Clinical trials: Cognitive
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Aggression, Anger
Group CBT for Aggression in Veterans
Posttraumatic stress disorder (PTSD) robustly predicts anger and aggression, and U.S. Iraq/Afghanistan-era combat Veterans report that treatment for anger and aggression is among their top priorities.
- Conditions
- Aggression, Anger, Posttraumatic Stress Disorder
- Trial name
- CBT-A (NCT02233517)
- Testing
- Cognitive Behavioral Therapy, Present Centered Therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Post Traumatic Stress Disorder
Cognitive-Behavioral Conjoint Therapy (CBCT) Project
Untreated posttraumatic stress disorder (PTSD) is a costly condition associated with impairment in functioning across a host of psychosocial domains including occupational and academic functioning, marital and family functioning…
- Trial name
- CBCT (NCT02720016)
- Testing
- CBCT-Home Based (CBCT-HB), CBCT-Office Based (CBCT-OB), PTSD Family Education (PFE)
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- VA Office of Research and Development
Transcranial Direct Current Stimulation, Smoking, Cigarette
tDCS and Cognitive Training Intervention for Chronic Smokers With Schizophrenia
This study is being done to develop new methods to help smokers with schizophrenia to successfully reduce their smoking and/or quit. This is not a treatment study, but will help find new techniques to create better treatments.
- Conditions
- Transcranial Direct Current Stimulation, Smoking, Cigarette, Schizophrenia
- Trial name
- TACTICSS (NCT03588728)
- Testing
- Transcranial Direct Current Stimulation, Cognitive Remediation (CR)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Pittsburgh
Executive Function
The Effect of Acute Concurrent Exercise on Executive Function: An Event-Related Potential Study
Executive function is a high-level cognition which plays an important role in our life. Meta-analysis study has demonstrated that acute exercise could improve executive function.
- Trial name
- NCT05314634
- Testing
- concurrent exercise, aerobic exercise
- Where
- Taiwan
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Mild Cognitive Impairment
Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment
Emerging evidence indicates that dysfunction of hippocampal synaptic plasticity, which precedes neuronal degeneration during the progression of Alzheimer's disease (AD), underlies the hallmark cognitive impairment.
- Trial name
- TMS-fMRI (NCT05515952)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arizona
Chemo Brain, Chemotherapy-related Cognitive Impairment
Nicotinic Treatment of Post-Chemotherapy Subjective Cognitive Impairment: A Pilot Study
The purpose of this study is to evaluate the use of a nicotine patch as a treatment for problems with attention, learning and memory in breast cancer patients who are 1-5 years post chemotherapy.
- Conditions
- Chemo Brain, Chemotherapy-related Cognitive Impairment, Chemo Fog, Breast Cancer
- Trial name
- NCT02312934
- Testing
- Transdermal nicotine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University Medical Center
Driving Performance, Cognitive Impairment
The Effects of Cannabidiol on the Driving Ability of Healthy Adults
A randomized, parallel-group, double-blind, exploratory two-arm trial to assess the effects of CBD on driving ability along with changes in psychological status (i.e. mood, drowsiness, sedation) and cognitive function.
- Conditions
- Driving Performance, Cognitive Impairment, Sedation Complication, Mood
- Trial name
- NCT04590495
- Testing
- 300 mg Cannabidiol (CBD) oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Age-related Cognitive Decline
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
The purpose of this research study is to examine the potential benefits of vortioxetine in combination with at-home computerized cognitive training program to improve cognition, such as memory, attention, and concentration.
- Trial name
- BBS (NCT03272711)
- Testing
- Vortioxetine 10 mg, Cognitive training program
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Huntington's Disease
Randomized, Placebo Controlled Study Of The Efficacy And Safety Of PF-02545920 In Subjects With Huntington's Disease
This study is a 26 week, randomized, parallel group, double blind comparison of PF-02545920 5 mg, PF-02545920 20 mg, and placebo dosed BID in the treatment of motor impairment of subjects with Huntington's Disease.
- Trial name
- NCT02197130
- Testing
- PF-02545920
- Where
- 57 sites in United States, Canada and 3 more
- Volunteers
- 272 people
- Sponsor
- Pfizer
Healthy, Alzheimer's Disease
A Study of LY2599666 in Healthy Participants and Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD)
The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY2599666 in different groups of people - those who are healthy, those who have mild cognitive impairment due to Alzheimer's…
- Conditions
- Healthy, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT02614131
- Testing
- LY2599666, Solanezumab
- Where
- 5 sites in United States, Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Mild Cognitive Impairment
Consumption of Potatoes, Avocados and Chickpeas and Cognitive Function in Older Adults
Cognitive impairment is also a major risk factor for development of dementia later in life. Findings from the investigators studies suggest that the carotenoids, lutein and zeaxanthin may be important in cognitive function in the…
- Trial name
- NCT01620567
- Testing
- avocado, potato or chickpea
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tufts University
Mild Cognitive Impairment, MCI
Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease
A double-blind, placebo-controlled study that aims to investigate the effect of 2-week and 12-week administration of USP methylene blue (MB) on cerebral blood flow, functional connectivity, memory and attention cognitive…
- Conditions
- Mild Cognitive Impairment, MCI, Aging, Alzheimer's Disease
- Trial name
- MB2 (NCT02380573)
- Testing
- Methylene Blue, FD&C Blue # 2, Phenazopyridine hydrochloride
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Post-traumatic Stress Disorder, Stress Disorders
Effectiveness of Cognitive Processing Therapy in Pregnant Women With a History of Pregnancy Loss/Complication
The purpose of this study is to examine the effects of experiencing a previous pregnancy loss or complication on current physiological and emotional aspects of a current pregnancy.
- Conditions
- Post-traumatic Stress Disorder, Stress Disorders, Anxiety, Depression
- Trial name
- NCT01277354
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Cognitive Behavioral Therapy, Autism Spectrum Disorder
Parent-Led Cognitive-Behavioral Teletherapy for Anxiety in Youth With ASD
This study implements an anxiety-focused, parent-led, therapist-assisted cognitive behavioral teletherapy for parents of youth with ASD and anxiety.
- Conditions
- Cognitive Behavioral Therapy, Autism Spectrum Disorder, Anxiety Disorders, Obsessive-Compulsive Disorder
- Trial name
- NCT04111874
- Testing
- Cognitive Behavioral Teletherapy LTA, Cognitive Behavioral Teletherapy STA
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Baylor College of Medicine
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Substance Use Disorders
Guanfacine to Improve Substance Use Outcomes in Women
Hypothesis: Guanfacine (GUA) (3mg/day) will reduce drug craving, improve cognitive flexibility and result in associated lower drug use in women with substance use disorder (SUD) in an outpatient clinical setting.
- Trial name
- NCT03980184
- Testing
- Guanfacine, Behavioral Counseling
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Yale University
Schizophrenia
Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia
This study will examine whether pretreatment with D-cycloserine before cognitive behavioral therapy can reduce impairments still present in people with stable cases of schizophrenia as well as determine which traits make…
- Trial name
- NCT00742079
- Testing
- D-cycloserine, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital