Clinical trials: Cognitive Aging
Healthy Aging, Cognitive Decline
Cognitively Enriched Walking Program
Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium.
- Conditions
- Healthy Aging, Cognitive Decline, Physical Inactivity
- Trial name
- NCT05500183
- Testing
- Cognitively enriched walking program, walking program
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Ghent
Conditions or Focus of Study: Cognitive Function Loneliness Aging Physical Activity
Wearable-Assisted Walking for Cognitive Function and Loneliness in Older Adults
Participants in the wearable-assisted walking group were asked to walk five days per week for approximately 30 minutes per session at moderate intensity.
- Trial name
- WAW-CogLon (NCT07650292)
- Testing
- Wearable-Assisted Walking Program
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan College of Performing Arts
Mild to Heavy Alcohol Consumption
Cognitive, Behavioral and Aging Effects of Pain Medication in Alcohol Users
The purpose of this study is to examine the relationship between heavy alcohol use, pain, and response to pain medication in older adults.
- Trial name
- CAAP (NCT02945293)
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Washington
Aging, Cognitive Dysfunction
Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1
The investigators are conducting a cross-sectional, observational study to investigate whether plasma GPLD1 concentrations are associated with higher cognitive function and better brain structure and function in two groups of…
- Trial name
- BrainFit (NCT04645134)
- Testing
- Brain Health Assessments
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Alzheimer Disease, Mild Cognitive Impairment
Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
This study seeks to better understand how older adult aging-in-place/long term care decision making and implementation is impacted by age-related changes (e.g.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Long-Term Care Planning
- Trial name
- PYL (NCT03960476)
- Testing
- PlanYourLifespan.org
- Where
- United States
- Volunteers
- 293 people
- Sponsor
- Northwestern University
Serious Mental Illness, Older Adults
A Pilot Randomized Controlled Trial of the Hopeful and Healthy Living Program
The goal of this clinical trial is to learn if a novel psychosocial intervention is effective in helping adults over 50 with serious mental illness (SMI) increase their social connections and participate in more healthy lifestyle…
- Trial name
- (HHL) (NCT06940843)
- Testing
- Hopeful and Healthy Living (HHL)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise
Aging, Mild Cognitive Impairment
Application of the Modified Story Memory Technique (mSMT)© to Aging
This study is a double-blind placebo-controlled randomized clinical trial (RCT) to provide Class I evidence in support of or in refute of the efficacy of the modified Story Memory Technique (mSMT) in healthy aging (HA)and in…
- Trial name
- NCT03370224
- Testing
- Memory retraining exercises
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Cognitive Decline, Aging
Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults
This prospective observational study aims to investigate the effects of a multidomain community-based support program on cognitive function and quality of life in older adults attending the Vefahane Life Center in Istanbul…
- Conditions
- Cognitive Decline, Aging, Quality of Life
- Trial name
- NCT07610109
- Testing
- Multidomain Community Support Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Functional Aging, Subjective Cognitive Concerns
A Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia
This intervention is designed to promote enhanced use of compensation strategies including calendar and task list use, and organization systems, as well as increased engagement with brain health activities including physical…
- Conditions
- Functional Aging, Subjective Cognitive Concerns, Compensation Strategies, Brain Health Activities
- Trial name
- NCT03549078
- Testing
- Intervention
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cognitive Reserve, Aging
Cognitive Reserve and Post-Fatigue Recovery in Older Adults
As people grow older, it is common to experience a drop in physical stamina and memory functions. This can make recovering from daily physical and mental fatigue more difficult, which directly impacts an individual's independent…
- Conditions
- Cognitive Reserve, Aging, Mental Fatigue, Fatigue
- Trial name
- NCT07667985
- Where
- Turkey (Türkiye)
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- Uşak University
Occupational Therapy, Nursing Caries
Spanish Adaptation and Validation of the Everyday Cognition Battery (ECB).
HYPOTHESIS: The Spanish version of the Everyday Cognition Battery Scale (ECB) is valid and reliable in the Spanish population. OBJECTIVES: Providing a validated scale in Spanish to evaluate daily cognition in older adults.
- Conditions
- Occupational Therapy, Nursing Caries, Aging Disorder, Cognitive Disorders
- Trial name
- NCT04169633
- Testing
- Cognitive Function Evaluation
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Age-related Cognitive Decline
Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB
This study aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program (PACR-CT) five years from the initial 10 weeks of training from our Phase II study …
- Trial name
- BETTER Aging (NCT05599490)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training
- Where
- 2 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Mild Cognitive Impairment, NAD
The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
The purpose of this study is to determine the effects of Niagen (nicotinamide riboside, vitamin B3), on NAD levels, brain function including cognition and blood flow in people diagnosed with mild cognitive impairment (MCI).
- Trial name
- NAD (NCT02942888)
- Testing
- Nicotinamide riboside, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cognitive Dysfunction, Cognitive Disorder, Dietary Supplements
INSIDE: Intervention in Nutritional Supplementation to Improve Cognitive Decline in Elderly.
This study investigates the effect of nutritional supplementation on cognitive performance in older adults over a 90-day period using a double-blind randomized controlled design.
- Trial name
- INSIDE (NCT07000500)
- Testing
- Nutritional Supplement
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Maria Paço
Healthy
Optimizing Combined Physical and Cognitive Activity in Community-Dwelling Older Adults.
This laboratory-based interventional study aims to determine which combination of physical activity intensity and cognitive activity difficulty yields the greatest acute cognitive benefits in community-dwelling older adults.
- Trial name
- CONSCIOUS (NCT07630272)
- Testing
- Light physical activity + easy cognitive activity, Light physical activity + challenging cognitive activity, Moderate physical activity + easy cognitive activity
- Where
- Belgium
- Volunteers
- 53 people
- Sponsor
- University Ghent
Expectation Effects on Emotional Processing in Late Life
Expectation Effects on Emotional Processing in Late Life
Understanding the mechanisms of expectation effects in the affective system is vital, given high placebo rates in antidepressants. Evidence has consistently confirmed that expectations can influence our emotional experience.
- Trial name
- NCT06251284
- Testing
- Saline nasal spray
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mild Cognitive Impairment
Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2
The goal of this Stage 1 (NIH Stage Model) Intervention Development cross-site project is to develop, using a user-centered design approach, and evaluate an innovative intelligent adaptive software package aimed at providing…
- Trial name
- NCT07485712
- Testing
- Project 2, Phase 2: Intelligent Adaptive System
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Aging
The Effect of NAD Supplementation on Brain Vascular Health in Aging
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
- Trial name
- NCT05483465
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Mild Cognitive Impairment, Subjective Memory Impairment
The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
There is a dearth of research which takes a multi-compound approach to dietary interventions, in humans, aimed at improving outcome measures of cognition.
- Trial name
- CANN (NCT02525198)
- Testing
- fatty acid/flavonoid blend
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University of East Anglia