Clinical trials: Cognitive Changes
Overweight and Obesity
Weight Loss and Cognitive Function in Adults
More than two-thirds of middle-aged and older adults are overweight, which places them at greater risk of disability and higher medical expenses. Lifestyle interventions which promote weight loss for this population are needed.
- Trial name
- NCT03685305
- Testing
- Hypocaloric diet with hunger reduction strategy, Hypocaloric diet without hunger reduction strategy
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Cognitive Change
Validating the Digital Virginia Tech Carilion Cognitive Examination
Currently, cognitive screening is performed in-person after the individual expresses symptoms or it is noticed by someone close to them and are largely done in clinical settings.
- Trial name
- VTC-Cog (NCT04265898)
- Testing
- The Digital Virginia Tech Carilion Cognitive Examination
- Volunteers
- healthy volunteers welcome
- Sponsor
- Carilion Clinic
Cognitive Change
Cerebral Excitability and Cognitive Performance
This study investigates the perceptual and cognitive influences of low-intensity electrical brain stimulation (transcranial direct current stimulation; tDCS), versus control (sham) conditions.
- Trial name
- NCT03807934
- Testing
- Stimulation via Soterix Medical or Neuroelectrics noninvasive brain stimulation systems
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Tufts University
Oral Manifestations, Child Behavior
Change in Hygiene and Sugar Comsuption Habits After Use of Cognitive Behavioral Therapy in Pediatric Dentistry in Twins
The objective of this study is to verify the changing habits and their maintenance after using cognitive behavioral therapy, exploring factors that may be associated with these stages and the moment in which they occur.
- Conditions
- Oral Manifestations, Child Behavior, Adolescent Behavior, Change; Cognitive
- Trial name
- CARDEC-BC (NCT06961890)
- Testing
- Principals of cognitive behavioral therapy on guided changing hygiene and sugar comsuption habits
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cognitive Change, Sleep Deprivation
Sleep Deprivation Study
The purpose of this study is to evaluate the measures of brain function, both neurophysiological (event-related potentials (ERPs) and functional (cognitive assessments), in response to sleep deprivation.
- Conditions
- Cognitive Change, Sleep Deprivation, Caffeine
- Trial name
- NCT05560620
- Testing
- Sleep Deprivation, Caffeine, No Caffeine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NeuroCatch Inc.
Cognitive Ability, General, Dietary Modification
The Acute Effects Fortified Nutritional Supplementation on Childhood Cognition
The aim of this study is to investigate the acute effects of ingestion of carbohydrates - with different glycemic profiles - on cognitive function among preadolescent children (i.e., 9-10 years).
- Trial name
- NCT02630667
- Testing
- SLOW Carbohydrate, MEDIUM Carbohydrate, FAST Carbohydrate
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Dehydration, Cognitive Change
The Effects of Hydration on Gut Health and Thinking
The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool.
- Conditions
- Dehydration, Cognitive Change, Gastrointestinal Microbiota
- Trial name
- WatUP (NCT05315531)
- Testing
- Water Intake
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Behavioral
Cognitive Changes in Childs After Anesthesia / Surgery
The role of surgical stress and anesthesia is unknown in the early childhood. In vitro and animal studies showed a risk for treatment with anesthesia in the developmental brain.
- Trial name
- NCT02658526
- Testing
- anesthesia - surgery
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Konstanze Plaschke
Mild Cognitive Impairment, Cognitive Dysfunction
Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve
Normal ageing presents subtle cognitive changes that can be detected before meeting the criteria for Mild cognitive impairment (MCI).
- Trial name
- NCT06279325
- Testing
- Computerized cognitive stimulation program, Face-to-face training-explanatory session
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Cognitive Change, Creativity
Naturalistic Study of Microdosing With Psilocybin
This study seeks to understand the neural, cognitive and behavioral effects of low doses of psilocybin administered in the form of dried mushroom material (0.5 g of Psilocybe cubensis) consumed in natural settings following a…
- Conditions
- Cognitive Change, Creativity, Mood Change, Sleep
- Trial name
- NATMICRO (NCT05160220)
- Testing
- Psilocybin
- Where
- Argentina
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Memory Impairment
Cerebrovascular and Cognitive Improvement by Resveratrol (resVida) and Fruitflow-II (CCIRF-II)
The purpose of this study is to determine whether Fruitflow-II, Resveratrol (resVida), alone or in combination, are effective in the treatment of memory problems in adult patients with memory impairment.
- Trial name
- CCIRF-II (NCT01766180)
- Testing
- Fruitflow-II, resVida
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Neurolgy Institute for Brain Health and Fitness
Cognitive Change
Sharing History Through Active Reminiscence and Photo-imagery (SHARP) Pilot Program
SHARP is a neighborhood-based and technology-supported approach to brain health for older Black adults that integrates walking and image-prompted social reminiscence to maintain or improve brain health.
- Trial name
- SHARP (NCT05906654)
- Testing
- Sharing History through Active Reminiscence and Photo-imagery (SHARP)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Blood Glucose, Executive Function
MOReS Freestyle Libre Validation Study
To measure the effects of interrupting prolonged sitting with brief standing physical activity interventions on physical and cognitive performance, health and wellbeing in young people.
- Conditions
- Blood Glucose, Executive Function, Cognitive Change
- Trial name
- NCT04989712
- Testing
- Exposure
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Alzheimer Disease, Early Onset, MCI
The Interactive Physical and Cognitive Exercise System
This study is intended to clarify the benefits to brain health and thinking processes that result from different forms of exercise.
- Conditions
- Alzheimer Disease, Early Onset, MCI, Aging, Mild Cognitive Impairment
- Trial name
- iPACES™ (NCT03069391)
- Testing
- physical exercise alone (PES) first, cognitive exercise alone (iCE) first, interactive Physical and Cognitive Exercise (iPACES™)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Cognitive Change, Child Development
Conectar Jugando Online: Board Games to Improve Executive Function in School-age Children (CJ-Online)
Good development of executive functions at school has been related to a better adaptation of children in different areas of their daily life and, especially, with adequate academic performance.
- Trial name
- CJ-Online (NCT04823338)
- Testing
- Conectar Jugando Online Program
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Brain In Game scientific-technical service
Noise Exposure, Sleep Disturbance
Low Particle Emission and Low Noise Tyres
This study will investigate the biological mechanisms linking sleep disruption by noise and the development of disease. In a laboratory sleep study, the investigators will play synthesised automotive tyre sounds, investigating…
- Conditions
- Noise Exposure, Sleep Disturbance, Sleep Hygiene, Metabolic Disturbance
- Trial name
- LEON-T (NCT05611619)
- Testing
- Tyre noise - continuous flow, Tyre noise - discrete events, High noise level
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Cognitive Change
A Clinical Study on the Effect of DHA & ARA Candy on the Cognitive Improvement in Preschool Children
The goal of this interventional study is to evaluate the effectiveness of DHA (docosahexaenoic acid) \& ARA (arachidonic acid) Candy on the cognitive development of preschool children (2-6 years old).
- Trial name
- NCT06532435
- Testing
- DHA & ARA Candy
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong Sibote Biotechnology Co., Ltd.
Caregiver Distress
Internet-based Treatment for Informal Caregivers in Lithuania LINGI
The purpose of this study is to evaluate efficacy of internet intervention for informal caregivers in Lithuania in reducing their care-giving burden.
- Trial name
- LINGI (NCT04052724)
- Testing
- Intervention group LINGI
- Where
- Sweden
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Postoperative Neurocognitive Disorders
Validation of the Modified Cognitive Assessment Scale (MoCA Blind) for the Diagnosis of Postoperative Neurocognitive Disorders in Patients With Corneal Pathology in Russia.
Long-term observation has shown that patients with visual impairment often develop cognitive impairments. Due to the fact that patients who are planning to undergo corneal transplantation may have initial cognitive deficits…
- Trial name
- NCT07423416
- Testing
- Neurocognitive testing
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution