Clinical trials: Cognitive Aids
HIV
Improving Memory Performance by Applying Cognitive Training
The proposed study will test the efficacy of a cognitive training program to improve working memory in a sample of HIV-infected persons.
- Trial name
- IMPACT (NCT02216591)
- Testing
- Active Cognitive Training (ACT), Control (CON)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Opioid Dependence, Hepatitis
Computer-based Cognitive Behavioral Therapy for Risky Behaviors in Opioid Dependent Patients
The purpose of this study is to determine if a computerized version of Cognitive Behavioral Therapy (CBT) can improve high-risk sexual behaviors in patients attending an outpatient methadone treatment clinic.
- Conditions
- Opioid Dependence, Hepatitis, HIV
- Trial name
- NCT01645033
- Testing
- computerized Cognitive Behavioral Therapy (CBT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Smoking Cessation
Cognition and Smoking Relapse (HCS)
This study tests whether withdrawal-related cognitive deficits increase smoking relapse among HIV-infected (HIV+) vs. HIV-uninfected smokers (HIV-).
- Trial name
- HCS (NCT03169101)
- Testing
- Nicotine patch, Behavioral counseling
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- University of Pennsylvania
HIV-Dementia, HIV-Associated Cognitive Motor Complex
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)
The purpose of this protocol is to measure a receptor in the brain using positron emission tomography (PET) that is involved in inflammation.
- Conditions
- HIV-Dementia, HIV-Associated Cognitive Motor Complex, AIDS Encephalopathy, AIDS Dementia Complex
- Trial name
- NCT00459693
- Testing
- [11C]PBR28
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognitive Dysfunction
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
The goal of this pilot work was to determine if the cognitive dysfunction accommodation strategies help patients retain/utilize more HIV prevention information and increase PrEP adherence.
- Trial name
- NCT05912374
- Testing
- standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB), enhanced Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
HIV, Depression
Treatment for Depression Among HIV-Infected Youth
This is a two-phase study that is designed to test a novel behavioral intervention to treat depression in Human Immunodeficiency Virus (HIV) adolescents and young adults.
- Conditions
- HIV, Depression, HIV Infections
- Trial name
- NCT01049789
- Testing
- COMB - Combination Cognitive Behavioral Therapy and Medication Management, TAU - Treatment as Usual
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Medication Adherence, Methamphetamine Use
Intervention Targeting Medication Adherence and Methamphetamine Use in HIV Positive Men (ACE)
The primary aim is to test an innovative 8-session intervention, based on Motivational Interviewing and Cognitive Behavioral Skills-Training for the co-occurrence of methamphetamine use and highly active antiretroviral therapy…
- Conditions
- HIV Medication Adherence, Methamphetamine Use, Sexual Risk, Poly-substance Use
- Trial name
- ACE (NCT01122186)
- Testing
- Motivational Interviewing + Cognitive Behavioral Skills Training, Education Attention Control
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Hunter College of City University of New York
Binge Drinking, Alcohol Abuse
Cognitive Behavioral Treatment to Reduce Alcohol Use Among HIV-Infected Kenyans
This study will determine whether a cognitive behavioral intervention that demonstrates strong evidence in the U.S. of reducing alcohol use is effective when delivered by paraprofessionals in Kenya and compared against a usual…
- Conditions
- Binge Drinking, Alcohol Abuse, Alcohol Dependence, HIV Infections
- Trial name
- KHBS (NCT00792519)
- Testing
- HIV support group, CBT
- Where
- Kenya
- Volunteers
- 75 people
- Sponsor
- Brown University
HIV, PrEP
The ACT-PrEP Study
AIM: To evaluate the integration of point-of-care etiological STI testing, cognitive behavioral counselling (CBC), and sexual partner engagement strategies to improve STI management, PrEP uptake and 3-month PrEP persistence among…
- Conditions
- HIV, PrEP, Acceptability, Appropriateness
- Trial name
- NCT07867990
- Testing
- POC STI testing, CBC, and partner self-testing to improve PrEP uptake and persistence among pregnant and postpartum women., Standard of Care
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
HIV Seropositivity, ART
Effects of VSL#3 on Neuro-cognitive Profile of HIV Patients
Aim of the study is to evaluate the effects of a change in the intestinal microflora on the neuro-cognitive profile of patients with HIV infection receiving HAART treatment.
- Trial name
- NCT02276326
- Testing
- VSL#3 sachets
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Policlinico Umberto I
Quality of Life, Anxiety
CBT and Quality of Life of People With HIV, COVID-19 and Anxiety or Depression
Experimental open-label randomized clinical trial to determine the effect of virtual Cognitive Behavioral Therapy (CBT) on the quality of life of patients with HIV, COVID-19 and anxiety or depression.
- Conditions
- Quality of Life, Anxiety, Depression
- Trial name
- COVIHMENT-19 (NCT05185921)
- Testing
- Trial-based Cognitive therapy
- Where
- Peru
- Volunteers
- 182 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Age-related Hearing Loss, Age-related Cognitive Decline
Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL
This study intends to retrospectively collect and analyze the case data of patients with age-related hearing loss who were admitted to the Otolaryngology Department of Sun Yat-sen Memorial Hospital from January 2020 to June 2024.
- Conditions
- Age-related Hearing Loss, Age-related Cognitive Decline, Depression, Sleep Disturbance
- Trial name
- EEG/ARHL (NCT06893432)
- Testing
- hearing aids
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
HIV
Does Micro-albuminuria is a Predictive Factor for Cognitive Impairment in Persons Living With HIV (PLHIV) Who Achieve cART-sustained Immunovirological Control ?
Chronic kidney disease (CKD), frequent in PLHIV, is a risk factor for cognitive impairment. Micro-albuminuria is an early manifestation of CKD and a marker of vascular risk, notably affecting the small vessels.
- Trial name
- ALCOVE (NCT02852772)
- Testing
- Cognitive function tests
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hepatitis C, Depressive Disorder, Major
Prevention of Depression in HIV/HCV Co-infected Substance Abuse Patients
The purpose of this study is to determine whether cognitive behavioral therapy (CBT) is effective in the prevention of depression during interferon and ribavirin treatment for hepatitis C infection.
- Conditions
- Hepatitis C, Depressive Disorder, Major, Depressive Disorder, Depression
- Trial name
- NCT00655226
- Testing
- Hepatitis C educational support groups, Cognitive Behavioral Therapy skills based group sessions
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
HIV Medication Adherence in Underserved Populations
The purpose of this study is to determine whether cognitive rehabilitation or psychoeducation impacts medication adherence in HIV-1 seropositive individuals.
- Trial name
- NCT02392884
- Testing
- Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
HIV Infections, Cognitive Impairment
Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV
People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity.
- Trial name
- HEALTH-COG (NCT06013579)
- Testing
- Phase 1 Gym Exercise HIIT, Phase 1 Gym Exercise CME, Phase 2 Home Exercise Coaching Text Messages
- Where
- 3 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
PTSD, Hiv
CPT-L to Improve Outcomes for Individuals With HIV and PTSD
This study plans to adapt and examine the acceptability and feasibility of an evidence-based PTSD treatment that has reduced other HIV transmission behavior (e.g., sexual risk), Cognitive Processing Therapy (CPT), at an HIV…
- Trial name
- NCT05275842
- Testing
- Cognitive Processing Therapy- Lifesteps (CPT-L), Lifesteps
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Medical University of South Carolina
Parkinson Disease
Pilot Study to Determine if Working Memory Training Aids Cognitive Functioning in Patients With Parkinson's Disease
This project will investigate the feasibility and preliminary effectiveness of an intensive and focused working memory training program for patients in the early stages of PD receiving dopaminergic therapy.
- Trial name
- PDWM (NCT01647698)
- Testing
- Adaptive working memory training task, Non-adaptive working memory training task (i.e. an active control task), No training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Gail Eskes
HIV-1-infection, Unhealthy Alcohol Use
IGHID 12230 - An Implementation Trial of an Experiential Brief Alcohol Intervention for HIV Prevention
This study is a hybrid type 3, cluster randomized implementation trial to examine effective strategies to scale up the Brief Alcohol Intervention (BAI) in ART clinics in Vietnam.
- Trial name
- EBAI (NCT06358885)
- Testing
- Facilitation (FAC), Experiential Brief Alcohol Intervention (EBAI)
- Where
- Vietnam
- Volunteers
- 3,234 people
- Sponsor
- University of North Carolina, Chapel Hill
Human Immunodeficiency Virus (HIV), HIV Associated Neurocognitive Disorders (HAND)
A Study of the Neurological Effects of Adding Maraviroc to HAART Regimen in Patients With HIV (HANDmac)
HIV related cognitive impairment still occurs despite highly active antiretroviral therapy (HAART). HIV disease affects the brain in 20-40% of patients with advancing HIV disease; leading to varying degrees of cognitive…
- Trial name
- HANDmac (NCT01449006)
- Testing
- Maraviroc
- Where
- 2 sites in Australia
- Volunteers
- 19 people
- Sponsor
- Bruce Brew