adults With Mild Cognitive Impairment
Manipulation of the gut microbiota through dietary modification affects brain function, with improvement in patients with cognitive disorders.
- Trial name
- NCT05029765
- Testing
- Mediterranean diet, Healthy diet (WHO recommendations), Biopolis-MIX42
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Pablo Pérez Martínez
Stellate Ganglion Block
The Effect of Stellate Ganglion Block on Postoperative Sleep Disturbance and Cognitive Function in Elderly Surgical Patients
Postoperative delirium is an acute state of confusion, which is characterized by changes in attention and cognitive functions and fluctuations in consciousness; postoperative cognitive dysfunction is a common central nervous…
- Trial name
- NCT04800653
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Yangzhou University
Mild Cognitive Disorder, Alzheimer Disease
Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective, Longitudinal Register Study Including People With Mild Cognitive Impairment and Dementia as Well as Their Family Caregivers
Around 57 million people worldwide live with dementia, with approximately 10 million new cases diagnosed each year. By the end of 2023, around 1.8 million people were living with dementia in Germany, the majority of whom were…
- Conditions
- Mild Cognitive Disorder, Alzheimer Disease, Vascular Dementia, Dementia in Other Diseases Classified Elsewhere
- Trial name
- digiDEM Bayern (NCT07721701)
- Where
- 12 sites in Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Alzheimer Disease (AD), Cognitive Decline
Establishing Clinical Utility Evidence for a Novel Alzheimer's Disease Blood-Based Biomarker Assay
This is a national-level research study of neurologists and dementia specialists. The purpose of this study is to assess the clinical evaluation and management recommendations made by practicing providers for patient simulations…
- Trial name
- NCT07099001
- Testing
- Educational materials on the Alzheimer's disease assay, Alzheimer's disease assay results
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Qure Healthcare, LLC
Cerebrovascular Diseases
Treatment of Mild Vascular Cognitive Impairment With Yangxue Qingnao Pill
In this study, the effectiveness of vascular cognitive impairment was compared among the three groups, namely, the xidezhen group, the Yangxue Qingnao pill group and the placebo group
- Trial name
- NCT04958512
- Testing
- Yangxue Qingnao pill, Hydergotoxine mesylate tablets, blank control group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Cognitive Impairment, Mild, Dementia
Effects of Training Dose on Computerized Cognitive Training in Patients With Cognitive Impairment
The goal of this observational study is to explore the optimal dose of computerized cognitive training in patients with cognitive impairment.
- Trial name
- NCT05922319
- Testing
- Computerized cognitive training with different training doses
- Where
- China
- Volunteers
- 21,845 people
- Sponsor
- Xuanwu Hospital, Beijing
No Condition
Domain-general and Domain-specific Contributions to the Development of Numerical Cognition
Exploring the non-symbolic and symbolic arithmetic competencies in two groups of children (5-, and 7-year-olds). Additionally, we explored the relationship with domain-general factors such as inhibition and attention.
- Trial name
- CFDDCN (NCT06658392)
- Testing
- cognitive tasks
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Chronic Low Back Pain, Spinal Cord Injury
SERENITY Study of Chronic Pain Interference in Adults
SERENITY is a remote observational study designed to characterize inter-individual differences in chronic pain among adults with chronic low back pain and adults with spinal cord injury-related neuropathic pain.
- Conditions
- Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain
- Trial name
- SERENITY (NCT07820475)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Multiple Sclerosis
High-intensity Training and Its Effects on Neuroplasticity
Regular physical activity is known to reduce the risk for some neurodegenerative disorders and their symptoms. Several studies have shown positive effects of therapeutic exercise interventions on motor- and cognitive function as…
- Trial name
- TRAINUVIMAB (NCT03652519)
- Testing
- Exercise Training
- Where
- Switzerland
- Volunteers
- 72 people
- Sponsor
- Klinik Valens
General Health and Wellness, Energy and Vitality
M4C Nutraceutical Intervention Human Health Effects Pilot
This 3 month pilot study will be an unblinded, convenience sampling, nutraceutical intervention trial. Twenty fasted subjects will undergo a baseline health assessment via a questionnaire, baseline clinical chemistries, blood…
- Conditions
- General Health and Wellness, Energy and Vitality, Cognitive Function and Mental Health, Weight Management
- Trial name
- M4C Pilot (NCT06476236)
- Testing
- M4C
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Concordia University Wisconsin
Stroke
Exergames on an Unstable Surface in Stroke Inpatients
Aim of this study is to assess the feasibility and effects of exergame-based cognitive-motor training on a labile platform on physical and cognitive functioning in stroke inpatients.
- Trial name
- NCT06296069
- Testing
- exergame-based cognitive-motor training on an unstable surface, exergame-based cognitive-motor training on an stable surface
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- Eleftheria Giannouli
Dementia, Sleep Disorder
Develop Novel Phototherapy for Health Care of Patients With Sleep Disorder, Mild Cognitive Impairment, or Dementia
Investigators aim to collaborate with the division of neurology, ophthalmology and dermatology at the Kaohsiung Medical University, and make a new phototherapy for participants suffering from dementia, sleep disorder, mild…
- Conditions
- Dementia, Sleep Disorder, Mild Cognitive Impairment, Phototherapy
- Trial name
- NCT04407351
- Testing
- Green LED light
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Mild Cognitive Impairment
The Effects of an Extensive Exercise Program on the Progression of Mild Cognitive Impairment
Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by…
- Trial name
- NeuroExercise (NCT02913053)
- Testing
- Aerobic exercise, Non-aerobic exercise
- Where
- 3 sites in Germany, Ireland and 1 more
- Volunteers
- 183 people
- Sponsor
- Radboud University Medical Center
Chronic Pain, Insomnia
Insomnia and Cognitive Performance in Chronic Pain
The aim of the present study is to examine cognitive function in a patient population with complex chronic pain to test the hypothesis that insomnia severity on its own predicts objective cognitive function, and that a…
- Trial name
- NCT03072745
- Testing
- Neuropsychological assessment
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Uppsala University
Alzheimer's Disease, Dementia
A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023)
This study will evaluate acute symptomatic improvements in cognitive performance in healthy elderly participants with mild-to-moderate Alzheimer's disease.
- Trial name
- NCT00874939
- Testing
- MK-0249 7.5 mg, MK-0249 25 mg, Donepezil 5mg
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Psychoses, Substance-Induced
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Ketamine, an FDA approved anesthetic agent, is becoming the sedative/analgesic of choice for emergency sedation in children because it causes deep sedation with minimal respiratory depression in comparison to other available…
- Trial name
- NCT00205712
- Testing
- Ketamine, Dexmedetomidine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
GTA-MEG as a Biomarker for Cognition in MS
In this study, 100 persons with Multiple Sclerosis and 50 matched controls will be examined with magnetoencephalography (MEG), magnetic resonance imaging (MRI) and cognitive tests.
- Trial name
- NCT02851342
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Alzheimer Disease
Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, 6-period crossover study to evaluate the effects of BPN14770 10 mg and 50 mg in reversing scopolamine-induced cognitive impairment in healthy volunteers.
- Trial name
- NCT03030105
- Testing
- BPN14770, Donepezil, Scopolamine 0.6 MG/ML
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Tetra Discovery Partners
Cognitive Decline, Cognitive Impairment
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1…
- Trial name
- EFFECT (NCT06223672)
- Testing
- Walnuts, Simply White Diary-free chocolate bar
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Ohio State University