Clinical trials: Cognitive Behavioral Therapy
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorders
Cognitive Behavioral Therapy to Improve Work and Wellness in Veterans With Mental Illness
Vocational instability in Veterans with serious mental illness (SMI) is pervasive, costly, and harmful. Over 75% of Veterans with SMI are unemployed, resulting in economic difficulties and trouble meeting basic needs.
- Trial name
- WORKWELL (NCT04504903)
- Testing
- Cognitive Behavioral Therapy For Work Success (CBTw), Psychoeducation
- Where
- 3 sites in United States
- Volunteers
- 294 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder
Psilocybin-assisted CBT for Depression
The primary objectives of this clinical investigation are to (1) determine the acceptability and feasibility of joining psilocybin-assisted therapy with cognitive-behavioral therapy (PA-CBT) for patients with depression, (2)…
- Trial name
- NCT05227612
- Testing
- Psilocybin, Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, Los Angeles
Adolescents, Mood Disorders
Mobile-enhanced Group CBT for Adolescents at Risk Severe Mood Disorders
Although cognitive-behavioral therapy (CBT) has shown efficacy in reducing symptoms and rates of mood relapse in adolescents at high risk for severe mood disorders (SMD; i.e., bipolar I/II disorder and recurrent or unremitting…
- Trial name
- NCT04887155
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of California, Los Angeles
Depression
Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological Disorder
Prospective, multicenter, non-comparative, observational program to describe prevalence of depressive symptoms in a variety of neurological disorders and effects of Fevarin® on the severity of anxiety and depression, sleep state…
- Trial name
- FRIENDS (NCT02043197)
- Where
- 29 sites in Russia
- Volunteers
- 300 people
- Sponsor
- Abbott
Breast Cancer, Depression
Intervention Study of Depression in Breast Cancer Patients
The purpose of this study is to evaluate the efficacy of cognitive-behavioral therapy on depression and anxiety in breast cancer patients.
- Conditions
- Breast Cancer, Depression, Anxiety
- Trial name
- NCT01256008
- Testing
- CBT, Clinical Management
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Wenzhou Medical University
Gulf War Illness, Insomnia
Cognitive Behavioral Therapy for Insomnia for Gulf War Illness
Sleep disturbance is a common complaint of Veterans with Gulf War Illness (GWI). Because there is clinical evidence that sleep quality influences pain, fatigue, mood, cognition, and daily functioning, this study will investigate…
- Trial name
- CBTi GWI (NCT02782780)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBTi)
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- VA Office of Research and Development
Adherence, Treatment
Smart Reminders to Promote Home-based Cognitive Training
This study will examine whether among older adults an adaptive and personalized reminder system can better support adherence to home-based cognitive training over typical reminder systems.
- Trial name
- NCT05016856
- Testing
- Adherence Promotion With Person-centered Technology (APPT) System, Standard Reminder System (Active Control)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Florida State University
Depressive Disorder, Major
Mindfulness Based Cognitive Therapy for Recurrent Depression
The purpose of this study is to investigate the effectiveness and possible mediating factors of Mindfulness Based Cognitive Therapy (MBCT) for recurrent depression.
- Trial name
- NCT01038765
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Radboud University Medical Center
Posttraumatic Stress Disorders, PTSD
Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth
The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT plus placebo to reduce symptoms of posttraumatic stress disorder (PTSD) in 7-12 year old…
- Trial name
- NCT01157416
- Testing
- D-cycloserine, CBT
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Tulane University School of Medicine
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Cystitis, Interstitial, Painful Bladder Syndrome
- Trial name
- NCT04275297
- Testing
- Psychosocial Treatment, Attention Control
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University Medical Center
Depression, Traumatic Brain Injury
Mindfulness-Based Cognitive Therapy Intervention to Treat Depression in Individuals With a Traumatic Brain Injury
The purpose of this study is to determine whether mindfulness-based cognitive therapy is effective in reducing depression symptoms in individuals who have experienced a traumatic brain injury.
- Trial name
- NCT00745940
- Testing
- MBCT for TBI
- Where
- 3 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Lakehead University
Stress Disorder, Post Traumatic
D-cycloserine and Virtual Reality Exposure to Treat Iraq War Veterans With PTSD
This study will determine whether a combination of virtual reality exposure therapy and D-cycloserine will reduce post-traumatic stress disorder symptoms in Iraq war veterans.
- Trial name
- NCT00356278
- Testing
- D-Cycloserine, Alprazolam, Virtual Reality Exposure Therapy
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Emory University
Inflammation, Fatigue
Effects of Riluzole on CNS Glutamate and Fatigue in Breast Cancer Survivors With High Inflammation
The goal of the proposed research is to determine whether riluzole, a drug that increases glutamate reuptake, will decrease central nervous system (CNS) glutamate in breast cancer survivors with increased inflammation and…
- Trial name
- NCT02796755
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Posttraumatic Stress Disorder, Depression
Loving-Kindness Meditation for PTSD
This randomized controlled trial will assess whether a novel complementary and alternative medicines (CAM) intervention, Loving-kindness Meditation (LKM), is not meaningfully inferior to another group-based PTSD treatment …
- Trial name
- NCT01962714
- Testing
- Loving-Kindness Meditation, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Major Depression, Treatment
fMRI Study of Treatment Changes in Major Depression
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy…
- Trial name
- NCT01027559
- Testing
- Sertraline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Body Dysmorphic Disorder
Cognitive Behaviour Therapy (CBT) for Body Dysmorphic Disorder (BDD)
The aim of the research is to determine if Cognitive Behaviour Therapy (CBT) specific for BDD is more effective than a credible non-specific form of CBT for treating BDD and its delusional variant in adults aged 17 or over.
- Trial name
- NCT00871143
- Testing
- CBT specific for BDD, Non specific CBT
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- Institute of Psychiatry, London
Complex Insomnia
Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD
Obstructive sleep apnea (OSA) is commonly reported in Veterans with post-traumatic stress disorder, which can potentiate symptoms of anxiety and depression, daytime symptoms and worsen nightmares.
- Trial name
- PRECEPT-D (NCT03937713)
- Testing
- eszopiclone, Brief behavioral therapy for insomnia
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Chronic Musculoskeletal Pain
Implementation of Nurse-guided Web-based Cognitive Behavioral Therapy for Pain Management
To see if nurse guided web based cognitive behavioral therapy (CBT) will show pain improvement in patients with all types of pain complaints.
- Trial name
- NCT03927846
- Testing
- Nurse-guided Web-based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Schizoaffective Disorder
A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder
Varenicline (Chantix) is a smoking cessation treatment that was approved in 2006 by the FDA for treatment of nicotine dependence and may be particularly beneficial in smokers with schizophrenia or bipolar disorder.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Smoking
- Trial name
- SCRP (NCT00621777)
- Testing
- Varenicline
- Where
- 10 sites in United States
- Volunteers
- 247 people
- Sponsor
- Massachusetts General Hospital