Clinical trials: Cognitive Changes
Engagement, Patient, Quality of Life
SimpleC Wellness Platform With Social Robot Interaction (Long-term)
This study will be conducted to test a Socially-Assistive Robot (SAR) system for residents in an Assisted Living environment. The goal of the SAR system is to enhance social engagement and connectedness.
- Conditions
- Engagement, Patient, Quality of Life, Mood, Aging Well
- Trial name
- NCT05599503
- Testing
- Behavioral Interventions, Robot Interventions
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- SimpleC, LLC
Inflammation, Inflammatory Response
Cannabis Observational Study on Mood, Inflammation, and Cognition
This project examines the effects of cannabis on cognition and other domains of function and whether those effects are dependent upon the ratio of THC to CBD in the product.
- Conditions
- Inflammation, Inflammatory Response, Mood, Cognitive Change
- Trial name
- COSMIC (NCT03522103)
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cognitive Change, Mood
Cognitive, Mood, Anti-Inflammatory and Metabolic Effects of Chronic Oyster Mushroom Intervention in Older Adults
The Pleurotus oyster species is a common edible mushroom rich in phytochemicals such as proteins, phenolic compounds, dietary fibre and is also particularly rich in ergothioneine, a bioactive known for its neurocognitive…
- Conditions
- Cognitive Change, Mood, Metabolism, Inflammatory Response
- Trial name
- OYSCOG (NCT06846827)
- Testing
- Oyster mushroom, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Reading
Sedentary Lifestyle, Worksite
Mid-term Effect of a Novel Sit-to-stand Workplace (ACTIVE OFFICE) on Cognitive and Physiological Parameters
Prolonged sitting is a risk factor for cardiovascular and musculoskeletal diseases, diabetes, several types of cancer and all-cause mortality.
- Trial name
- NCT02825303
- Testing
- Workplace consisting of two height-adjustable desks
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences Upper Austria
Frontotemporal Dementia, Behavioral Variant Frontotemporal Dementia
Cognitive, Behavioral, and Functional Change in Behavioral Variant Frontotemporal Dementia (bvFTD)
The objectives of the study are to; (1) estimate the change in disease -related cognitive decline over 1 year on a battery of cognitive tests administered to participants with early-stage symptomatic Behavioral Variant…
- Trial name
- FORWARD (NCT03088956)
- Testing
- Assessments
- Where
- 12 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Biogen
Alzheimer Disease
PET Changes in Alzheimer's Disease (AD)
The purpose of this study is to identify the earliest predictors of memory and brain deterioration in pre-clinical Alzheimer's disease using positron emission tomography (PET) to monitor brain glucose metabolism.
- Trial name
- NCT00094913
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Overweight and Obesity, Cancer
Devaluing Foods to Change Eating Behavior
Excessive eating of energy-dense foods and obesity are risk factors for a range of cancers. There are programs to reduce intake of these foods and weight loss, but the effects of the programs rarely last.
- Trial name
- NCT03557710
- Testing
- Devaluing energy-dense foods for cancer-control
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Healthy Volunteers, General Anaesthesia
Neuroplasticity Induced by General Anaesthesia
The aim of this study is to use magnetic resonance imaging to explore and compare possible de novo neuroplastic changes induced by the isolated effects of the hypnotic agents sevoflurane and propofol, respectively.
- Conditions
- Healthy Volunteers, General Anaesthesia, Neuroplasticity
- Trial name
- DANA1 (NCT04125121)
- Testing
- Sevoflurane-propofol
- Where
- 2 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Signe Sloth Madsen
Cognitive Change
Oral Contraceptive Consumption Timing and Cognition and Metabolism
The aim of this randomised-controlled trial is to examine whether the timing of oral contraceptive administration affects cognitive function, substrate metabolism and exercise performance.
- Trial name
- NCT06560944
- Testing
- Combined oral contraceptive pill
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Breast Cancer
Rehabilitation of Cognitive Changes in Breast Cancer Survivors
The purpose of this study is to test a memory training program for breast cancer survivors who have problems with memory after receiving chemotherapy.
- Trial name
- NCT01182506
- Testing
- Cogmed Working Memory Training Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cognitive Performance, Well-Being
TETRA (Terrestrial Trunked Radio)
The purpose of this study is to investigate if electromagnetic radiation from TETRA handset can influence cognitive function and the well-being of healthy adults.
- Trial name
- NCT00395668
- Testing
- TETRA (at lowest carrier freq, std TDMA pulse at 17,6 Hz).
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cognitive Impairment, Progressive, Cerebral Small Vessel Diseases
Circuit Training and Retina
The purpose of this research study is to see if high-speed weight training performed in a circuit (using one machine after another) can improve participant heart and brain function, strength, and power in older persons.
- Trial name
- NCT05714813
- Testing
- High-Speed Circuit Resistance Training, Lecture on Diet, Exercise and Cognition
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Overweight and Obesity, Cognitive Change
Acute Effects of Exercise Combined With Ketone Ester Supplement
To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults.
- Conditions
- Overweight and Obesity, Cognitive Change, Ketoses, Metabolic
- Trial name
- NCT06365957
- Testing
- Ketone monoester supplementation, High-intensity interval exercise, Moderate-intensity continuous exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Macau
Cognitive Change, Cognitive Decline
Normative Database and Test-Retest Reliability for BrainCheck Assessments
The purpose of this study is to collect normative test values and demographic information for normative and referential data for a rapid, portable, computerized neurocognitive testing device from healthy adults 50 and older.
- Conditions
- Cognitive Change, Cognitive Decline, Cognitive Deterioration, Neurocognitive Deficit
- Trial name
- NDTR (NCT05497427)
- Testing
- BrainCheck Assessment
- Where
- 5 sites in United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Cognitive Change
Assessing the Effects of the Muse Meditation System on Cognition and Well-being
Interaxon markets a head-worn EEG biofeedback device ('Muse') to encourage and aid effective meditation and sleep. This device has been previously shown to improve workplace wellness, fatigue and quality of life, and performance…
- Trial name
- MuseCog (NCT04790929)
- Testing
- Muse, Meditation Coaching
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Alcohol Drinking, Chronic Inflammation
30-to-90 Day Challenge: Effects of Alcohol Cessation on Health Outcomes
The objective for this project is to determine whether how certain behavioral and health functions change in persons with heavy drinking when they stop (or reduce) drinking for 30 days, and whether changes continue for up to 90…
- Conditions
- Alcohol Drinking, Chronic Inflammation, Neurocognitive Dysfunction, Liver Diseases
- Trial name
- NCT03353701
- Testing
- Contingency Management (CM)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mild Cognitive Impairment
Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
Individuals aged 55 and older may experience negative effects of cognitive decline. The proposed research seeks to evaluate the benefits of different types of interventions: reasoning training following transcranial direct…
- Trial name
- NCT02596906
- Testing
- tDCS
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Cognitively Normal, Mild Cognitive Impairment
Longitudinal Changes of [18F]PI-2620 Positron Emission Tomography in Subjects With Cognitively Normal, Mild Cognitive Impairment and Alzheimer's Disease
The overall goal of this imaging trial is to evaluate crosssectional difference and longitudinal changes of [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in cognitively normal individuals, and…
- Conditions
- Cognitively Normal, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03903211
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jae Seung Kim
Major Depression, Treatment
fMRI Study of Treatment Changes in Major Depression
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy…
- Trial name
- NCT01027559
- Testing
- Sertraline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Cardiovascular System, Respiratory System
Acute Health Effects of High Temperature Exposure
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.
- Conditions
- Cardiovascular System, Respiratory System, Cognitive Function
- Trial name
- NCT05575752
- Testing
- high temperature (32℃) group, moderate temperature (22℃) group
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fudan University