Clinical trials: Cognitive/Functional Effects
Cognitive/Functional Effects, Colorectal Cancer
Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer
This randomized phase III trial studies how well combination chemotherapy plus bevacizumab with or without oxaliplatin works in treating older patients with colorectal cancer that has spread to other places in the body.
- Conditions
- Cognitive/Functional Effects, Colorectal Cancer, Neurotoxicity
- Trial name
- NCT01279681
- Testing
- bevacizumab, capecitabine, fluorouracil
- Volunteers
- 32 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Healthy Aging, Cognitive Decline
Cognitively Enriched Walking Program
Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium.
- Conditions
- Healthy Aging, Cognitive Decline, Physical Inactivity
- Trial name
- NCT05500183
- Testing
- Cognitively enriched walking program, walking program
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Ghent
GBM, Depression
The Effect of Escitalopram on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients
Testing the effect of providing an antidepressant and anxiety-type escitalopram for patients with glioblastoma on patient's quality of life including the effect of treatment on mood and cognition during treatment.Two subgroups…
- Trial name
- Cipralex&GBM (NCT02623231)
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Stroke
Cognitive-motor Exercise for Stroke Patients in Function, Cognition and Related Brain Changes.
The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.
- Trial name
- COGMOTION (NCT06362512)
- Testing
- Dual-task training, Single-task training, Upper limb strengthening exercise
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The Hong Kong Polytechnic University
Conditions or Focus of Study: Cognitive Function Loneliness Aging Physical Activity
Wearable-Assisted Walking for Cognitive Function and Loneliness in Older Adults
Participants in the wearable-assisted walking group were asked to walk five days per week for approximately 30 minutes per session at moderate intensity.
- Trial name
- WAW-CogLon (NCT07650292)
- Testing
- Wearable-Assisted Walking Program
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan College of Performing Arts
Cognitive Function, E-sports Performance
Visual Training Effects in Esports Players
This randomized controlled study aims to investigate the acute effects of a single session of web-based visual training on balance, reaction time, and cognitive function in professional e-sports players.
- Conditions
- Cognitive Function, E-sports Performance, Reaction Time, Balance
- Trial name
- NCT07570693
- Testing
- Web-Based Visual Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Schizophrenia Patients
Effect of Ashwagandha as Adjunct Therapy on BDNF and Cognitive Function in Schizophrenia Patients
This study aims to evaluate the effectiveness of Ashwagandha (Withania somnifera) as an adjunctive therapy in improving serum brain-derived neurotrophic factor (BDNF) levels and cognitive function in patients with schizophrenia…
- Trial name
- ASH-BDNF (NCT07541157)
- Testing
- Risperidone 4mg/day, Ashwagandha
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Hasanuddin University
Diabetes Mellitus Type 2
Impact of Dual vs. Single Task Exercise on Cognitive Function, Balance, and Functionality in Type 2 Diabetes
Diabetes Mellitus is defined as a carbohydrate mechanism disorder in which glucose cannot be used as an adequate energy source and is produced excessively, causing hyperglycemia.
- Trial name
- NCT06819371
- Testing
- Single Task Exercise, Dual Task Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Izmir Democracy University
Healthy
Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults
This study is designed to look at the potential for an investigational drug (PF-04995274, under development by Pfizer, Inc. as a potential treatment for Alzheimer's disease) to reverse changes in memory and learning/problem…
- Trial name
- NCT01345864
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Pfizer
Brain Injuries, Traumatic, Confusional State
Multisensory Stimulation and Enriched Environments During Post-traumatic Amnesia
The objective of this Phase II trial is to evaluate the feasibility of this study protocol to progress to a large-scale Phase III RCT in the future.
- Conditions
- Brain Injuries, Traumatic, Confusional State, Sensory Motor System Disorder, Alteration of Cognitive Function
- Trial name
- NCT02792985
- Testing
- Multisensory stimulation protocol, Control protocol
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Institut Guttmann
Healthy Lifestyle, Physical Exercise
Lifestyle and Brain Vascular Function
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function.
- Conditions
- Healthy Lifestyle, Physical Exercise, Healthy Diet, Cerebrovascular Circulation
- Trial name
- NCT04234009
- Testing
- Healthy Lifestyle
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Postoperative Cognitive Dysfunction, Acute Postoperative Pain
Effect of TPVB on Postoperative Pain and Cognitive Function After VATS in Elderly Patients
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block on postoperative acute and chronic pain and cognitive function in elderly patients with thoracoscopic partial lung resection.
- Conditions
- Postoperative Cognitive Dysfunction, Acute Postoperative Pain, Chronic Postsurgical Pain
- Trial name
- NCT05364216
- Testing
- Measurement of cognitive function, Thoracic paravertebral block, The assessment of cognitive function
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Chronic Heart Failure (CHF)
Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction
This study was a multi-center, randomized, double-blind, parallel group, active comparator trial designed to evaluate the overall effect of LCZ696 compared to valsartan on cognitive function as assessed by the CogState…
- Trial name
- PERSPECTIVE (NCT02884206)
- Testing
- LCZ696, Valsartan
- Where
- 135 sites in United States, Argentina and 18 more
- Volunteers
- 592 people
- Sponsor
- Novartis Pharmaceuticals
Placebo - Control, Ketone Monoester
The Effects of Exogenous Ketones on Cognitive Function
The purpose of this study is to evaluate the acute effects of exogenous ketone monoester (KME) supplementation on cognitive function in three groups of adults aged 19-55 years: (1) obese, sedentary individuals; (2) lean…
- Trial name
- NCT07051655
- Testing
- Ketone Monoester (KE)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Exercise, Aerobic Exercise
Acute Effects of Trampoline Exercises
The aim of the study is to investigate the acute effects of trampoline exercises on balance, proprioception, vertical jump and cognitive functions.
- Trial name
- NCT05345535
- Testing
- Trampoline exercise, Walking
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Perioperative Neurocognitive Disorders, Gastric Cancer
Effect of Gastrectomy on Gut Microbiome and Cognitive Function
Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years.
- Trial name
- NCT06186089
- Testing
- probiotics
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Jiangjiang Bi
Schizophrenia
The Effects of Nicotine on Cognition in Schizophrenia
Patients with schizophrenia have a variety cognitive deficits and nicotine has been shown to normalize some of these deficits. The purpose of this study is to investigate the effects of nicotine on cognition in schizophrenia.We…
- Trial name
- NCT00383747
- Testing
- transdermal nicotine patch
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Chronic Obstructive Pulmonary Disease COPD
Pulmonary Rehabilitation: Effects on Cognitive Functioning, Mood, Anxiety, and Quality of Life in Patients With COPD
The purpose of this project is to investigate whether a 12-week, fulltime pulmonary rehabilitation program can enhance cognitive functioning, mood, anxiety, and quality of life in patients with Chronic Obstructive Pulmonary…
- Trial name
- NCT01682447
- Testing
- Extensive Pulmonary Rehabilitation Program
- Where
- Netherlands
- Volunteers
- 261 people
- Sponsor
- Tilburg University
Cognitive Function
The Effect of Transcutaneous Vagus Nerve Stimulation on Cognitive Function
Cognitive health is generally considered a key component of quality of life. Current evidence indicates that a large number of individuals are at a high risk for cognitive impairment from many causes as they age.
- Trial name
- NCT04070547
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- Czechia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ostrava
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
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