Clinical trials: Cognition Disorders in Old Age
Cognitive Decline, Dietetic Intake
Trial of a Brain Preservation Diet in Preventing Cognitive Decline in Old Age Hostel Residents
Dementia is a major cause of disabilities in older people. If the onset of dementia can be delayed by preventive measures, the burden of the disease to the society can be greatly reduced.
- Trial name
- NCT01132261
- Testing
- "brain preservation' diet
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Chinese University of Hong Kong
Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD)
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian…
- Conditions
- Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Major Neurocognitive Disorder
- Trial name
- ITA-VALI-DEM (NCT06701630)
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Casa di Cura IGEA
Mild Cognitive Impairment, Alzheimer Disease
Study of the Efficacy and Safety of Various Anti-inflammatory Agents in Participants With Mild Cognitive Impairment or Mild Alzheimer's Disease
The purpose of this platform study was to evaluate the effect of anti-inflammatory agents on cognition in early Alzheimer's disease.
- Trial name
- NCT04795466
- Testing
- Canakinumab
- Where
- 10 sites in United States, Finland and 2 more
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals
Stroke
Telerehabilitation Program Bases Aerobic and Baduanjin Exercises in Post Stroke Elderly Patients
It is an interventional study in which 68 stroke patients are estimated to be enrolled according to random allocation and will be divided into two groups.
- Trial name
- NCT06278259
- Testing
- Telerehabilitation program bases aerobic and Baduanjin exercises, Telerehabilitation program bases aerobic exercises
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Alzheimer Disease, Cognitive Decline
40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations
This study aims to compare the efficacy of different 40 Hz tACS protocols in entraining gamma oscillations, which are linked to various cognitive functions and play a significant role in cognitive impairments like Alzheimer's…
- Trial name
- NCT06740864
- Testing
- Transcranial alternating current stimulation
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Memory Impairment, Age-related Cognitive Decline
Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging
This interventional, randomised, placebo-controlled and double-blind study aims to evaluate the effect of a dietary supplementation with a blue fish hydrolysate derived from marine by-products, containing peptides and n-3…
- Trial name
- BRAINBOOSTER (NCT04910399)
- Testing
- Blue fish hydrolysate
- Where
- 2 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Abyss Ingredients
Elective Surgery, Postoperative Cognitive Dysfunction
Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty
Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2.
- Conditions
- Elective Surgery, Postoperative Cognitive Dysfunction, Knee Arthroplasty
- Trial name
- NCT04225702
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Dementia, Cognitive Impairment
Physical Activity and Cerebral Metabolism in the Elderly: a Randomised Controlled Trial
Physical activity exerts a variety of long-term health benefits in older adults.This randomised controlled trial investigates the effect of a 12-week physical exercise program on the change in cerebral metabolism as assessed with…
- Trial name
- SMART (NCT02343029)
- Testing
- Individualised aerobic exercise training, Waiting Control
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Professor Johannes Pantel
Heart Failure, Congestive
Heart Failure, Functional and Cognitive Decline, and Psychiatric Symptoms in Nursing Home Patients
Heart failure is very common in the elderly, in whom it may lead to functional and intellectual problems. Functional problems include loss in the ability to perform basic tasks of daily living such as bathing or dressing.
- Trial name
- NCT00182065
- Where
- Canada
- Volunteers
- 586 people
- Sponsor
- McMaster University
Delayed Emergence From Anesthesia, Postoperative Delirium
Trajectory of Recovery in the Elderly
The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who will be evaluated with a…
- Conditions
- Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- TORIE (NCT02275026)
- Testing
- Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Aging, Cognitive Decline
Social and Cognitive Online Training: the SCOT Project
Social isolation and reduced involvement in cognitive activities are associated with repercussions on cognitive well-being and health status in elderly adults.
- Trial name
- SCOT (NCT05023187)
- Testing
- SCOT, CON
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Trento
Aerobic Exercise, Anaerobic Exercise
The Effect of Physical Activity on the Brain
Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the…
- Conditions
- Aerobic Exercise, Anaerobic Exercise, Unchanged Condition
- Trial name
- NCT01475396
- Testing
- exercise
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Mild Cognitive Impairment
Study of the Effects of Adapted Tango and Multidimensional Intervention in pREvention of Dementia in agiNG (STRENGTH)
The STRENGTH project is a randomized controlled trial to assess the effects of a 6 months multimodal intervention consisted of adapted Tango dancing together with music therapy, engagement in social activities, cognitive…
- Trial name
- STRENGTH (NCT04146818)
- Testing
- Adapted Tango Dancing, Control
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Postoperative Cognitive Dysfunction
Evaluation of the Effect of Preoperative Intravenous Amantadine Sulfate on the Postoperative Early Cognitive Functions in a Elderly Patient With Laparoscopic Radical Prostatectomy
Evaluation of the effect of preoperative intravenous administration of amantadine sulfate on the prevention of the development of early cognitive dysfunction in elderly patients undergoing laparoscopic radical prostatectomy
- Trial name
- NCT03988010
- Testing
- Amantadine Sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- TC Erciyes University
Delirium
Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR)
This is a pilot randomized controlled trial that will test whether a multicomponent decision support system will improve the postoperative environment for neurocognitive and clinical recovery in older, high-risk surgical…
- Trial name
- NCT04007523
- Testing
- Family Support System, HELP Support System
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Healthy, Alzheimer Disease
A Study to Measure CSF Proteins in Elderly Healthy Volunteers and Volunteers With Mild Cognitive Impairment or Alzheimer's Disease
The purpose of this study is to investigate changes of cerebral spinal fluid (CSF) proteins over time using continuous CSF sampling for 36 hours in elderly healthy volunteers and volunteers with mild cognitive impairment or…
- Trial name
- NCT01436188
- Testing
- Standard CSR sampling procedure, Alternate frequency CSR sampling procedure, Standard frequent CSR sampling procedure with 800 mg ibuprofen
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Cerebrovascular Disease
Aerobic Dance Training in Small Vessel Disease
Introduction: Cerebral small vessel disease (SVD) is associated with age-related disabilities including dementia, depression, physical and functional impairment. Chinese are more prone to developing SVD than Caucasians.
- Trial name
- ADTSVD (NCT02730065)
- Testing
- Structured Aerobic Dance Training Group, Stretching plus education
- Where
- 2 sites in Hong Kong
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hip Fractures
Early Femoral Block in Elderly With Hip Fracture
Assess if the addition of an early femoral nerve block (performed within 2 hours from the admission in emergency department through a femoral nerve catheter) in the elderly patients (> 70 years) with hip fracture, reduces the…
- Trial name
- NCT03092466
- Testing
- femoral nerve catheter, femoral group, control group
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- ASST Gaetano Pini-CTO
Frail Elderly Syndrome, Mood
FOCUS Guidelines and Adherence to Physical Activity in Ageing Women.
The study aimed at assessing whether the guidelines from the European project FOCUS had an effect on adherence to a physical activity program in older women.
- Conditions
- Frail Elderly Syndrome, Mood, Quality of Life, Cognitive Decline
- Trial name
- NCT03981965
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Delirium in Old Age, Delirium, Postoperative
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction.
- Conditions
- Delirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction
- Trial name
- NCT06817239
- Testing
- Esketamine, Normal saline
- Where
- 6 sites in China
- Volunteers
- 1,670 people
- Sponsor
- Nanfang Hospital, Southern Medical University