Clinical trials: Cognitive Change, open to volunteers
Chronic Cancer-related Pain
An N-of-1 Trial of an Internet-delivered CBT Program Based on the Psychological Flexibility Model of Chronic Pain for Cancer-related Difficulties
Chronic pain is a commonly occurring complication of cancer and can have negatively impact day-to-day functioning and well-being. The recommended treatment for all forms of chronic pain is cognitive behavioral therapy (CBT).
- Trial name
- NCT06749964
- Testing
- Internet-delivered, therapist-assisted, pain-focused CBT based on the psychological flexibility model for chronic pain
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University
Impaired Cognition, Chemo-brain
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
- Conditions
- Impaired Cognition, Chemo-brain, Breast Cancer
- Trial name
- NCT02290834
- Testing
- Cognitive, functional and subjective assessments, MRI, PET Scan
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue
A Clinical Trial to Evaluate the Effects of Adrenal Adapt on Sleep Quality, Daytime Energy, Stress Resilience, and Cognitive Performance.
This is a single-group, open-label, uncontrolled clinical trial designed to evaluate the effects of Adrenal Adapt, a commercially available dietary supplement, on sleep quality, daytime energy, stress resilience, and cognitive…
- Conditions
- Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue, Improves Overall Sleep Quality and Restorative Sleep, Helps People Fall Asleep Faster and Wake Less During the Night
- Trial name
- NCT07893561
- Testing
- Adrenal Adapt
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioligent
Neck Pain, Chronic Neck Pain
Effects of Different Exercise Protocols on Physical and Cognitive Changes in People With Chronic Neck Pain
This study aims to investigate the effects of different exercise approaches on physical status, cognitive functions, brain structures, and blood biomarkers in individuals with chronic neck pain.
- Trial name
- NCT07432425
- Testing
- Aerobic exercise, Strengthening exercise, Posture and strentching exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Hacettepe University
Fetal Growth Abnormalities, Fetal Weight
Impact of AI Feedback on Ultrasound Biometry Accuracy Across the Expertise Levels
Objective: To evaluate the impact of real-time AI feedback on fetal biometry accuracy and investigate the Expertise Reversal Effect-whether AI benefits diminish as user experience increases.
- Trial name
- NCT07476638
- Testing
- AI interventional group
- Where
- 3 sites in Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Autism Spectrum Disorder (ASD), Anxiety
Adapted Group Therapy Compared With Usual Care for Anxiety and Depression in Adults With an Autism Diagnosis
The goal of this clinical trial is to learn whether an adapted group therapy works to treat anxiety and depression in adults with an autism diagnosis. The therapy is a form of cognitive behavioral therapy (CBT).
- Conditions
- Autism Spectrum Disorder (ASD), Anxiety, Depression
- Trial name
- CoMind (NCT07880028)
- Testing
- Autism-adapted group cognitive behavioral therapy
- Volunteers
- 154 people
- Sponsor
- Lovisenberg Diakonale Hospital
Cognitive Change
COgnitive Dynamics in Early Childhood
The goal of this accelerated longitudinal observational cohort study is to advance our understanding of cognitive variability in children aged 7 to 10 at first measurement.
- Trial name
- CODEC (NCT06330090)
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Aging, Alzheimer Disease
Exercise to Improve Brain Health in Older African Americans
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.
- Conditions
- Aging, Alzheimer Disease, Healthy Aging, Cognitive Change
- Trial name
- NCT05597124
- Testing
- Cardio-Dance Fitness, Strength, Flexibility & Balance
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Subjective Cognitive Decline (SCD), Olfactory Dysfunction
The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can delay the progression of MCI in older…
- Conditions
- Subjective Cognitive Decline (SCD), Olfactory Dysfunction, Mild Cognitive Impairment (MCI), ELDERLY PEOPLE
- Trial name
- NCT06821828
- Testing
- Modified olfactory training device, Conventional olfactory training device
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
ICU Delirium
Modified Hospital Elder Life Program at Intensive Care Unit
Delirium, a form of acute brain dysfunction, occurs in up to 81% of patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- mHelp@ICU (NCT06054828)
- Testing
- mHELP@ICU
- Where
- Taiwan
- Volunteers
- 266 people
- Sponsor
- National Taiwan University Hospital
Cognitive Change
Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals
Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations.
- Trial name
- NCT05303428
- Testing
- Neuromodulation with low-intensity focused ultrasound
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Occupational Health, Sleep
Using Cognitive-Behavioral Change and Mobile Technology to Improve RN Sleep and Fatigue
The U.S. registered nurse (RN) workforce is the largest in the Healthcare and Social Assistance Sector and is at high risk for injuries and errors due to poor sleep and fatigue.
- Conditions
- Occupational Health, Sleep, Fatigue, Nurse
- Trial name
- RN-SLEEP (NCT06105307)
- Testing
- RN-SLEEP, Healthy Habit - Educational Control
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Multiple Sclerosis, Cognitive Change
Remote Evaluation of MIND Diet
The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in…
- Conditions
- Multiple Sclerosis, Cognitive Change, Nutrition, Healthy
- Trial name
- REMIND (NCT06450977)
- Testing
- MIND Diet, Control Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Illinois at Urbana-Champaign
Age-related Hearing Loss, Hearing Loss, Sensorineural
A Prospective Cohort Study On Change of Cognitive Function In Aged-related Hearing Loss With Hearing Aids
Background: Deafness is one of the nine potentially modifiable risk factors for dementia simulated by the Lancet dementia Prevention, intervention and Care Committee in 2017.
- Conditions
- Age-related Hearing Loss, Hearing Loss, Sensorineural, Hearing Aid, Cognitive Function Abnormal
- Trial name
- NCT05694039
- Testing
- Hearing Aids
- Where
- China
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sickle Cell Disease, Cognitive Impairment
Minocycline In Neurocognitive Outcomes - Sickle Cell Disease
Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications.
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- MINO-SCD (NCT05605366)
- Testing
- Minocycline
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Motor-Cognitive Function, Dual-Task Walking
Effects of Adapted Argentine Tango Training Frequency on Dual-Task Walking
This randomized controlled trial will examine whether the frequency of adapted Argentine tango training affects walking and cognitive function in adults aged 55 to 60 years when the total weekly intervention time is kept the…
- Conditions
- Motor-Cognitive Function, Dual-Task Walking, Balance
- Trial name
- AAT-FREQ (NCT07800494)
- Testing
- Distributed Adapted Argentine Tango Training, Concentrated Adapted Argentine Tango Training, Health Education and Low-Intensity Stretching
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Xi'an Medical University
Lymphoma Receiving CAR-T Therapy
Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy
The purpose of this study is to learn about possible changes in cognitive (mental) abilities, such as memory skills and concentration, and in brain anatomy (structure) and function, in people with lymphoma receiving CAR-T therapy.
- Trial name
- NCT04107285
- Testing
- neurocognitive evaluations, brain MRIs, Blood samples
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cognitive Change, Well-Being, Psychological
Trout Consumption in Young Children and Families and Brain Health
Regular fish consumption may support brain health. Trout lines developed in Idaho contain higher levels of omega-3 fatty acids, nutrients important for human cognition and mental wellbeing.
- Trial name
- NCT06721468
- Testing
- Trout, Child-centered nutrition phrases, Puzzle
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Idaho
Epilepsy, Seizures
Pharmacological Modulation of Brain Oscillations in Memory Processing
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity.
- Conditions
- Epilepsy, Seizures, Cognitive Impairment, Mild, Memory Disorders
- Trial name
- NCT05594017
- Testing
- Scopolamine (0.4mg)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Obesity and Overweight, Leptin Resistance
Reprogramming Energy Homeostasis in Overweight Individuals Via Exercise, Cognitive, and Social Training
The RESILIENT project is a clinical trial investigating leptin sensitivity in both children and adults with overweight or obesity.
- Conditions
- Obesity and Overweight, Leptin Resistance, Childhood Obesity
- Trial name
- Resilient (NCT06931730)
- Testing
- Nutritional Intervention, Physical Activity training, Cognitive training
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- Bambino Gesù Hospital and Research Institute