Clinical trials: Cognitive Change
Cognitive Change, Cytokine Levels
The Effect of Oral Use of Lyophilised Royal Jelly on Cognitive Functions and Immune System in Elderly Individuals
Dementia is a significant public health problem, affecting 47 million people worldwide in 2015, according to World Health Organization data. It is expected to increase to 75 million in 2030 and reach 132 million in 2050.
- Conditions
- Cognitive Change, Cytokine Levels, Neuroinflammation
- Trial name
- NCT06404203
- Testing
- Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 500 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1000 mg/day, Balparmak Apitera Royal Jelly Herbal Capsule Food Supplement 1500 mg/day
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Cognitive Change, Total Knee Anthroplasty
Early Cognitive Changes After General Versus Spinal Anesthesia in Older Adults Undergoing Total Knee Arthroplasty
This prospective observational study investigated early postoperative cognitive changes in older adults undergoing elective total knee arthroplasty under general or spinal anesthesia.
- Trial name
- NCT07860593
- Testing
- General Anesthesia, Spinal Anesthesia with Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Haseki Training and Research Hospital
Aging, Cognitive Change
Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging
Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly…
- Conditions
- Aging, Cognitive Change, Neurocognitive Disorders, Mild
- Trial name
- DecidingBrain (NCT05457725)
- Testing
- Contingent rtfMRI neurofeedback training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Florida
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Cognitive Performance, Inflammation
Peanut Consumption on Cognitive, Weight, and Inflammation
A multi-school, two-arm parallel cluster-randomized controlled trial will be conducted in 200 healthy young adolescents from Barcelona (Spain) to evaluate the effect of peanut consumption on cognitive performance, weight…
- Conditions
- Cognitive Performance, Inflammation, Weight Change, Body, Adolescents
- Trial name
- PEANUTY (NCT06127511)
- Testing
- Food (peanut)
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Breast Cancer, Chemotherapy Effect
Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy
The purpose of this research is to determine whether a 16-week high intensity interval training (HIIT) exercise program will improve brain health among women undergoing chemotherapy and also improve cardiovascular (heart)…
- Conditions
- Breast Cancer, Chemotherapy Effect, Exercise Therapy, Cognitive Change
- Trial name
- CLARITY (NCT04724499)
- Testing
- High-Intensity Intervals Training, Attention Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dana-Farber Cancer Institute
Ovarian Cancer, Cognitive Change
Cognitive Impact of Neoadjuvant Chemotherapy for Gynecologic Cancers
The purpose of this research is to assess several components of cognition in patients recently diagnosed with advanced epithelial ovarian cancer and who will be undergoing neoadjuvant chemotherapy for treatment of the cancer.
- Trial name
- NCT07125209
- Testing
- Patient Reported Outcomes Assessment, Cognitive and General Health Assessments
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Wisconsin, Madison
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Physical Inactivity, Aging
Motivating Activity Through Text Communications - Helping Adults Increase Movement
The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and…
- Conditions
- Physical Inactivity, Aging, Cognitive Ability, Behavior Change
- Trial name
- MATCH AIM (NCT07593677)
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep Disturbance, Cognitive Change
Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4
This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.
- Conditions
- Sleep Disturbance, Cognitive Change, Aging
- Trial name
- NCT07414680
- Where
- 2 sites in Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cognitive Impairment, Cognitive Change
Early Cognitive Interventions in Digital Format for Cancer Survivors
The aim of this study is to evaluate the usability and effectiveness of two professionally supervised home-based cognitive training interventions as part of an early rehabilitation protocol for cancer-related cognitive…
- Conditions
- Cognitive Impairment, Cognitive Change, Cancer
- Trial name
- INCOTEM (NCT07729969)
- Testing
- Computerized cognitive treatment, Virtual reality cognitive training
- Where
- 3 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Biogipuzkoa Health Research Institute
Cognitive Change, Achievement
Enhancing Children's Cognitive Function and Achievement Through Carotenoid Consumption
The aim of this study is to test the casual relationship between carotenoid supplementation, cognitive function, and achievement over a school-year.
- Conditions
- Cognitive Change, Achievement, Macular Pigmentation
- Trial name
- NCT05177679
- Testing
- Active supplement
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Aging, Aging Problems
Brain Health Virtual Reality Study
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa.
- Conditions
- Aging, Aging Problems, Memory Loss, Memory Impairment
- Trial name
- NCT06124339
- Testing
- Physical Activity, Cognitive Activity (VR), Physical and Cognitive Activity
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Mood, Cognitive Change
Investigating the Effects of Dietary Phospholipids on Measures of Human Brain Health and Psychological Wellbeing
The aim of this study is to investigate the effects of 6- and 12-week supplementation of a bioactive whey protein concentrate drink containing dairy phospholipids on cognitive function and mood in healthy young to middle aged…
- Conditions
- Mood, Cognitive Change, Well-Being, Psychological
- Trial name
- NCT06107075
- Testing
- Active
- Where
- United Kingdom
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Heat Stress, Physiological Stress
Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults
While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289/EHP11651), this guideline has not been verified in young, habitually active adults.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07267598
- Testing
- Simulated indoor temperature upper limit
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
SARS-CoV-2 Infection, Cognitive Change
The ACDC Study Assessing Cognitive Deterioration in COVID-19
The long-term impact and effects of COVID-19 are still being determined. However, what is clear, is that some people are still struggling following a period of illness with COVID-19.
- Conditions
- SARS-CoV-2 Infection, Cognitive Change, Cognitive Dysfunction
- Trial name
- ACDC (NCT05855434)
- Testing
- Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Grampian
Postprandial Glycemia, Metabolic Stress
WHNRC (Western Human Nutrition Research Center) Honey Study
The purpose of this research is to compare two snacks, one with honey and nuts and the other with sugar and nuts, on glucose levels before and after eating these snacks.
- Conditions
- Postprandial Glycemia, Metabolic Stress, Cognitive Change, Satisfaction, Personal
- Trial name
- NCT06107231
- Testing
- Honey, Sucrose, Honey plus almonds
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center