Clinical trials: Cognition Disorders in Old Age
Mild Cognitive Impairment
Feasibility Study of Virtual Sail 3D in Cognitive Functions
This research project will assess the feasibility and preliminary effectiveness of a 6-week intervention to improve cognitive functions using the 3D immersive virtual reality software "CEREBRUM" with virtual sailing scenarios…
- Trial name
- NCT06579378
- Testing
- VSail 3D, WEB-Health
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Cagliari
Frail Elderly Syndrome, Cognitive Impairment
Investigating My Active and Healthy Aging
This is a multicenter, multicultural, randomized control trial. Participants will be recruited from 10 centers located in Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea and Australia.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Physical Dependence
- Trial name
- my-AHA (NCT03342976)
- Testing
- My-AHA platform
- Where
- Italy
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Cognitive Dysfunction, Mild Cognitive Impairment
Effect of Dual Task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment
The purpose of this study is to investigate the effect of the dual task exercise program on cognitive and physical function in the elderly with mild cognitive impairment.
- Trial name
- NCT05855785
- Testing
- dual task exercise, home exercise
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Boramae Hospital
Mild Cognitive Impairment (MCI)
Gamma tACS to Improve Cognitive Function in Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a decline in memory and thinking that exceeds normal aging but does not substantially disrupt daily life, and it raises the risk of developing dementia.
- Trial name
- TACS-MCI (NCT07752316)
- Testing
- transcranial electrical stimulation
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Alzheimer Disease, Dementia
Cognitive Impairment Cohort Study of the Elderly Population in SheMountain
This study is a prospective observational study, which involves a cohort of 2000 all-sex and all-ethnic people aged 60 years and above with permanent residence in Tianma area, SheMountain Town, Songjiang District (suburban area)…
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment
- Trial name
- SheMountain (NCT05667935)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal…
- Trial name
- NCT07392840
- Volunteers
- 50 people
- Sponsor
- Minia University
Postoperative Cognitive Dysfunction
Preoperative Pain and POCD in Elderly Patients
The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.
- Trial name
- NCT03393676
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Dementia, Alzheimer Disease
Treatment of Severe Alzheimer's Disease: Evaluation of Efficacy and Safety of Galantamine Hydrobromide in a Controlled Study
The purpose of this study is to assess the effectiveness and safety of galantamine hydrobromide treatment in patients with severe Alzheimer's disease.
- Trial name
- NCT00216593
- Testing
- galantamine hydrobromide
- Volunteers
- 415 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Dementia, Neurocognitive Disorders
Effect of Individual Reminiscence Therapy in the Elderly People With Neurocognitive Disorders
This research aims to evaluate the ability of individual reminiscence therapy (RT), using a simple reminiscence format, to improve the overall cognitive function, memory, emotional status and quality of life (QoL) of older adults…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04658394
- Testing
- Reminiscence therapy
- Where
- 13 sites in Portugal
- Volunteers
- 122 people
- Sponsor
- Rsocialform - Geriatria, Lda
Elderly Adults, Parkinson
A Treadmill Training Program Augmented by Virtual Reality to Decrease Fall Risk in Older Adults
The proposed randomized controlled trial will evaluate the effects of treadmill training augmented with virtual reality on fall risk. 300 older adults with a history of falls will be recruited to participate in this study.
- Conditions
- Elderly Adults, Parkinson, Mild Cognitive Disorder
- Trial name
- VTIME (NCT01732653)
- Testing
- TT+VR, TT alone
- Where
- 5 sites in Belgium, Israel and 3 more
- Volunteers
- 302 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Mild Cognitive Impairment
The Montreal Cognitive Assessment as a Screening Tool for Preoperative Mild Cognitive Impairment in Geriatric Patients
This is a prospective, double-blinded, control trial. The Montreal Cognitive Assessment is used to screen preoperative mild cognitive impairment in 582 consecutive geriatric patients, scheduled for general, vascular or urological…
- Trial name
- MoCA (NCT01496222)
- Where
- Thailand
- Volunteers
- 582 people
- Sponsor
- Mahidol University
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 3
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND3 (NCT05746273)
- Testing
- Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Opioid-Free Anesthesia, POCD
Effect of Opioid-free Anesthesia on Sleep Quality, Cognitive Function and Recovery Quality After General Anesthesia in Elderly Patients
Postoperative cognitive dysfunction (POCD)is a common well disorder of the central nervous system after surgery, mainly manifested by impaired memory, spirit, language ability or other aspects of brain function.
- Conditions
- Opioid-Free Anesthesia, POCD, Recovery Quality, Sleep Quality
- Trial name
- NCT06493396
- Testing
- Opioid-free Analgesics, Opioid group
- Volunteers
- 88 people
- Sponsor
- Beijing Friendship Hospital
Post Operative Delirium
Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients
This study aims to evaluate the efficacy of dexmedetomidine in reducing the incidence of postoperative delirium and cognitive dysfunction in elderly patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT06614881
- Testing
- Dexmedetomidine Injection [Precedex], Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML), Normal saline
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Tanta University
Functional Autonomy Level
Optimization of Drug Prescribing in an Elderly Population of Geriatric Consultations
Aging is often associated with multiple chronic conditions conducting increased consumption of drugs. Drug therapy is necessary for the treatment of many diseases.
- Trial name
- OPTIM (NCT02740764)
- Testing
- Optimization of drug prescribing
- Where
- 2 sites in France
- Volunteers
- 302 people
- Sponsor
- Hospices Civils de Lyon
Anesthesia, Cognitive Dysfunction
Evaluation of Cognitive Functions by Cerebral Pulse Oximetry
General and Spinal Anesthesia can be used in geriatric patients in orthopedic surgery. Post-op cognitive dysfunction can be seen in orthopedic surgeries in this group of patients.
- Trial name
- NCT03827083
- Testing
- cerebral pulse oximetry
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Sleep Disturbance
Intervention Study in Elderly With Sleep Problems
The main objective of the study is to improve subjective sleep quality using a multimodal intervention with an intervention and a control group. The multimodal intervention aims to improve circadian Zeitgeber strength.
- Trial name
- CIEL (NCT05485415)
- Testing
- Multimodal intervention, Control
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Mirjam Münch
Rheumatoid Arthritis, Rheumatic Diseases
Relationship Between Rheumatoid Arthritis Severity and Cognition in the Elderly: The Role of Nociplastic Pain
this study aims to determine if nociplastic pain mediates the relationship between rheumatoid arthritis (RA) severity and cognitive impairment in geriatric patients 100 patients aged 65-90 years with long-standing RA and assess…
- Conditions
- Rheumatoid Arthritis, Rheumatic Diseases, Rheumatoid Polyarthritis
- Trial name
- NCT05934721
- Testing
- Questionnaire and physical assessments
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahram Canadian University
Fall, Frailty
Combined Exercise and Cognitive Stimulation for Falls Prevention
Randomized clinical trial of 310 older adults over 75 years old recruited from the Falls Units of Geriatric Departments in 4 three University Hospitals in Spain (Pamplona, San Sebastián, Albacete and Barcelona).
- Conditions
- Fall, Frailty, Cognition Disorders in Old Age, Exercise
- Trial name
- Vivifrailcogn (NCT04911179)
- Testing
- Vivfrail-Cog combined multicomponent physical exercise and cognitive stimulation.
- Where
- Spain
- Volunteers
- 310 people
- Sponsor
- Fundacion Miguel Servet
Alzheimer's Disease
A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects
This is a randomized, double-blind (Investigator and subject-blinded) placebo-controlled, multiple, ascending-dose study to evaluate the safety, tolerability, and pharmacokinetic profile of BPN14770 in healthy young and elderly…
- Trial name
- NCT02840279
- Testing
- BPN14770
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Tetra Discovery Partners