Clinical trials: Cognition Function
Dementia
Can Oral Vitamin B12 and Folate Supplementation Preserve Cognitive Function of Patients With Early Dementia?
Background: Vitamin B12 and folate are essential to brain health. Sub optimal status of vitamin B12 and folate leads to elevation of plasma homocysteine concentration, which is associated with Dementia.
- Trial name
- NCT00164970
- Testing
- Vitamin B12, folate
- Where
- China
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Mild Cognitive Impairment, MCI
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
A double-blind, placebo-controlled study that aims to investigate the effect of 2-week and 12-week administration of USP methylene blue (MB) on cerebral blood flow, functional connectivity, memory and attention cognitive…
- Conditions
- Mild Cognitive Impairment, MCI, Aging, Alzheimer's Disease
- Trial name
- MB2 (NCT02380573)
- Testing
- Methylene Blue, FD&C Blue # 2, Phenazopyridine hydrochloride
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Physical Inactivity, Aging
Motivating Activity Through Text Communications - Helping Adults Increase Movement
The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and…
- Conditions
- Physical Inactivity, Aging, Cognitive Ability, Behavior Change
- Trial name
- MATCH AIM (NCT07593677)
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Mellitus, Type 2
Colostrum Supplements Effect on the Physical Performance and Cognitive Function
The goal of this interventional Randomized clinical is to compare the effect of colostrum pharmaceutical preparation and placebo in a sample of Iraqi participants. The main questions to answer are: 1.
- Trial name
- NCT06007430
- Testing
- Colostrum Capsule 500 mg (Colostrum® 500 mg Veg Capsules, nowfoods®, Illinois, USA)
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Al-Mustafa University College
Alteration of Cognitive Function
The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women
Both regular exercise and breakfast consumption have well known health benefits. Consuming breakfast prior to morning exercise may influence appetite, mood and cognitive function later in the day.
- Trial name
- NCT01711008
- Testing
- Cereal, No breakfast
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Type 2 Diabetes Mellitus, Obesity
Type 2 Diabetes and the Brain in Adolescents
This study evaluates differences in brain function and cognitive performance in adolescents with type 2 diabetes (T2D) compared to non diabetic controls (both obese and lean) and correlates these changes with obesity, insulin…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Pediatric Obesity, Insulin Resistance
- Trial name
- NCT03461510
- Testing
- Hyperglycemic clamp, Hyperinsulinemic Euglycemic clamp
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Background of study: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common sequela after SARS-CoV-2 infection(COVID-19). Cognitive dysfunction is one of the most common debilitating symptoms in ME/CFS.
- Trial name
- NCT07357688
- Testing
- Acupuncture
- Where
- 2 sites in China
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Xi Wu
Elderly, Healthy
Agility Training on Physical Performance, Cognitive Function and Brain Activities in Elderly
Agility comprised of cognitive and physical functions, which influences whole-body movement with change of speed and direction. Agility training is widely used in athletes, and recent studies have begun to apply it into the…
- Trial name
- NCT05531396
- Testing
- Agility Training, Health Education
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Blood Pressure
The Effect of Whey Protein Supplementation on Vascular and Cognitive Function in Older Adults
The "hardening of the arteries" observed with aging raises blood pressure and contributes to poor brain blood flow and loss of cognitive function (i.e. attention, memory, solving problems, making decisions).
- Trial name
- NCT01956994
- Testing
- Whey protein supplement, Carbohydrate supplement
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Metabolism - Cerebral Energy
The Efficient Brain Study
Cerebral energy metabolism declines with advanced aging, and is implicated in age-related cognitive decline, Alzheimer's disease (AD), and other forms of neurodegenerative disease (Parkinson's disease).
- Trial name
- NCT02771366
- Testing
- Fermented Papaya Preparation, Granulated Sugar
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Cognitive Dysfunction
Endurance-strength Training in Obese Women
The aim of this study was to compare the effects of three months' endurance training and three months' endurance-strength training on selected psychological aspects in women with abdominal obesity.
- Conditions
- Obesity, Cognitive Dysfunction, Physical Exercise
- Trial name
- PSYCHENDOFIT (NCT04793451)
- Testing
- Endurance training, Endurance-strength training
- Where
- Poland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Aging, Protein Metabolism
Metabolite Changes Following Consumption Of Different Protein Drinks In Singapore Older Adults
The study aims to investigate the acute effects of different protein sources (i.e., casein, whey, soy) on metabolomic profiles (e.g., amino acids in the blood), along with other outcomes such as cognitive function, mood, and…
- Trial name
- NCT06956131
- Testing
- Casein Protein Isolate Drink, Whey Protein Isolate Drink, Soy Protein Isolate Drink
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Mood Behaviour, Cognitive Function
The Impact of Milk-products Differing in Their Glycaemic Properties on the Behaviour of Infants
The current study proposes to investigate the impact of a low glycaemic index (GI), fortified toddlers milkpowder on mood, behaviour and cognitive function in young children.
- Trial name
- NCT01589003
- Testing
- Low Glycaemic index growing up milk, High GI growing up milk
- Where
- Malaysia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Geok Lin Khor
Brain Vascular Function, Cognition
NWT-03 and Brain Function
Age-related chronic diseases including dementia, type II diabetes mellitus (T2DM) and cardiovascular disease (CVD) become more prevalent and of increasing societal concern.
- Trial name
- NCT04831203
- Testing
- An egg-protein hydrolysate (NWT-03)
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome, Coronary Artery Disease
Brain, Cardiac Hemodynamics and Cognition During Exercise in Subjects With Various Cardiovascular Profiles
People with cardiovascular risk (CV) factors (obesity, diabetes, etc...) or established heart disease (such as coronary heart disease or chronic heart failure) often have cognitive dysfunction as compared to people without CV…
- Conditions
- Metabolic Syndrome, Coronary Artery Disease, Heart Failure
- Trial name
- COGNEX (NCT03018561)
- Testing
- Exercise and Cognitive testing
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Metabolic Syndrome, Coronary Heart Disease
Cognition and Exercise Training
The aim of study is to investigate the impact of two different training modalities (high intensity interval training (HIIT) versus moderate intensity continuous exercise training (MICET) on cognitive performance, cerebral…
- Conditions
- Metabolic Syndrome, Coronary Heart Disease, Chronic Heart Failure
- Trial name
- COGNEX-2 (NCT01906957)
- Testing
- high intensity interval training (HIIT), moderate intensity continuous exercise training
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Insomnia
Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia
This study investigates the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia - a population at elevated risk for Alzheimer's disease-related dementias (ADRD)…
- Trial name
- NASC (NCT06694441)
- Testing
- Light Exposure
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Fibromyalgia
A Study To Assess Esreboxetine's Effect On Concentration, Memory, Decision Making And Problem Solving In Patients With Fibromyalgia.
The study is designed to assess if esreboxetine can improve the cognitive function of patients with fibromyalgia. Cognitive function is defined as the ability to concentrate, remember things and make decisions or problem solve.
- Trial name
- NCT00752505
- Testing
- Esreboxetine
- Where
- 7 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Pfizer
Mountain Sickness Acute
Breathing Training to Improve Human Performance at High Altitude
Individuals traveling to altitudes above 8,000 feet may suffer from impaired exercise and cognitive performance, and acute mountain sickness (AMS).
- Trial name
- NCT03530163
- Testing
- Respiratory Muscle Training
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver